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> Protein (NX_Q13363)
Protein (NX_Q13363)
Protein
Gene SymbolCTBP1 to neXtProt (NX_Q13363)
DescriptionC-terminal-binding protein 1
Chromosome4
Location4p16.3 (1205236 ~ 1243741) to Ensembl
Sequene Features : Isoforms 2, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription from RNA polymerase II promoter by histone modification
.negative regulation of histone H4 acetylation
.regulation of cell cycle
  + 9 more...
.repressing transcription factor binding
.NAD binding
.protein domain specific binding
  + 5 more...
.transcriptional repressor complex
.cytosol
.transcription factor complex
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 33 4
2014-09-19protein level
2 24 4
2014-05-27protein level
2 24 5
2014-02-25protein level
2 24 5
2013-12-09protein level
2 21 5
2013-11-01protein level
2 17 5
2013-09-12protein level
2 17 5
2013-08-17protein level
2 17 5
2013-07-15protein level
2 11 3
2013-06-11protein level
2 11 3
2013-02-12protein level
2 3 6
2012-12-20protein level
2 3 6
2012-10-30protein level
2 3 6
2012-10-07protein level
2 3 3
2012-08-24protein level
2 1 3
2012-07-28protein level
2 1 3
2012-06-08protein level
2 16 3
2012-05-07protein level
2 16 3
2012-04-10protein level
1 16 3
2012-01-13protein level
1 17 3
2011-12-20protein level
1 17 3
2011-11-11protein level
1 17 3
2011-08-23protein level
1 17 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13363-1
2 14 3 47505.3573
NX_Q13363-2
1 14 3 46375.7
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10171858,EBI-983612 FOXP2  
  .positive regulation of epithelial cell proliferation involved in lung morphogenesis
.righting reflex
.smooth muscle tissue development
  + 12 more...
.metal ion binding
.sequence-specific DNA binding
.protein homodimerization activity
  + 4 more...
.nucleus
2 EBI-908846,EBI-7232405 KLF4  
  .negative regulation of chemokine (C-X-C motif) ligand 2 production
.cellular response to peptide
.negative regulation of cell migration involved in sprouting angiogenesis
  + 36 more...
.transcription regulatory region DNA binding
.phosphatidylinositol 3-kinase regulator activity
.zinc ion binding
  + 7 more...
.transcription factor complex
.nucleoplasm
.nuclear chromatin
3 EBI-10171858,EBI-10190763 NOL4  
  .N/A .RNA binding .nucleolus
.nucleus
4 EBI-10171858,EBI-3893317 HOXB5  
  .embryonic skeletal system morphogenesis
.endothelial cell differentiation
.anterior/posterior pattern specification
.anatomical structure morphogenesis
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.nucleus
5 EBI-10171858,EBI-713568 MAPK9  
  .positive regulation of apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to tumor necrosis factor
  + 45 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.transcription factor binding
.ATP binding
.JUN kinase activity
.cytosol
.mitochondrion
.nucleoplasm
6 EBI-10171858,EBI-741533 CTBP2  
  .white fat cell differentiation
.positive regulation of retinoic acid receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 5 more...
.NAD binding
.oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
.transcription corepressor activity
  + 2 more...
.synapse
.cell junction
.transcriptional repressor complex
.nucleus
7 EBI-10171858,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
8 EBI-10171858,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
9 EBI-908846,EBI-2507362 HIC1  
  .positive regulation of DNA damage response, signal transduction by p53 class mediator
.negative regulation of Wnt signaling pathway
.Wnt signaling pathway
  + 5 more...
.metal ion binding
.sequence-specific DNA binding
.histone deacetylase binding
.sequence-specific DNA binding transcription factor activity
.cytoplasm
.nucleoplasm
.chromatin
10 EBI-10171858,EBI-714215 TGIF1  
  .retina development in camera-type eye
.negative regulation of retinoic acid receptor signaling pathway
.positive regulation of fibroblast proliferation
  + 14 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 2 more...
