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> Protein (NX_Q13287)
Protein (NX_Q13287)
Protein
Gene SymbolNMI to neXtProt (NX_Q13287)
DescriptionN-myc-interactor
Chromosome2
Location2q23.3 (152126979 ~ 152146571) to Ensembl
Sequene Features : Isoforms 1, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of nucleic acid-templated transcription
.JAK-STAT cascade
.inflammatory response
.transcription from RNA polymerase II promoter
.transcription cofactor activity .cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 38 9
2014-09-19protein level
1 32 9
2014-05-27protein level
1 32 9
2014-02-25protein level
1 31 9
2013-12-09protein level
1 17 9
2013-11-01protein level
1 17 9
2013-09-12protein level
1 17 9
2013-08-17protein level
1 17 9
2013-07-15protein level
1 12 0
2013-06-11protein level
1 12 0
2013-02-12protein level
1 9 0
2012-12-20protein level
1 10 0
2012-10-30protein level
1 13 0
2012-10-07protein level
1 13 0
2012-08-24protein level
1 10 0
2012-07-28protein level
1 10 0
2012-06-08protein level
1 11 0
2012-05-07protein level
1 11 0
2012-04-10protein level
1 11 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13287-1
18 0 0 35034.8443
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-372942,EBI-523498 TRAF5  
  .positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 4 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
  + 2 more...
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
2 EBI-372942,EBI-749483 SNAPC5  
  .gene expression
.transcription initiation from RNA polymerase III promoter
.transcription from RNA polymerase III promoter
.transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity .nucleolus
.nucleoplasm
.nucleus
3 EBI-372942,EBI-7543896 SCEL  
  .keratinocyte differentiation
.embryo development
.epidermis development
.zinc ion binding .extracellular exosome
.cytoplasm
.cornified envelope
4 EBI-372942,EBI-8473670 LCA5L  
  .N/A .N/A .N/A
5 EBI-372942,EBI-878369 MYCN  
  .negative regulation of reactive oxygen species metabolic process
.branching morphogenesis of an epithelial tube
.negative regulation of astrocyte differentiation
  + 8 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
.chromatin
6 EBI-372942,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
7 EBI-372942,EBI-1186119 STAT5B  
  .cellular response to epidermal growth factor stimulus
.cellular response to growth factor stimulus
.response to interleukin-15
  + 54 more...
.protein dimerization activity
.glucocorticoid receptor binding
.signal transducer activity
  + 4 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
8 EBI-372942,EBI-1167533 SOX10  
  .negative regulation of canonical Wnt signaling pathway
.oligodendrocyte differentiation
.developmental growth
  + 13 more...
.identical protein binding
.transcription coactivator activity
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 4 more...
.extrinsic component of mitochondrial outer membrane
.nucleus
9 EBI-372942,EBI-10181276 GOLGA8DP  
  .N/A .N/A .Golgi apparatus
10 EBI-372942,EBI-355068 TUBA3D  
  .protein polymerization
.'de novo' posttranslational protein folding
.cellular protein metabolic process
  + 2 more...
.GTP binding
.structural constituent of cytoskeleton
.GTPase activity
.microtubule
.cytoplasm
.nucleus
11 EBI-372942,EBI-712181 MAD2L1BP  
  .regulation of exit from mitosis
.mitotic cell cycle checkpoint
.N/A .intracellular membrane-bounded organelle
.spindle
.cytoplasm
  + 2 more...
12 EBI-372942,EBI-10253274 CNKSR3  
  .negative regulation of ERK1 and ERK2 cascade
.negative regulation of peptidyl-serine phosphorylation
.positive regulation of sodium ion transport
.N/A .membrane
.cytoplasm
13 EBI-372942,EBI-2551023 TUBA3E  
  .protein polymerization
.microtubule-based process
.GTP binding
.structural constituent of cytoskeleton
.GTPase activity
.microtubule
.cytoplasm
.nucleus
14 EBI-372942,EBI-1104535 SFR1  
  .double-strand break repair via homologous recombination .N/A .Swi5-Sfr1 complex
.nucleus
15 EBI-372942,EBI-750003 HDDC3  
  .N/A .metal ion binding
.guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
.N/A
16 EBI-372942,EBI-747505 C1orf216  
  .N/A .N/A .N/A
17 EBI-372942,EBI-2961725 C9orf72  
  .autophagy
.endocytosis
.Rab GTPase binding .intercellular bridge
.cytoplasmic vesicle
.actin cytoskeleton
  + 7 more...
18 EBI-372942,EBI-744593 MTMR9  
  .N/A .enzyme regulator activity .cytoplasm
19 EBI-372942,EBI-2510162 COPS7B  
  .cullin deneddylation .N/A .COP9 signalosome
.cytoplasm
.nucleoplasm
20 EBI-372942,EBI-714781 BRMS1  
  .positive regulation of anoikis
.positive regulation of protein deacetylation
.negative regulation of transcription, DNA-templated
  + 6 more...
.NF-kappaB binding
.histone deacetylase binding
.Sin3-type complex
.cytoplasm
.nucleoplasm
.nucleus
21 EBI-372942,EBI-750554 HHLA3  
  .N/A .N/A .N/A
22 EBI-372942,EBI-766064 MTMR6  
  .potassium ion transmembrane transport
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
  + 4 more...
.phosphatidylinositol phosphate phosphatase activity
.calcium-activated potassium channel activity
.protein tyrosine phosphatase activity
.protein serine/threonine phosphatase activity
.cytosol
.cytoplasm
.nuclear envelope
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder100
blood40
bone83
bone marrow61
brain6
cervix61
connective tissue26
ear124
eye9
intestine21
kidney61
liver19
lung44
lymph node100
mammary gland6
muscle9
ovary59
pancreas32
pharynx24
placenta60
prostate15
salivary gland148
skin23
spleen37
stomach41
testis4
thymus25
umbilical cord145
uterus43
vascular19
Health State
TissuesTPM*
normal23
bladder carcinoma56
cervical tumor57
chondrosarcoma60
colorectal tumor17
gastrointestinal tumor25
germ cell tumor49
glioma18
kidney tumor43
leukemia31
liver tumor10
lung tumor19
lymphoma27
non-neoplasia31
ovarian tumor52
pancreatic tumor19
primitive neuroectodermal tumor of the CNS15
skin tumor23
soft tissue/muscle tissue tumor79
uterine tumor55
Developmental Stage
TissuesTPM*
adult28
neonate64
fetus12
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.7
adrenal gland10.8
appendix33.2
bone marrow29.2
cerebral cortex3.7
colon17.6
duodenum21.7
esophagus13.5
gallbladder18.1
heart muscle4.3
kidney8.7
liver10.6
lung17.2
lymph node29.4
ovary11
pancreas2.5
placenta22.1
prostate9.6
salivary gland10.4
skin10.6
small intestine22.6
spleen28.9
stomach17.5
testis5.9
thyroid gland11.8
urinary bladder21.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603525, gene) Nmyc interactor; NMIOMIM


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2014-2019 (C) Yonsei Proteome Research Center