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> Protein (NX_Q13277)
Protein (NX_Q13277)
Protein
Gene SymbolSTX3 to neXtProt (NX_Q13277)
DescriptionSyntaxin-3
Chromosome11
Location11q12.1 (59480929 ~ 59573354) to Ensembl
Sequene Features : Isoforms 3, Variants 44, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein localization to cell surface
.positive regulation of protein localization to plasma membrane
.long-term synaptic potentiation
  + 7 more...
.arachidonic acid binding
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.neuron projection
.azurophil granule
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 44 0
2014-09-19protein level
3 40 0
2014-05-27protein level
3 40 0
2014-02-25protein level
3 40 0
2013-12-09protein level
3 33 0
2013-11-01protein level
3 31 0
2013-09-12protein level
3 31 0
2013-08-17protein level
3 31 0
2013-07-15protein level
3 17 0
2013-06-11protein level
3 17 0
2013-02-12protein level
3 15 0
2012-12-20protein level
3 15 0
2012-10-30protein level
3 16 0
2012-10-07protein level
3 16 0
2012-08-24protein level
3 16 0
2012-07-28protein level
3 16 0
2012-06-08protein level
3 21 0
2012-05-07protein level
3 15 0
2012-04-10protein level
2 15 0
2012-01-13protein level
2 9 0
2011-12-20protein level
2 9 0
2011-11-11protein level
2 9 0
2011-08-23protein level
2 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13277-1
0 11 0 33134.3223
NX_Q13277-2
1 10 0 28842.1554
NX_Q13277-3
1 10 0 31998.4337
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1394295,EBI-296817 ZFYVE9  
  .negative regulation of transforming growth factor beta receptor signaling pathway
.SMAD protein import into nucleus
.SMAD protein complex assembly
  + 3 more...
.metal ion binding
.serine-type peptidase activity
.1-phosphatidylinositol binding
.early endosome membrane
.early endosome
2 EBI-1394295,EBI-744942 STX4  
  .positive regulation of protein localization to cell surface
.positive regulation of protein localization to plasma membrane
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 21 more...
.sphingomyelin phosphodiesterase activator activity
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.perinuclear region of cytoplasm
.synapse
  + 19 more...
3 EBI-1394295,EBI-3921185 NAPB  
  .membrane fusion
.SNARE complex disassembly
.intracellular protein transport
.syntaxin binding
.soluble NSF attachment protein activity
.extracellular exosome
.SNARE complex
.vacuolar membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites75
bladder66
blood65
bone55
brain30
cervix41
connective tissue20
embryonic tissue65
eye124
heart67
intestine116
kidney123
larynx42
liver24
lung92
mammary gland105
mouth45
muscle28
nerve64
ovary29
pancreas79
parathyroid291
pharynx98
placenta102
prostate36
skin151
stomach188
testis68
thymus12
thyroid42
trachea38
uterus38
vascular77
Health State
TissuesTPM*
normal60
bladder carcinoma170
breast (mammary gland) tumor96
cervical tumor28
chondrosarcoma72
colorectal tumor124
gastrointestinal tumor118
germ cell tumor83
head and neck tumor74
kidney tumor72
leukemia10
liver tumor20
lung tumor107
non-neoplasia82
ovarian tumor39
pancreatic tumor85
prostate cancer28
retinoblastoma150
skin tumor159
soft tissue/muscle tissue tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult81
embryoid body85
blastocyst81
neonate32
fetus61
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.4
adrenal gland19.4
appendix18.5
bone marrow52.1
cerebral cortex7.4
colon39.2
duodenum37.2
esophagus13.6
gallbladder28.8
heart muscle8.5
kidney39.9
liver8.3
lung31.1
lymph node6.7
ovary11.8
pancreas8.6
placenta36.7
prostate14.3
salivary gland8.4
skin9.1
small intestine28.3
spleen11.1
stomach36.2
testis18.2
thyroid gland17.9
urinary bladder18.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600876, gene) Syntaxin 3; STX3OMIM


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