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> Protein (NX_Q13352)
Protein (NX_Q13352)
Protein
Gene SymbolITGB3BP to neXtProt (NX_Q13352)
DescriptionCentromere protein R
Chromosome1
Location1p31.3 (63906441 ~ 64059392) to Ensembl
Sequene Features : Isoforms 5, Variants 19, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.apoptotic signaling pathway
.cell division
.neurotrophin TRK receptor signaling pathway
  + 10 more...
.protein C-terminus binding
.signal transducer activity
.membrane
.cytosol
.cytoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 19 5
2014-09-19protein level
5 15 5
2014-05-27protein level
5 15 5
2014-02-25protein level
5 15 5
2013-12-09protein level
5 10 5
2013-11-01protein level
5 10 5
2013-09-12protein level
5 10 5
2013-08-17protein level
5 10 5
2013-07-15protein level
5 8 4
2013-06-11protein level
5 8 4
2013-02-12protein level
5 4 14
2012-12-20protein level
5 4 14
2012-10-30protein level
5 5 14
2012-10-07protein level
5 5 3
2012-08-24protein level
5 3 3
2012-07-28protein level
5 3 3
2012-06-08protein level
5 10 3
2012-05-07protein level
5 10 3
2012-04-10protein level
5 10 3
2012-01-13protein level
5 9 3
2011-12-20protein level
5 9 3
2011-11-11protein level
5 9 2
2011-08-23protein level
5 9 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13352-1
0 7 0 20181.3404
NX_Q13352-2
1 6 0 19289.8286
NX_Q13352-3
1 4 0 12616.336
NX_Q13352-4
0 2 0 6897.4542
NX_Q13352-5
3 7 0 24713.603
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-712105,EBI-638194 ARFIP2  
  .regulation of Arp2/3 complex-mediated actin nucleation
.ruffle organization
.actin cytoskeleton organization
  + 3 more...
.phosphatidylinositol-4-phosphate binding
.Rac GTPase binding
.GTP-dependent protein binding
.GTP binding
.trans-Golgi network membrane
.cell cortex
.plasma membrane
  + 2 more...
2 EBI-10175826,EBI-10232538 PIH1D2  
  .N/A .Ral GTPase binding .N/A
3 EBI-712105,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
4 EBI-712105,EBI-739994 COL4A3BP  
  .mitochondrion morphogenesis
.lipid homeostasis
.small molecule metabolic process
  + 14 more...
.ceramide binding
.phosphatidylinositol-4-phosphate binding
.ceramide transporter activity
.protein kinase activity
.cytosol
.Golgi apparatus
.endoplasmic reticulum membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder234
blood24
bone41
bone marrow82
brain13
connective tissue114
embryonic tissue37
esophagus99
eye9
heart22
intestine4
kidney9
liver48
lung23
lymph node44
mammary gland39
muscle18
nerve64
ovary9
pancreas18
placenta21
prostate26
salivary gland197
skin18
stomach10
testis52
thymus25
uterus21
Health State
TissuesTPM*
normal21
bladder carcinoma398
breast (mammary gland) tumor21
chondrosarcoma36
esophageal tumor115
gastrointestinal tumor16
germ cell tumor45
glioma37
kidney tumor14
leukemia52
liver tumor31
lung tumor9
lymphoma41
non-neoplasia10
ovarian tumor13
primitive neuroectodermal tumor of the CNS15
prostate cancer19
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor159
uterine tumor22
Developmental Stage
TissuesTPM*
adult20
embryoid body71
blastocyst32
fetus17
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.8
adrenal gland25.8
appendix20.1
bone marrow16.7
cerebral cortex7.4
colon20.4
duodenum12.7
esophagus14.7
gallbladder21
heart muscle10.4
kidney17.5
liver5.8
lung15
lymph node32.4
ovary27.6
pancreas9.4
placenta14
prostate18.4
salivary gland11.3
skin14.3
small intestine10.6
spleen14.5
stomach17.2
testis35.6
thyroid gland21.7
urinary bladder23.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605494, gene) Integrin, beta-3, binding protein of; ITGB3BPOMIM


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