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> Protein (NX_Q13415)
Protein (NX_Q13415)
Protein
Gene SymbolORC1 to neXtProt (NX_Q13415)
DescriptionOrigin recognition complex subunit 1
Chromosome1
Location1p32.3 (52838501 ~ 52870131) to Ensembl
Sequene Features : Isoforms 1, Variants 127, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.DNA replication initiation
.DNA replication
.mitotic cell cycle
  + 2 more...
.ATP binding
.chromatin binding
.DNA binding
.plasma membrane
.cytosol
.cytoplasm
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 127 15
2014-09-19protein level
1 102 15
2014-05-27protein level
1 102 15
2014-02-25protein level
1 101 15
2013-12-09protein level
1 77 15
2013-11-01protein level
1 76 15
2013-09-12protein level
1 76 15
2013-08-17protein level
1 76 15
2013-07-15protein level
1 61 15
2013-06-11protein level
1 61 15
2013-02-12protein level
1 37 15
2012-12-20protein level
1 37 15
2012-10-30protein level
1 47 15
2012-10-07protein level
1 47 15
2012-08-24protein level
1 35 15
2012-07-28protein level
1 35 15
2012-06-08protein level
1 36 15
2012-05-07protein level
1 36 15
2012-04-10protein level
1 36 15
2012-01-13protein level
1 26 15
2011-12-20protein level
1 26 15
2011-11-11protein level
1 26 14
2011-08-23protein level
1 26 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13415-1
39 0 0 97288.3196
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-374847,EBI-374928 ORC5  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
.G1/S transition of mitotic cell cycle
.ATP binding
.DNA replication origin binding
.nucleotide binding
.cytoplasm
.nuclear origin of replication recognition complex
.nucleoplasm
  + 2 more...
2 EBI-374847,EBI-456291 SKP2  
  .cellular response to cell-matrix adhesion
.regulation of cell cycle
.positive regulation of smooth muscle cell proliferation
  + 8 more...
.identical protein binding
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.aggresome
.cytosol
  + 4 more...
3 EBI-374847,EBI-374957 ORC2  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
  + 2 more...
.DNA replication origin binding .membrane
.plasma membrane
.centrosome
  + 6 more...
4 EBI-374847,EBI-706637 TERF2  
  .negative regulation of cellular senescence
.negative regulation of beta-galactosidase activity
.cellular senescence
  + 15 more...
.protein homodimerization activity
.telomeric DNA binding
.protein C-terminus binding
  + 2 more...
.Golgi apparatus
.cytoplasm
.nucleoplasm
  + 5 more...
5 EBI-374847,EBI-374916 ORC3  
  .neural precursor cell proliferation
.DNA replication
.mitotic cell cycle
.G1/S transition of mitotic cell cycle
.DNA replication origin binding .nuclear origin of replication recognition complex
.nucleoplasm
.origin recognition complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
blood40
bone13
bone marrow184
brain10
cervix20
embryonic tissue51
esophagus99
eye23
intestine25
kidney14
liver9
lung11
lymph135
mammary gland33
mouth30
muscle18
ovary29
pancreas4
placenta10
prostate5
skin23
stomach20
testis29
thymus200
thyroid21
uterus4
Health State
TissuesTPM*
normal8
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma12
colorectal tumor26
esophageal tumor115
gastrointestinal tumor59
germ cell tumor75
glioma37
head and neck tumor22
kidney tumor29
leukemia158
liver tumor10
lung tumor9
lymphoma138
pancreatic tumor9
primitive neuroectodermal tumor of the CNS70
prostate cancer9
retinoblastoma107
skin tumor23
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult19
embryoid body14
blastocyst113
neonate64
fetus14
infant85
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix3.5
bone marrow16
colon3.5
duodenum1.5
esophagus1.9
lymph node6.2
placenta2
skin1.4
small intestine2.1
spleen1
testis3.7
urinary bladder1.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#224690, phenotype) Meier-gorlin syndrome 1; MGORS1OMIM
2(*601902, gene) Origin recognition complex, subunit 1, s. cerevisiae, homolog of;OMIM


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