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> Protein (NX_Q13191)
Protein (NX_Q13191)
Protein
Gene SymbolCBLB to neXtProt (NX_Q13191)
DescriptionE3 ubiquitin-protein ligase CBL-B
Chromosome3
Location3q13.11 (105374305 ~ 105588396) to Ensembl
Sequene Features : Isoforms 3, Variants 148, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of T cell receptor signaling pathway
.negative regulation of alpha-beta T cell proliferation
.positive regulation of protein catabolic process
  + 7 more...
.ligase activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 148 14
2014-09-19protein level
3 115 14
2014-05-27protein level
3 115 14
2014-02-25protein level
3 115 14
2013-12-09protein level
4 100 13
2013-11-01protein level
4 96 13
2013-09-12protein level
4 96 13
2013-08-17protein level
4 96 13
2013-07-15protein level
4 55 10
2013-06-11protein level
4 55 10
2013-02-12protein level
4 32 31
2012-12-20protein level
4 35 31
2012-10-30protein level
4 39 31
2012-10-07protein level
4 39 11
2012-08-24protein level
4 24 11
2012-07-28protein level
4 24 11
2012-06-08protein level
4 39 11
2012-05-07protein level
4 39 11
2012-04-10protein level
4 39 11
2012-01-13protein level
4 45 11
2011-12-20protein level
4 45 11
2011-11-11protein level
4 45 10
2011-08-23protein level
4 45 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13191-1
8 38 3 109379.9651
NX_Q13191-2
1 38 3 90824.3837
NX_Q13191-3
0 37 3 86526.2714
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744027,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-744027,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
3 EBI-744027,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
4 EBI-744027,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
5 EBI-744027,EBI-910 CRKL  
  .parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
6 EBI-744027,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
7 EBI-744027,EBI-1380492 UBASH3B  
  .negative regulation of platelet aggregation
.regulation of release of sequestered calcium ion into cytosol
.negative regulation of protein kinase activity
.protein tyrosine phosphatase activity .cytoplasm
.nucleus
8 EBI-744027,EBI-346595 SH3KBP1  
  .negative regulation of epidermal growth factor receptor signaling pathway
.cell migration
.regulation of cell shape
  + 5 more...
.N/A .synapse
.neuron projection
.cytoplasmic vesicle membrane
  + 5 more...
9 EBI-744027,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
10 EBI-744027,EBI-346622 ASAP1  
  .cilium morphogenesis
.organelle organization
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.GTPase activator activity
.membrane
.cytosol
11 EBI-744027,EBI-298152 CD2AP  
  .regulation of actin cytoskeleton reorganization
.positive regulation of protein localization to nucleus
.cell division
  + 5 more...
.SH3 domain binding
.structural constituent of cytoskeleton
.extracellular exosome
.filamentous actin
.actin cytoskeleton
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood24
bone27
bone marrow41
brain42
connective tissue53
embryonic tissue56
eye71
heart67
intestine34
kidney42
larynx42
liver24
lung35
lymph90
lymph node77
mammary gland26
mouth211
muscle28
nerve64
ovary19
pancreas65
pharynx24
placenta81
prostate31
skin18
stomach10
testis64
trachea173
uterus34
vascular19
Health State
TissuesTPM*
normal51
breast (mammary gland) tumor10
chondrosarcoma36
colorectal tumor35
gastrointestinal tumor8
germ cell tumor30
glioma27
head and neck tumor112
kidney tumor29
lung tumor48
lymphoma83
non-neoplasia72
ovarian tumor26
pancreatic tumor57
primitive neuroectodermal tumor of the CNS39
prostate cancer9
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor7
uterine tumor55
Developmental Stage
TissuesTPM*
adult37
embryoid body57
blastocyst48
neonate32
fetus78
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.8
adrenal gland12.5
appendix16.7
bone marrow11.5
cerebral cortex3.9
colon10.8
duodenum11.9
esophagus7
gallbladder16.6
heart muscle11.4
kidney7.3
liver5.6
lung10.6
lymph node26.3
ovary15.6
pancreas3.8
placenta18.1
prostate8
salivary gland7.2
skin4.8
small intestine11
spleen14.1
stomach17.1
testis15.5
thyroid gland15
urinary bladder14.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604491, gene) Cas-br-m murine ecotropic retroviral transforming sequence b; CBLBOMIM
2acute myelogenous leukemiaCGP


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