|
| Protein |
|
| Gene Symbol | ORC2 to neXtProt (NX_Q13416) |
| Description | Origin recognition complex subunit 2 |
| Chromosome | 2 |
| Location | 2q33.1 (201773696 ~ 201828403) to Ensembl |
|
|
Sequene Features : Isoforms 1, Variants 54, PTMs 5 to neXtProt Sequence Features
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|
Gene
Ontologies |
| GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
|
.DNA replication initiation
.DNA replication
.mitotic cell cycle
+ 2 more... |
.DNA replication origin binding |
.membrane
.plasma membrane
.centrosome
+ 6 more... |
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| |
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| Proteomic Evidences |
|
| |
|
| Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
|
| 2015-01-01 | | protein level | | | | | | | 1 |
| 54 |
| 5 |
|
| 2014-09-19 | | protein level | | | | | | | 1 |
| 43 |
| 5 |
|
| 2014-05-27 | | protein level | | | | | | | 1 |
| 43 |
| 5 |
|
| 2014-02-25 | | protein level | | | | | | | 1 |
| 42 |
| 5 |
|
| 2013-12-09 | | protein level | | | | | | | 1 |
| 32 |
| 5 |
|
| 2013-11-01 | | protein level | | | | | | | 1 |
| 30 |
| 5 |
|
| 2013-09-12 | | protein level | | | | | | | 1 |
| 30 |
| 5 |
|
| 2013-08-17 | | protein level | | | | | | | 1 |
| 30 |
| 5 |
|
| 2013-07-15 | | protein level | | | | | | | 1 |
| 16 |
| 5 |
|
| 2013-06-11 | | protein level | | | | | | | 1 |
| 16 |
| 5 |
|
| 2013-02-12 | | protein level | | | | | | | 1 |
| 10 |
| 5 |
|
| 2012-12-20 | | protein level | | | | | | | 1 |
| 10 |
| 5 |
|
| 2012-10-30 | | protein level | | | | | | | 1 |
| 15 |
| 5 |
|
| 2012-10-07 | | protein level | | | | | | | 1 |
| 15 |
| 5 |
|
| 2012-08-24 | | protein level | | | | | | | 1 |
| 11 |
| 5 |
|
| 2012-07-28 | | protein level | | | | | | | 1 |
| 11 |
| 5 |
|
| 2012-06-08 | | protein level | | | | | | | 1 |
| 14 |
| 5 |
|
| 2012-05-07 | | protein level | | | | | | | 1 |
| 13 |
| 5 |
|
| 2012-04-10 | | protein level | | | | | | | 1 |
| 13 |
| 5 |
|
| 2012-01-13 | | protein level | | | | | | | 1 |
| 8 |
| 5 |
|
| 2011-12-20 | | protein level | | | | | | | 1 |
| 8 |
| 5 |
|
| 2011-11-11 | | protein level | | | | | | | 1 |
| 8 |
| 3 |
|
| 2011-08-23 | | protein level | | | | | | | 1 |
| 8 |
| 3 |
|
|
| |
|
| Protein Isoforms |
|
| |
| |
|
| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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|
| |
|
| Interacting Partners |
|
| |
|
| No. |
Exp. ref. |
Symbol |
|
PE |
Pr |
Ab |
Di |
|
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
|
| 1 |
EBI-374957,EBI-374928 |
ORC5 |
|
| | | | |
.DNA replication initiation
.DNA replication
.mitotic cell cycle
.G1/S transition of mitotic cell cycle |
.ATP binding
.DNA replication origin binding
.nucleotide binding |
.cytoplasm
.nuclear origin of replication recognition complex
.nucleoplasm
+ 2 more... |
|
| 2 |
EBI-374957,EBI-374889 |
ORC4 |
|
| | | | |
.DNA replication initiation
.DNA replication
.mitotic cell cycle
.G1/S transition of mitotic cell cycle |
.ATP binding
.DNA replication origin binding
.nucleotide binding |
.actin cytoskeleton
.cytoplasm
.nucleolus
+ 4 more... |
|
| 3 |
EBI-374957,EBI-355153 |
MCM3 |
|
| | | | |
.DNA strand elongation involved in DNA replication
.DNA replication initiation
.DNA replication
+ 2 more... |
.ATP binding
.DNA helicase activity
.DNA binding |
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.MCM complex
+ 5 more... |
|
| 4 |
EBI-374957,EBI-374847 |
ORC1 |
|
| | | | |
.DNA replication initiation
.DNA replication
.mitotic cell cycle
+ 2 more... |
.ATP binding
.chromatin binding
.DNA binding |
.plasma membrane
.cytosol
.cytoplasm
+ 5 more... |
|
| 5 |
EBI-374957,EBI-706637 |
TERF2 |
|
| | | | |
.negative regulation of cellular senescence
.negative regulation of beta-galactosidase activity
.cellular senescence
+ 15 more... |
.protein homodimerization activity
.telomeric DNA binding
.protein C-terminus binding
+ 2 more... |
.Golgi apparatus
.cytoplasm
.nucleoplasm
+ 5 more... |
|
| 6 |
EBI-374957,EBI-374912 |
MCM10 |
|
| | | | |
.cell proliferation
.DNA replication initiation
.DNA replication
+ 2 more... |
.metal ion binding
.identical protein binding
.single-stranded DNA binding
+ 2 more... |
.replication fork protection complex
.cytoplasm
.nucleolus
+ 2 more... |
|
| 7 |
EBI-374957,EBI-374880 |
CDC5L |
|
| | | | |
.signal transduction involved in DNA damage checkpoint
.gene expression
.RNA splicing
+ 4 more... |
.WD40-repeat domain binding
.poly(A) RNA binding
.chromatin binding
.DNA binding |
.catalytic step 2 spliceosome
.nuclear speck
.membrane
+ 5 more... |
|
|
| |
|
| EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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| |
|
| Body Sites | |
| Tissues | TPM* | |
