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> Protein (NX_Q13362)
Protein (NX_Q13362)
Protein
Gene SymbolPPP2R5C to neXtProt (NX_Q13362)
DescriptionSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Chromosome14
Location14q32.31 (102228135 ~ 102394326) to Ensembl
Sequene Features : Isoforms 5, Variants 63, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.proteasome-mediated ubiquitin-dependent protein catabolic process
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.regulation of protein phosphatase type 2A activity
  + 3 more...
.protein phosphatase type 2A regulator activity .nucleus
.chromosome, centromeric region
.protein phosphatase type 2A complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 63 2
2014-09-19protein level
5 45 2
2014-05-27protein level
5 45 3
2014-02-25protein level
5 44 3
2013-12-09protein level
5 34 3
2013-11-01protein level
5 33 3
2013-09-12protein level
5 33 2
2013-08-17protein level
5 33 2
2013-07-15protein level
4 24 1
2013-06-11protein level
4 24 1
2013-02-12protein level
4 11 15
2012-12-20protein level
4 12 15
2012-10-30protein level
4 14 15
2012-10-07protein level
4 14 4
2012-08-24protein level
4 13 4
2012-07-28protein level
4 13 4
2012-06-08protein level
4 15 4
2012-05-07protein level
4 10 4
2012-04-10protein level
3 8 4
2012-01-13protein level
3 13 4
2011-12-20protein level
3 13 4
2011-11-11protein level
3 13 4
2011-08-23protein level
3 13 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13362-1
0 14 9 61021.3929
NX_Q13362-2
0 10 9 52591.3465
NX_Q13362-3
0 12 9 56624.3031
NX_Q13362-4
3 11 9 62714.7075
NX_Q13362-5
2 13 9 64251.1161
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1266176,EBI-1180783 CHEK2  
  .replicative senescence
.mitotic spindle assembly
.signal transduction involved in intra-S DNA damage checkpoint
  + 18 more...
.metal ion binding
.protein homodimerization activity
.identical protein binding
  + 4 more...
.PML body
.Golgi apparatus
.nucleoplasm
2 EBI-1266156,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-1266156,EBI-302388 PPP2R1A  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.peptidyl-serine dephosphorylation
.regulation of cell differentiation
  + 24 more...
.protein heterodimerization activity
.protein phosphatase type 2A regulator activity
.protein serine/threonine phosphatase activity
.antigen binding
.extracellular exosome
.membrane
.microtubule cytoskeleton
  + 5 more...
4 EBI-1266156,EBI-357094 PPP2R1B  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.apoptotic process involved in morphogenesis
.N/A .extracellular exosome
.membrane raft
5 EBI-1266156,EBI-1748945 IER3  
  .regulation of response to DNA damage stimulus
.regulation of reactive oxygen species metabolic process
.negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
  + 12 more...
.N/A .integral component of membrane
.nucleus
6 EBI-1266156,EBI-712311 PPP2CA  
  .positive regulation of protein serine/threonine kinase activity
.protein heterotrimerization
.meiotic cell cycle
  + 25 more...
.metal ion binding
.protein serine/threonine phosphatase activity
.extracellular exosome
.membrane
.microtubule cytoskeleton
  + 7 more...
7 EBI-1266156,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites50
bladder133
blood130
bone83
bone marrow225
brain113
cervix61
connective tissue107
ear186
embryonic tissue126
esophagus49
eye71
heart134
intestine73
kidney90
larynx42
liver82
lung104
lymph67
lymph node389
mammary gland72
mouth75
muscle65
nerve257
ovary88
pancreas70
parathyroid145
pharynx73
pituitary gland121
placenta105
prostate73
salivary gland98
skin137
spleen168
stomach135
testis170
thymus250
thyroid42
tonsil58
trachea424
umbilical cord72
uterus155
vascular116
Health State
TissuesTPM*
normal126
adrenal tumor158
bladder carcinoma170
breast (mammary gland) tumor53
cervical tumor86
chondrosarcoma120
colorectal tumor71
gastrointestinal tumor92
germ cell tumor250
glioma158
head and neck tumor59
kidney tumor145
leukemia148
liver tumor114
lung tumor126
lymphoma180
non-neoplasia103
ovarian tumor105
pancreatic tumor38
primitive neuroectodermal tumor of the CNS94
prostate cancer57
retinoblastoma64
skin tumor63
soft tissue/muscle tissue tumor111
uterine tumor66
Developmental Stage
TissuesTPM*
adult89
embryoid body157
blastocyst81
neonate160
fetus152
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue40.7
adrenal gland51.7
appendix70.4
bone marrow75.3
cerebral cortex54.8
colon59.4
duodenum38.5
esophagus66.3
gallbladder54.1
heart muscle89.5
kidney39.9
liver38.6
lung61.3
lymph node131.2
ovary52.6
pancreas23.6
placenta31.6
prostate39.6
salivary gland43.8
skin50.7
small intestine44.6
spleen59.3
stomach43.5
testis66
thyroid gland62.6
urinary bladder68.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601645, gene) Protein phosphatase 2, regulatory subunit b (b56), gamma; PPP2R5COMIM


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