|
Protein |
|
Gene Symbol | ORC2 to neXtProt (NX_Q13416) |
Description | Origin recognition complex subunit 2 |
Chromosome | 2 |
Location | 2q33.1 (201773696 ~ 201828403) to Ensembl |
|
|
Sequene Features : Isoforms 1, Variants 54, PTMs 5 to neXtProt Sequence Features
|
|
Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
|
.DNA replication initiation .DNA replication .mitotic cell cycle + 2 more... |
.DNA replication origin binding |
.membrane .plasma membrane .centrosome + 6 more... |
|
|
| |
|
Proteomic Evidences |
|
| |
|
Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
|
2015-01-01 | | protein level | | | | | | | 1 |
| 54 |
| 5 |
|
2014-09-19 | | protein level | | | | | | | 1 |
| 43 |
| 5 |
|
2014-05-27 | | protein level | | | | | | | 1 |
| 43 |
| 5 |
|
2014-02-25 | | protein level | | | | | | | 1 |
| 42 |
| 5 |
|
2013-12-09 | | protein level | | | | | | | 1 |
| 32 |
| 5 |
|
2013-11-01 | | protein level | | | | | | | 1 |
| 30 |
| 5 |
|
2013-09-12 | | protein level | | | | | | | 1 |
| 30 |
| 5 |
|
2013-08-17 | | protein level | | | | | | | 1 |
| 30 |
| 5 |
|
2013-07-15 | | protein level | | | | | | | 1 |
| 16 |
| 5 |
|
2013-06-11 | | protein level | | | | | | | 1 |
| 16 |
| 5 |
|
2013-02-12 | | protein level | | | | | | | 1 |
| 10 |
| 5 |
|
2012-12-20 | | protein level | | | | | | | 1 |
| 10 |
| 5 |
|
2012-10-30 | | protein level | | | | | | | 1 |
| 15 |
| 5 |
|
2012-10-07 | | protein level | | | | | | | 1 |
| 15 |
| 5 |
|
2012-08-24 | | protein level | | | | | | | 1 |
| 11 |
| 5 |
|
2012-07-28 | | protein level | | | | | | | 1 |
| 11 |
| 5 |
|
2012-06-08 | | protein level | | | | | | | 1 |
| 14 |
| 5 |
|
2012-05-07 | | protein level | | | | | | | 1 |
| 13 |
| 5 |
|
2012-04-10 | | protein level | | | | | | | 1 |
| 13 |
| 5 |
|
2012-01-13 | | protein level | | | | | | | 1 |
| 8 |
| 5 |
|
2011-12-20 | | protein level | | | | | | | 1 |
| 8 |
| 5 |
|
2011-11-11 | | protein level | | | | | | | 1 |
| 8 |
| 3 |
|
2011-08-23 | | protein level | | | | | | | 1 |
| 8 |
| 3 |
|
|
| |
|
Protein Isoforms |
|
| |
|
|
| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
|
|
| |
|
Interacting Partners |
|
| |
|
No. |
Exp. ref. |
Symbol |
|
PE |
Pr |
Ab |
Di |
|
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
|
1 |
EBI-374957,EBI-374928 |
ORC5 |
|
| | | | |
.DNA replication initiation .DNA replication .mitotic cell cycle .G1/S transition of mitotic cell cycle |
.ATP binding .DNA replication origin binding .nucleotide binding |
.cytoplasm .nuclear origin of replication recognition complex .nucleoplasm + 2 more... |
|
2 |
EBI-374957,EBI-374889 |
ORC4 |
|
| | | | |
.DNA replication initiation .DNA replication .mitotic cell cycle .G1/S transition of mitotic cell cycle |
.ATP binding .DNA replication origin binding .nucleotide binding |
.actin cytoskeleton .cytoplasm .nucleolus + 4 more... |
|
3 |
EBI-374957,EBI-355153 |
MCM3 |
|
| | | | |
.DNA strand elongation involved in DNA replication .DNA replication initiation .DNA replication + 2 more... |
.ATP binding .DNA helicase activity .DNA binding |
