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> Protein (NX_Q13233)
Protein (NX_Q13233)
Protein
Gene SymbolMAP3K1 to neXtProt (NX_Q13233)
DescriptionMitogen-activated protein kinase kinase kinase 1
Chromosome5
Location5q11.2 (56111401 ~ 56191979) to Ensembl
Sequene Features : Isoforms 1, Variants 167, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to mechanical stimulus
.eyelid development in camera-type eye
.stress-activated MAPK cascade
  + 21 more...
.protein kinase binding
.JUN kinase kinase activity
.zinc ion binding
  + 3 more...
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 167 16
2014-09-19protein level
1 131 16
2014-05-27protein level
1 131 16
2014-02-25protein level
1 131 16
2013-12-09protein level
1 97 16
2013-11-01protein level
1 94 16
2013-09-12protein level
1 94 16
2013-08-17protein level
1 94 16
2013-07-15protein level
1 39 14
2013-06-11protein level
1 39 14
2013-02-12protein level
1 19 25
2012-12-20protein level
1 21 25
2012-10-30protein level
1 35 25
2012-10-07protein level
1 35 25
2012-08-24protein level
1 33 25
2012-07-28protein level
1 30 25
2012-06-08protein level
1 45 25
2012-05-07protein level
1 36 25
2012-04-10protein level
1 36 25
2012-01-13protein level
1 37 25
2011-12-20protein level
1 37 25
2011-11-11protein level
1 37 25
2011-08-23protein level
1 33 25
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13233-1
65 0 0 164365.8655
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-49776,EBI-352089 FLNB  
  .cell differentiation
.actin cytoskeleton organization
.cytokine-mediated signaling pathway
  + 3 more...
.poly(A) RNA binding
.identical protein binding
.actin binding
.extracellular exosome
.Z disc
.integral component of membrane
  + 7 more...
2 EBI-49776,EBI-365980 BRAF  
  .negative regulation of endothelial cell apoptotic process
.negative regulation of synaptic vesicle exocytosis
.positive regulation of substrate adhesion-dependent cell spreading
  + 28 more...
.identical protein binding
.ATP binding
.calcium ion binding
  + 3 more...
.cell body
.neuron projection
.plasma membrane
  + 3 more...
3 EBI-49776,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
4 EBI-49776,EBI-447868 MAP2K4  
  .cellular response to sorbitol
.cellular response to mechanical stimulus
.cell growth involved in cardiac muscle cell development
  + 22 more...
.JUN kinase kinase activity
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.perikaryon
.dendrite cytoplasm
.axon
  + 3 more...
5 EBI-49776,EBI-359808 DCAF7  
  .protein ubiquitination
.multicellular organismal development
.N/A .Cul4-RING E3 ubiquitin ligase complex
.protein complex
.nuclear matrix
  + 2 more...
6 EBI-49776,EBI-49783 MAP4K2  
  .positive regulation of JNK cascade
.innate immune response
.regulation of apoptotic process
  + 8 more...
.mitogen-activated protein kinase kinase kinase binding
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.basolateral plasma membrane
.Golgi membrane
7 EBI-49776,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
bone13
bone marrow41
brain7
cervix20
connective tissue20
ear62
embryonic tissue9
eye14
heart11
intestine12
kidney37
liver14
lung8
lymph node122
mammary gland46
mouth30
muscle18
ovary68
pancreas4
pharynx24
placenta24
prostate26
skin28
spleen18
testis16
thyroid107
trachea19
uterus12
vascular19
Health State
TissuesTPM*
normal18
breast (mammary gland) tumor21
chondrosarcoma36
gastrointestinal tumor8
germ cell tumor22
glioma9
head and neck tumor59
kidney tumor14
leukemia31
liver tumor10
non-neoplasia10
ovarian tumor91
prostate cancer9
skin tumor39
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult25
embryoid body14
blastocyst16
fetus17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.8
adrenal gland5.8
appendix16.7
bone marrow17.9
cerebral cortex2.7
colon6.5
duodenum7
esophagus11.3
gallbladder7.7
heart muscle3
kidney10.4
liver4.6
lung8
lymph node23.5
ovary7.6
pancreas4.7
placenta10.3
prostate6.4
salivary gland16.8
skin25.2
small intestine7.1
spleen22.9
stomach8.7
testis10
thyroid gland16.2
urinary bladder10.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleHigh
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverHigh
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaLow
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600982, gene) Mitogen-activated kinase kinase kinase 1; MAP3K1OMIM
2(#613762, phenotype) 46,xy sex reversal 6; SRXY6OMIM


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