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> Protein (NX_Q13330)
Protein (NX_Q13330)
Protein
Gene SymbolMTA1 to neXtProt (NX_Q13330)
DescriptionMetastasis-associated protein MTA1
Chromosome14
Location14q32.33 (105886159 ~ 105937066) to Ensembl
Sequene Features : Isoforms 3, Variants 76, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of nucleic acid-templated transcription
.positive regulation of protein autoubiquitination
.regulation of inflammatory response
  + 11 more...
.zinc ion binding
.transcription corepressor activity
.transcription coactivator activity
  + 5 more...
.intracellular membrane-bounded organelle
.NuRD complex
.microtubule
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 76 17
2014-09-19protein level
3 60 13
2014-05-27protein level
3 54 14
2014-02-25protein level
3 54 14
2013-12-09protein level
3 48 14
2013-11-01protein level
3 45 10
2013-09-12protein level
3 45 10
2013-08-17protein level
3 45 10
2013-07-15protein level
3 24 9
2013-06-11protein level
3 24 9
2013-02-12protein level
3 8 21
2012-12-20protein level
3 8 21
2012-10-30protein level
3 6 21
2012-10-07protein level
3 6 10
2012-08-24protein level
3 6 10
2012-07-28protein level
3 6 10
2012-06-08protein level
3 10 10
2012-05-07protein level
3 8 10
2012-04-10protein level
3 8 10
2012-01-13protein level
3 12 10
2011-12-20protein level
2 12 10
2011-11-11protein level
2 12 10
2011-08-23protein level
2 12 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13330-1
0 33 6 80735.0388
NX_Q13330-2
2 14 6 48986.3474
NX_Q13330-3
1 31 6 79142.3764
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714236,EBI-78473 ESR1  
  .cellular response to estradiol stimulus
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
  + 33 more...
.ATPase binding
.identical protein binding
.estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 14 more...
.transcriptionally active chromatin
.integral component of membrane
.membrane
  + 5 more...
2 EBI-714236,EBI-10178634 MAGEA11  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
3 EBI-714236,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
4 EBI-714236,EBI-620823 RBBP4  
  .regulation of cell cycle
.negative regulation of gene expression, epigenetic
.ATP-dependent chromatin remodeling
  + 15 more...
.histone deacetylase binding
.histone binding
.protein complex
.ESC/E(Z) complex
.CAF-1 complex
  + 6 more...
5 EBI-714236,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
6 EBI-714236,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
7 EBI-714236,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
8 EBI-714236,EBI-742808 KHDRBS2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
9 EBI-714236,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
10 EBI-714236,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
11 EBI-714236,EBI-301821 HDAC2  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of protein deacetylation
.negative regulation of canonical Wnt signaling pathway
  + 44 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 14 more...
.protein complex
.ESC/E(Z) complex
.NuRD complex
  + 8 more...
12 EBI-714236,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites200
blood49
bone97
bone marrow41
brain65
cervix144
connective tissue13
embryonic tissue117
eye138
heart22
intestine94
kidney47
liver24
lung116
lymph316
lymph node100
mammary gland119
muscle112
ovary187
pancreas65
pharynx49
placenta28
prostate47
salivary gland148
skin37
spleen37
stomach52
testis119
thyroid42
tonsil58
trachea19
uterus60
Health State
TissuesTPM*
normal66
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma120
colorectal tumor124
gastrointestinal tumor135
germ cell tumor53
glioma139
head and neck tumor52
kidney tumor101
leukemia158
liver tumor52
lung tumor155
lymphoma193
non-neoplasia20
ovarian tumor157
pancreatic tumor76
primitive neuroectodermal tumor of the CNS110
prostate cancer38
retinoblastoma215
skin tumor55
soft tissue/muscle tissue tumor95
uterine tumor133
Developmental Stage
TissuesTPM*
adult73
embryoid body85
blastocyst97
fetus111
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.4
adrenal gland22.6
appendix24.8
bone marrow23.2
cerebral cortex20
colon18.4
duodenum28.8
esophagus12.4
gallbladder17
heart muscle35.8
kidney20.4
liver9.2
lung25.6
lymph node24.8
ovary31
pancreas16.6
placenta20.2
prostate38.1
salivary gland32
skin28
small intestine26.1
spleen44
stomach30.3
testis44.7
thyroid gland17.6
urinary bladder16.9
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowLow
breastLow
bronchusLow
cerebellumHigh
cerebral cortexHigh
colonLow
duodenumLow
endometrium 1Low
epididymisLow
fallopian tubeLow
gallbladderLow
hippocampusMedium
kidneyLow
lateral ventricleMedium
liverLow
lungLow
lymph nodeLow
nasopharynxLow
ovaryLow
pancreasLow
parathyroid glandLow
placentaLow
rectumLow
salivary glandLow
seminal vesicleLow
skin 1Low
skin 2Low
small intestineLow
smooth muscleMedium
stomach 1Low
stomach 2Low
testisHigh
thyroid glandLow
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603526, gene) Metastasis-associated gene 1; MTA1OMIM


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