.nucleoplasm
11 EBI-10171858,EBI-2212355 CRY2  
  .negative regulation of glucocorticoid secretion
.negative regulation of glucocorticoid receptor signaling pathway
.regulation of sodium-dependent phosphate transport
  + 16 more...
.FAD binding
.ubiquitin binding
.phosphatase binding
  + 7 more...
.mitochondrion
.cytoplasm
.nucleus
.extracellular region
12 EBI-10171858,EBI-9051024 CEP68  
  .centrosome organization
.protein localization to organelle
.centriole-centriole cohesion
.protein domain specific binding
.protein kinase binding
.cell junction
.microtubule organizing center
.centrosome
  + 3 more...
13 EBI-908846,EBI-2813661 ZNF366  
  .response to estrogen
.negative regulation of intracellular estrogen receptor signaling pathway
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.estrogen receptor binding
.transcription corepressor activity
.DNA binding
.nucleus
14 EBI-908846,EBI-1790529 THAP11  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.DNA binding
.intercellular bridge
.cytoplasm
.nucleoplasm
15 EBI-10171858,EBI-6660790 NOL4L  
  .N/A .N/A .cytoplasm
.nucleoplasm
16 EBI-908846,EBI-3916399 HEMGN  
  .regulation of osteoblast differentiation
.cell differentiation
.multicellular organismal development
.N/A .nucleoplasm
17 EBI-10171858,EBI-6083685 BCAS3  
  .positive regulation of actin cytoskeleton reorganization
.regulation of establishment of cell polarity
.activation of GTPase activity
  + 16 more...
.beta-tubulin binding
.histone binding
.nuclear hormone receptor binding
  + 4 more...
.cell periphery
.intermediate filament cytoskeleton
.transcriptionally active chromatin
  + 4 more...
18 EBI-10171858,EBI-3396023 PLCB1  
  .positive regulation of CD24 biosynthetic process
.negative regulation of monocyte extravasation
.positive regulation of acrosome reaction
  + 30 more...
.protein homodimerization activity
.enzyme binding
.phosphatidylinositol-4,5-bisphosphate binding
  + 5 more...
.extracellular exosome
.nuclear membrane
.nuclear speck
  + 4 more...
19 EBI-10171858,EBI-750750 KLF12  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites25
blood49
bone69
bone marrow20
brain80
cervix61
connective tissue93
ear248
embryonic tissue126
eye95
heart55
intestine90
kidney47
liver63
lung89
lymph90
lymph node189
mammary gland99
muscle56
nerve64
ovary118
pancreas89
parathyroid145
pituitary gland60
placenta84
prostate63
salivary gland98
skin99
spleen56
stomach94
testis52
thymus12
thyroid42
tonsil117
trachea19
uterus51
vascular19
Health State
TissuesTPM*
normal67
adrenal tumor158
breast (mammary gland) tumor139
cervical tumor86
chondrosarcoma169
colorectal tumor44
gastrointestinal tumor67
germ cell tumor37
glioma121
head and neck tumor29
kidney tumor43
leukemia74
liver tumor104
lung tumor175
lymphoma96
non-neoplasia31
ovarian tumor78
pancreatic tumor95
primitive neuroectodermal tumor of the CNS102
prostate cancer67
retinoblastoma86
skin tumor127
soft tissue/muscle tissue tumor87
uterine tumor55
Developmental Stage
TissuesTPM*
adult72
embryoid body114
blastocyst179
fetus71
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue52.6
adrenal gland55
appendix65.9
bone marrow41
cerebral cortex65.8
colon57.1
duodenum63.7
esophagus48.2
gallbladder59.3
heart muscle55.4
kidney61.3
liver30.6
lung58.6
lymph node83.9
ovary52
pancreas57.2
placenta44
prostate72.4
salivary gland58.4
skin50.4
small intestine65.6
spleen99
stomach64.5
testis39.9
thyroid gland53.7
urinary bladder62.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeLow
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleMedium
skin 1Low
skin 2Low
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602618, gene) C-terminal-binding protein 1; CTBP1OMIM


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