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> Protein (NX_Q13323)
Protein (NX_Q13323)
Protein
Gene SymbolBIK to neXtProt (NX_Q13323)
DescriptionBcl-2-interacting killer
Chromosome22
Location22q13.2 (43506754 ~ 43525718) to Ensembl
Sequene Features : Isoforms 1, Variants 24, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of release of cytochrome c from mitochondria
.positive regulation of protein homooligomerization
.apoptotic mitochondrial changes
  + 3 more...
.N/A .mitochondrial membrane
.integral component of membrane
.endomembrane system
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 24 0
2014-09-19protein level
1 21 0
2014-05-27protein level
1 21 0
2014-02-25protein level
1 21 0
2013-12-09protein level
1 15 0
2013-11-01protein level
1 15 0
2013-09-12protein level
1 15 0
2013-08-17protein level
1 15 0
2013-07-15protein level
1 10 0
2013-06-11protein level
1 10 0
2013-02-12protein level
1 8 0
2012-12-20protein level
1 8 0
2012-10-30protein level
1 11 0
2012-10-07protein level
1 11 0
2012-08-24protein level
1 11 0
2012-07-28protein level
1 11 0
2012-06-08protein level
1 11 0
2012-05-07protein level
1 10 0
2012-04-10protein level
1 10 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13323-1
6 0 0 18004.0189
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-700794,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
2 EBI-700794,EBI-78035 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
3 EBI-700794,EBI-1003550 BCL2A1  
  .negative regulation of intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of apoptotic process
.intrinsic apoptotic signaling pathway in response to DNA damage
.protein heterodimerization activity
.protein homodimerization activity
.mitochondrial outer membrane
4 EBI-700794,EBI-707714 BCL2L2  
  .negative regulation of intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.Sertoli cell proliferation
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.extracellular exosome
.cytosol
.mitochondrial outer membrane
5 EBI-700794,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
bone marrow20
brain2
intestine38
kidney9
liver4
lung5
lymph135
lymph node89
prostate15
skin4
stomach31
testis4
tonsil117
Health State
TissuesTPM*
normal7
colorectal tumor8
glioma18
leukemia10
liver tumor10
lymphoma83
primitive neuroectodermal tumor of the CNS7
Developmental Stage
TissuesTPM*
adult3
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix3.4
bone marrow2.3
colon8.9
duodenum3.1
esophagus1.6
gallbladder3.1
kidney1.9
lymph node9.4
prostate8.6
salivary gland4.8
small intestine2.2
spleen1.3
stomach13.7
testis1.2
urinary bladder2.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603392, gene) Bcl2-interacting killer; BIKOMIM


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