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> Protein (NX_Q13315)
Protein (NX_Q13315)
Protein
Gene SymbolATM to neXtProt (NX_Q13315)
DescriptionSerine-protein kinase ATM
Chromosome11
Location11q22.3 (108093211 ~ 108239829) to Ensembl
Sequene Features : Isoforms 1, Variants 750, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cellular response to heat
.replicative senescence
.signal transduction involved in mitotic G2 DNA damage checkpoint
  + 33 more...
.protein N-terminus binding
.protein dimerization activity
.histone serine kinase activity
  + 6 more...
.cytoplasmic membrane-bounded vesicle
.spindle
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 750 20
2014-09-19protein level
1 664 20
2014-05-27protein level
1 664 21
2014-02-25protein level
1 661 20
2013-12-09protein level
1 603 20
2013-11-01protein level
1 590 18
2013-09-12protein level
1 590 18
2013-08-17protein level
1 590 18
2013-07-15protein level
1 393 8
2013-06-11protein level
1 393 8
2013-02-12protein level
1 285 12
2012-12-20protein level
1 286 12
2012-10-30protein level
1 298 12
2012-10-07protein level
1 298 12
2012-08-24protein level
1 293 12
2012-07-28protein level
1 293 12
2012-06-08protein level
1 224 12
2012-05-07protein level
1 224 12
2012-04-10protein level
1 224 12
2012-01-13protein level
1 220 12
2011-12-20protein level
1 220 12
2011-11-11protein level
1 220 12
2011-08-23protein level
1 220 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13315-1
142 0 0 350461.0758
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-495465,EBI-1055680 TTI1  
  .regulation of TOR signaling .N/A .TORC2 complex
.TORC1 complex
.cytoplasm
2 EBI-495465,EBI-7422202 ATMIN  
  .positive regulation of transcription, DNA-templated
.cellular response to DNA damage stimulus
.transcription, DNA-templated
.metal ion binding
.dynein binding
.transcription regulatory region DNA binding
.nucleus
3 EBI-495465,EBI-9057228 NAT2  
  .small molecule metabolic process
.xenobiotic metabolic process
.arylamine N-acetyltransferase activity .cytosol
4 EBI-495465,EBI-710997 TERF1  
  .negative regulation of telomerase activity
.cell division
.protein homooligomerization
  + 14 more...
.protein heterodimerization activity
.protein homodimerization activity
.telomeric DNA binding
  + 5 more...
.spindle
.cytoplasm
.nucleolus
  + 5 more...
5 EBI-495465,EBI-3915542 IL24  
  .cellular response to interleukin-4
.cellular response to lipopolysaccharide
.positive regulation of JAK-STAT cascade
  + 11 more...
.cytokine activity .endoplasmic reticulum
.extracellular space
6 EBI-495465,EBI-495644 MDC1  
  .cellular protein metabolic process
.post-translational protein modification
.intra-S DNA damage checkpoint
  + 4 more...
.FHA domain binding
.protein C-terminus binding
.focal adhesion
.chromosome
.nucleoplasm
.nucleus
7 EBI-495465,EBI-2120336 NABP2  
  .response to ionizing radiation
.mitotic cell cycle checkpoint
.cellular response to DNA damage stimulus
  + 2 more...
.single-stranded DNA binding .SOSS complex
.cytoplasm
.nucleoplasm
.nucleus
8 EBI-495465,EBI-3390132 WHSC1L1  
  .negative regulation of transcription, DNA-templated
.histone methylation
.transcription, DNA-templated
.chromatin organization
.histone methyltransferase activity (H3-K27 specific)
.histone methyltransferase activity (H3-K4 specific)
.histone-lysine N-methyltransferase activity
.zinc ion binding
.chromosome
.nucleoplasm
.nucleus
9 EBI-495465,EBI-372428 AATF  
  .negative regulation of reactive oxygen species metabolic process
.apoptotic signaling pathway
.neurotrophin TRK receptor signaling pathway
  + 10 more...
.poly(A) RNA binding
.leucine zipper domain binding
.sequence-specific DNA binding transcription factor activity
.focal adhesion
.centrosome
.Golgi apparatus
  + 3 more...
10 EBI-495465,EBI-1043674 TELO2  
  .regulation of TOR signaling .protein complex binding .TORC2 complex
.TORC1 complex
.membrane
  + 4 more...
11 EBI-495465,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
bladder33
blood32
bone marrow20
brain34
connective tissue13
embryonic tissue46
esophagus49
eye71
heart11
intestine64
kidney23
liver34
lung41
lymph node256
mammary gland132
mouth45
muscle94
nerve128
pancreas9
parathyroid97
pharynx147
placenta42
prostate31
skin9
spleen37
stomach20
testis25
thymus50
thyroid21
trachea19
uterus60
vascular58
Health State
TissuesTPM*
normal53
adrenal tumor158
breast (mammary gland) tumor85
colorectal tumor79
esophageal tumor57
gastrointestinal tumor16
germ cell tumor15
head and neck tumor22
leukemia31
liver tumor10
lung tumor9
lymphoma41
non-neoplasia82
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer28
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor44
Developmental Stage
TissuesTPM*
adult56
embryoid body42
blastocyst65
fetus41
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12
adrenal gland16
appendix36.4
bone marrow19.1
cerebral cortex13.3
colon13.6
duodenum6.3
esophagus8.9
gallbladder17
heart muscle9.7
kidney12.7
liver9.2
lung14.3
lymph node66
ovary31
pancreas10.8
placenta11.9
prostate11.7
salivary gland18.1
skin12.9
small intestine9.8
spleen39.4
stomach17.1
testis11.8
thyroid gland18.3
urinary bladder18.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleLow
liverMedium
lungHigh
lymph nodeHigh
oral mucosaHigh
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#208900, phenotype) Ataxia-telangiectasia; ATOMIM
2(*607585, gene) Ataxia-telangiectasia mutated gene; ATMOMIM
3T cell prolymphocytic leukaemia;leukemia;lymphoma;medulloblastoma;glioma;Ataxia-telangiectasiaCGP


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