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> Protein (NX_Q13309)
Protein (NX_Q13309)
Protein
Gene SymbolSKP2 to neXtProt (NX_Q13309)
DescriptionS-phase kinase-associated protein 2
Chromosome5
Location5p13.2 (36152091 ~ 36184421) to Ensembl
Sequene Features : Isoforms 3, Variants 52, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to cell-matrix adhesion
.regulation of cell cycle
.positive regulation of smooth muscle cell proliferation
  + 8 more...
.identical protein binding
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.aggresome
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 52 8
2014-09-19protein level
3 39 8
2014-05-27protein level
3 38 8
2014-02-25protein level
3 38 8
2013-12-09protein level
3 30 8
2013-11-01protein level
3 29 8
2013-09-12protein level
3 29 8
2013-08-17protein level
3 29 8
2013-07-15protein level
3 21 5
2013-06-11protein level
3 21 5
2013-02-12protein level
3 6 8
2012-12-20protein level
2 7 8
2012-10-30protein level
2 7 4
2012-10-07protein level
2 7 2
2012-08-24protein level
2 6 2
2012-07-28protein level
2 6 2
2012-06-08protein level
2 17 2
2012-05-07protein level
2 14 2
2012-04-10protein level
2 14 2
2012-01-13protein level
2 14 2
2011-12-20protein level
2 14 2
2011-11-11protein level
2 14 2
2011-08-23protein level
2 14 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13309-1
0 22 0 47730.4509
NX_Q13309-2
3 17 0 46545.7252
NX_Q13309-4
1 11 0 23748.1575
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-456291,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
2 EBI-456291,EBI-975493 DUSP1  
  .negative regulation of DNA biosynthetic process
.regulation of mitotic cell cycle spindle assembly checkpoint
.mitotic cell cycle arrest
  + 23 more...
.MAP kinase tyrosine/serine/threonine phosphatase activity
.protein tyrosine/threonine phosphatase activity
.protein tyrosine/serine/threonine phosphatase activity
.non-membrane spanning protein tyrosine phosphatase activity
.cytoplasm
.nucleus
3 EBI-7791408,EBI-354213 PHB  
  .negative regulation of glucocorticoid receptor signaling pathway
.positive regulation of protein stabilization
.DNA biosynthetic process
  + 20 more...
.transcription regulatory region DNA binding
.histone deacetylase binding
.proteinase activated receptor binding
  + 4 more...
.extracellular exosome
.membrane
.cell surface
  + 8 more...
4 EBI-456291,EBI-375077 CDKN1A  
  .positive regulation of reactive oxygen species metabolic process
.regulation of DNA biosynthetic process
.negative regulation of G1/S transition of mitotic cell cycle
  + 44 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin-dependent protein kinase activating kinase activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.PCNA-p21 complex
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 4 more...
5 EBI-456291,EBI-519280 CDKN1B  
  .mitotic cell cycle arrest
.cellular response to organic cyclic compound
.cellular response to lithium ion
  + 39 more...
.protein phosphatase binding
.transforming growth factor beta receptor, cytoplasmic mediator activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.Cul4A-RING E3 ubiquitin ligase complex
.cytosol
.endosome
  + 3 more...
6 EBI-456291,EBI-456371 CKS1B  
  .cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
7 EBI-456291,EBI-398523 RBX1  
  .negative regulation of canonical Wnt signaling pathway
.cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 11 more...
.cullin family protein binding
.ubiquitin protein ligase activity
.ubiquitin-ubiquitin ligase activity
  + 4 more...
.nuclear SCF ubiquitin ligase complex
.Cul7-RING ubiquitin ligase complex
.Cul5-RING ubiquitin ligase complex
  + 9 more...
8 EBI-456291,EBI-307486 SKP1  
  .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
.innate immune response
  + 11 more...
.ubiquitin-protein transferase activity .extracellular exosome
.Cul7-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
9 EBI-456291,EBI-447295 EP300  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.regulation of tubulin deacetylation
  + 40 more...
.pre-mRNA intronic binding
.androgen receptor binding
.nuclear hormone receptor binding
  + 17 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
  + 2 more...
10 EBI-456291,EBI-374847 ORC1  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
  + 2 more...
.ATP binding
.chromatin binding
.DNA binding
.plasma membrane
.cytosol
.cytoplasm
  + 5 more...
11 EBI-456291,EBI-359390 CUL1  
  .intrinsic apoptotic signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 17 more...
.N/A .Parkin-FBXW7-Cul1 ubiquitin ligase complex
.cullin-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
12 EBI-456291,EBI-724621 SIRT3  
  .peptidyl-lysine deacetylation
.aerobic respiration
.aging
  + 4 more...
.NAD+ binding
.NAD-dependent histone deacetylase activity (H3-K14 specific)
.zinc ion binding
.NAD+ ADP-ribosyltransferase activity
.membrane
.mitochondrial matrix
.mitochondrion
13 EBI-456291,EBI-724997 FZR1  
  .negative regulation of cell aging
.protein K11-linked ubiquitination
.lens fiber cell differentiation
  + 13 more...
.N/A .nuclear membrane
.cytosol
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder133
bone83
bone marrow20
brain28
cervix41
connective tissue13
embryonic tissue84
eye28
heart33
intestine25
kidney61
liver29
lung20
lymph node44
mammary gland19
mouth90
muscle84
ovary49
pancreas42
placenta155
prostate21
skin14
stomach31
testis13
thymus50
trachea57
uterus38
Health State
TissuesTPM*
normal34
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma48
colorectal tumor8
gastrointestinal tumor16
germ cell tumor125
head and neck tumor44
kidney tumor116
leukemia21
liver tumor31
lung tumor29
lymphoma55
non-neoplasia10
ovarian tumor65
pancreatic tumor76
primitive neuroectodermal tumor of the CNS39
prostate cancer9
retinoblastoma64
skin tumor23
soft tissue/muscle tissue tumor103
uterine tumor22
Developmental Stage
TissuesTPM*
adult39
embryoid body85
blastocyst97
fetus37
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.4
adrenal gland6
appendix7.9
bone marrow10.2
cerebral cortex4.1
colon8.4
duodenum9.8
esophagus9
gallbladder3.9
heart muscle2.2
kidney3.1
liver5.9
lung5.6
lymph node10.8
ovary6.9
pancreas1.9
placenta53.9
prostate4.6
salivary gland3.6
skin6.8
small intestine8
spleen7.1
stomach4.8
testis4.5
thyroid gland4.1
urinary bladder8.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601436, gene) S-phase kinase-associated protein 2; SKP2OMIM


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