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> Protein (NX_Q13227)
Protein (NX_Q13227)
Protein
Gene SymbolGPS2 to neXtProt (NX_Q13227)
DescriptionG protein pathway suppressor 2
Chromosome17
Location17p13.1 (7214643 ~ 7218883) to Ensembl
Sequene Features : Isoforms 2, Variants 21, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of JNK cascade
.negative regulation of GTPase activity
.JNK cascade
  + 4 more...
.GTPase inhibitor activity
.transcription corepressor activity
.transcriptional repressor complex
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 21 4
2014-09-19protein level
1 19 4
2014-05-27protein level
1 19 4
2014-02-25protein level
1 19 1
2013-12-09protein level
1 14 1
2013-11-01protein level
1 14 1
2013-09-12protein level
1 14 1
2013-08-17protein level
1 14 1
2013-07-15protein level
1 14 1
2013-06-11protein level
1 14 1
2013-02-12protein level
1 3 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 4 0
2012-10-07protein level
1 4 0
2012-08-24protein level
1 3 0
2012-07-28protein level
1 3 0
2012-06-08protein level
1 3 0
2012-05-07protein level
1 2 0
2012-04-10protein level
1 2 0
2012-01-13protein level
1 7 0
2011-12-20protein level
1 7 0
2011-11-11protein level
1 7 0
2011-08-23protein level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13227-1
2 9 0 36665.4005
NX_Q13227-2
0 9 0 33885.0037
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-713355,EBI-492498 ATF4  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of oxidative stress-induced neuron death
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  + 21 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 9 more...
.CHOP-ATF4 complex
.ATF1-ATF4 transcription factor complex
.ATF4-CREB1 transcription factor complex
  + 8 more...
2 EBI-713355,EBI-748831 MAP3K7CL  
  .N/A .N/A .cytosol
.nucleus
3 EBI-713355,EBI-749285 RALBP1  
  .regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
.regulation of GTPase activity
  + 5 more...
.Rac GTPase binding
.ATPase activity, coupled to movement of substances
.Ral GTPase binding
  + 2 more...
.membrane
.cytosol
4 EBI-713355,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
5 EBI-713355,EBI-6117072 SESTD1  
  .N/A .phosphatidylinositol-3,5-bisphosphate binding
.phosphatidic acid binding
.phosphatidylinositol-4-phosphate binding
  + 4 more...
.N/A
6 EBI-713355,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
7 EBI-713355,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood40
bone69
bone marrow82
brain50
cervix61
connective tissue26
embryonic tissue70
eye62
heart11
intestine47
kidney18
larynx42
liver43
lung41
lymph158
lymph node22
mammary gland33
muscle9
nerve64
ovary59
pancreas84
pharynx24
pituitary gland60
placenta52
prostate36
salivary gland98
skin156
spleen18
stomach94
testis94
thymus50
thyroid150
tonsil117
uterus77
vascular19
Health State
TissuesTPM*
normal44
adrenal tumor79
breast (mammary gland) tumor53
cervical tumor86
chondrosarcoma60
colorectal tumor35
gastrointestinal tumor67
germ cell tumor45
glioma37
head and neck tumor59
kidney tumor43
leukemia42
liver tumor62
lung tumor29
lymphoma110
non-neoplasia20
ovarian tumor52
pancreatic tumor85
primitive neuroectodermal tumor of the CNS110
prostate cancer38
retinoblastoma107
skin tumor255
soft tissue/muscle tissue tumor87
uterine tumor66
Developmental Stage
TissuesTPM*
adult46
embryoid body100
blastocyst48
fetus35
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.4
adrenal gland42.6
appendix41.4
bone marrow43.1
cerebral cortex28.1
colon37.9
duodenum34.2
esophagus32.9
gallbladder32.4
heart muscle33.9
kidney38.1
liver18.7
lung37.8
lymph node46.1
ovary37.8
pancreas19.4
placenta34.1
prostate32.4
salivary gland33.6
skin39.7
small intestine32.1
spleen43.3
stomach30.9
testis75.9
thyroid gland37.4
urinary bladder33.2
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*601935, gene) G protein pathway suppressor 2; GPS2OMIM


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