|
| adrenal gland | 91 | |
| ascites | 50 | |
| bladder | 66 | |
| blood | 24 | |
| bone | 41 | |
| bone marrow | 61 | |
| brain | 26 | |
| cervix | 20 | |
| connective tissue | 20 | |
| embryonic tissue | 51 | |
| esophagus | 148 | |
| eye | 14 | |
| intestine | 21 | |
| kidney | 23 | |
| liver | 34 | |
| lung | 26 | |
| lymph | 22 | |
| mammary gland | 39 | |
| mouth | 30 | |
| muscle | 28 | |
| nerve | 193 | |
| parathyroid | 145 | |
| pituitary gland | 121 | |
| placenta | 31 | |
| prostate | 26 | |
| salivary gland | 98 | |
| skin | 9 | |
| spleen | 37 | |
| stomach | 62 | |
| testis | 119 | |
| thymus | 112 | |
| thyroid | 21 | |
| uterus | 17 | |
| vascular | 38 | |
|
| Health State | |
| Tissues | TPM* | |
|
| normal | 29 | |
| bladder carcinoma | 56 | |
| breast (mammary gland) tumor | 42 | |
| cervical tumor | 28 | |
| chondrosarcoma | 48 | |
| colorectal tumor | 17 | |
| esophageal tumor | 173 | |
| gastrointestinal tumor | 59 | |
| germ cell tumor | 49 | |
| head and neck tumor | 14 | |
| leukemia | 52 | |
| liver tumor | 41 | |
| lung tumor | 19 | |
| lymphoma | 69 | |
| non-neoplasia | 10 | |
| primitive neuroectodermal tumor of the CNS | 15 | |
| prostate cancer | 9 | |
| skin tumor | 7 | |
| uterine tumor | 44 | |
|
| Developmental Stage | |
| Tissues | TPM* | |
|
| adult | 32 | |
| embryoid body | 71 | |
| blastocyst | 65 | |
| neonate | 32 | |
| fetus | 23 | |
| infant | 42 | |
| juvenile | 35 | |
|
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
| |
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| Expression level of Protein (ref. Human Protein Atlas) |
|
| |
|
| RNA-Seq. | |
| Tissues | FPKM | |
|
| adipose tissue | 6.1 | |
| adrenal gland | 9.3 | |
| appendix | 13.5 | |
| bone marrow | 7.3 | |
| cerebral cortex | 7.8 | |
| colon | 11.4 | |
| duodenum | 12.1 | |
| esophagus | 7.8 | |
| gallbladder | 8.5 | |
| heart muscle | 8.7 | |
| kidney | 7.6 | |
| liver | 7 | |
| lung | 9.1 | |
| lymph node | 14.4 | |
| ovary | 11 | |
| pancreas | 2.8 | |
| placenta | 9.3 | |
| prostate | 10.4 | |
| salivary gland | 7.3 | |
| skin | 13.6 | |
| small intestine | 12.4 | |
| spleen | 11.6 | |
| stomach | 10.6 | |
| testis | 28.8 | |
| thyroid gland | 12.5 | |
| urinary bladder | 8.9 | |
|
| Tissues | |
| Tissues | Expression level |
|
| appendix | Low | |
| breast | Low | |
| cerebral cortex | Low | |
| colon | Low | |
| duodenum | Low | |
| endometrium 1 | Low | |
| endometrium 2 | Low | |
| fallopian tube | Low | |
| gallbladder | Low | |
| kidney | Low | |
| lung | Low | |
| lymph node | Medium | |
| oral mucosa | Low | |
| ovary | Low | |
| placenta | Low | |
| rectum | Low | |
| salivary gland | Low | |
| skin 1 | Low | |
| small intestine | Low | |
| soft tissue 1 | Low | |
| stomach 2 | Low | |
| testis | High | |
| thyroid gland | Low | |
| tonsil | Medium | |
| urinary bladder | Low | |
| vagina | Low | |
|
| Cancer | |
| Tumor | Number of patients and Staining levels | |
| breast cancer | |
| carcinoid | |
| cervical cancer | |
| colorectal cancer | |
| endometrial cancer | |
| glioma | |
| head and neck cancer | |
| liver cancer | |
| lung cancer | |
| lymphoma | |
| melanoma | |
| ovarian cancer | |
| pancreatic cancer | |
| prostate cancer | |
| renal cancer | |
| skin cancer | |
| stomach cancer | |
| testis cancer | |
| thyroid cancer | |
| urothelial cancer | |
|
| RNA-seq colour codes |
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|
Highly expressed RNAs (FPKM >50) | |
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Moderately expressed RNAs (50> FPKM >10) | |
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Lower expressed RNAs (10> FPKM >1) | |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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| Expression level colour codes |
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Highly expressed protein | |
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Moderately expressed protein | |
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Lower expressed protein |
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| Staining level colour codes |
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Highly expressed protein | |
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Moderately expressed protein | |
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Lower expressed protein | |
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Not Detected |
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| Disease |
|
| |
|
| No. | Disease Description | Ref. |
|
| 1 | (*601182, gene) Origin recognition complex, subunit 2, s. cerevisiae, homolog of; | OMIM |
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> Protein (NX_Q13416)