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> Protein (NX_Q13416)
Protein (NX_Q13416)
Protein
Gene SymbolORC2 to neXtProt (NX_Q13416)
DescriptionOrigin recognition complex subunit 2
Chromosome2
Location2q33.1 (201773696 ~ 201828403) to Ensembl
Sequene Features : Isoforms 1, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.DNA replication initiation
.DNA replication
.mitotic cell cycle
  + 2 more...
.DNA replication origin binding .membrane
.plasma membrane
.centrosome
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 54 5
2014-09-19protein level
1 43 5
2014-05-27protein level
1 43 5
2014-02-25protein level
1 42 5
2013-12-09protein level
1 32 5
2013-11-01protein level
1 30 5
2013-09-12protein level
1 30 5
2013-08-17protein level
1 30 5
2013-07-15protein level
1 16 5
2013-06-11protein level
1 16 5
2013-02-12protein level
1 10 5
2012-12-20protein level
1 10 5
2012-10-30protein level
1 15 5
2012-10-07protein level
1 15 5
2012-08-24protein level
1 11 5
2012-07-28protein level
1 11 5
2012-06-08protein level
1 14 5
2012-05-07protein level
1 13 5
2012-04-10protein level
1 13 5
2012-01-13protein level
1 8 5
2011-12-20protein level
1 8 5
2011-11-11protein level
1 8 3
2011-08-23protein level
1 8 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13416-1
23 0 0 65930.7086
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-374957,EBI-374928 ORC5  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
.G1/S transition of mitotic cell cycle
.ATP binding
.DNA replication origin binding
.nucleotide binding
.cytoplasm
.nuclear origin of replication recognition complex
.nucleoplasm
  + 2 more...
2 EBI-374957,EBI-374889 ORC4  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
.G1/S transition of mitotic cell cycle
.ATP binding
.DNA replication origin binding
.nucleotide binding
.actin cytoskeleton
.cytoplasm
.nucleolus
  + 4 more...
3 EBI-374957,EBI-355153 MCM3  
  .DNA strand elongation involved in DNA replication
.DNA replication initiation
.DNA replication
  + 2 more...
.ATP binding
.DNA helicase activity
.DNA binding
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.MCM complex
  + 5 more...
4 EBI-374957,EBI-374847 ORC1  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
  + 2 more...
.ATP binding
.chromatin binding
.DNA binding
.plasma membrane
.cytosol
.cytoplasm
  + 5 more...
5 EBI-374957,EBI-706637 TERF2  
  .negative regulation of cellular senescence
.negative regulation of beta-galactosidase activity
.cellular senescence
  + 15 more...
.protein homodimerization activity
.telomeric DNA binding
.protein C-terminus binding
  + 2 more...
.Golgi apparatus
.cytoplasm
.nucleoplasm
  + 5 more...
6 EBI-374957,EBI-374912 MCM10  
  .cell proliferation
.DNA replication initiation
.DNA replication
  + 2 more...
.metal ion binding
.identical protein binding
.single-stranded DNA binding
  + 2 more...
.replication fork protection complex
.cytoplasm
.nucleolus
  + 2 more...
7 EBI-374957,EBI-374880 CDC5L  
  .signal transduction involved in DNA damage checkpoint
.gene expression
.RNA splicing
  + 4 more...
.WD40-repeat domain binding
.poly(A) RNA binding
.chromatin binding
.DNA binding
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites50
bladder66
blood24
bone41
bone marrow61
brain26
cervix20
connective tissue20
embryonic tissue51
esophagus148
eye14
intestine21
kidney23
liver34
lung26
lymph22
mammary gland39
mouth30
muscle28
nerve193
parathyroid145
pituitary gland121
placenta31
prostate26
salivary gland98
skin9
spleen37
stomach62
testis119
thymus112
thyroid21
uterus17
vascular38
Health State
TissuesTPM*
normal29
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma48
colorectal tumor17
esophageal tumor173
gastrointestinal tumor59
germ cell tumor49
head and neck tumor14
leukemia52
liver tumor41
lung tumor19
lymphoma69
non-neoplasia10
primitive neuroectodermal tumor of the CNS15
prostate cancer9
skin tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult32
embryoid body71
blastocyst65
neonate32
fetus23
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.1
adrenal gland9.3
appendix13.5
bone marrow7.3
cerebral cortex7.8
colon11.4
duodenum12.1
esophagus7.8
gallbladder8.5
heart muscle8.7
kidney7.6
liver7
lung9.1
lymph node14.4
ovary11
pancreas2.8
placenta9.3
prostate10.4
salivary gland7.3
skin13.6
small intestine12.4
spleen11.6
stomach10.6
testis28.8
thyroid gland12.5
urinary bladder8.9
Tissues
TissuesExpression level
appendixLow
breastLow
cerebral cortexLow
colonLow
duodenumLow
endometrium 1Low
endometrium 2Low
fallopian tubeLow
gallbladderLow
kidneyLow
lungLow
lymph nodeMedium
oral mucosaLow
ovaryLow
placentaLow
rectumLow
salivary glandLow
skin 1Low
small intestineLow
soft tissue 1Low
stomach 2Low
testisHigh
thyroid glandLow
tonsilMedium
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601182, gene) Origin recognition complex, subunit 2, s. cerevisiae, homolog of;OMIM


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