.perinuclear region of cytoplasm .intracellular membrane-bounded organelle .MCM complex + 5 more... |
|
4 |
EBI-374957,EBI-374847 |
ORC1 |
|
| | | | |
.DNA replication initiation .DNA replication .mitotic cell cycle + 2 more... |
.ATP binding .chromatin binding .DNA binding |
.plasma membrane .cytosol .cytoplasm + 5 more... |
|
5 |
EBI-374957,EBI-706637 |
TERF2 |
|
| | | | |
.negative regulation of cellular senescence .negative regulation of beta-galactosidase activity .cellular senescence + 15 more... |
.protein homodimerization activity .telomeric DNA binding .protein C-terminus binding + 2 more... |
.Golgi apparatus .cytoplasm .nucleoplasm + 5 more... |
|
6 |
EBI-374957,EBI-374912 |
MCM10 |
|
| | | | |
.cell proliferation .DNA replication initiation .DNA replication + 2 more... |
.metal ion binding .identical protein binding .single-stranded DNA binding + 2 more... |
.replication fork protection complex .cytoplasm .nucleolus + 2 more... |
|
7 |
EBI-374957,EBI-374880 |
CDC5L |
|
| | | | |
.signal transduction involved in DNA damage checkpoint .gene expression .RNA splicing + 4 more... |
.WD40-repeat domain binding .poly(A) RNA binding .chromatin binding .DNA binding |
.catalytic step 2 spliceosome .nuclear speck .membrane + 5 more... |
|
|
| |
|
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
|
| |
|
Body Sites | |
Tissues | TPM* | |
|
adrenal gland | 91 | |
ascites | 50 | |
bladder | 66 | |
blood | 24 | |
bone | 41 | |
bone marrow | 61 | |
brain | 26 | |
cervix | 20 | |
connective tissue | 20 | |
embryonic tissue | 51 | |
esophagus | 148 | |
eye | 14 | |
intestine | 21 | |
kidney | 23 | |
liver | 34 | |
lung | 26 | |
lymph | 22 | |
mammary gland | 39 | |
mouth | 30 | |
muscle | 28 | |
nerve | 193 | |
parathyroid | 145 | |
pituitary gland | 121 | |
placenta | 31 | |
prostate | 26 | |
salivary gland | 98 | |
skin | 9 | |
spleen | 37 | |
stomach | 62 | |
testis | 119 | |
thymus | 112 | |
thyroid | 21 | |
uterus | 17 | |
vascular | 38 | |
|
Health State | |
Tissues | TPM* | |
|
normal | 29 | |
bladder carcinoma | 56 | |
breast (mammary gland) tumor | 42 | |
cervical tumor | 28 | |
chondrosarcoma | 48 | |
colorectal tumor | 17 | |
esophageal tumor | 173 | |
gastrointestinal tumor | 59 | |
germ cell tumor | 49 | |
head and neck tumor | 14 | |
leukemia | 52 | |
liver tumor | 41 | |
lung tumor | 19 | |
lymphoma | 69 | |
non-neoplasia | 10 | |
primitive neuroectodermal tumor of the CNS | 15 | |
prostate cancer | 9 | |
skin tumor | 7 | |
uterine tumor | 44 | |
|
Developmental Stage | |
Tissues | TPM* | |
|
adult | 32 | |
embryoid body | 71 | |
blastocyst | 65 | |
neonate | 32 | |
fetus | 23 | |
infant | 42 | |
juvenile | 35 | |
|
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
| |
|
Expression level of Protein (ref. Human Protein Atlas) |
|
| |
|
RNA-Seq. | |
Tissues | FPKM | |
|
adipose tissue | 6.1 | |
adrenal gland | 9.3 | |
appendix | 13.5 | |
bone marrow | 7.3 | |
cerebral cortex | 7.8 | |
colon | 11.4 | |
duodenum | 12.1 | |
esophagus | 7.8 | |
gallbladder | 8.5 | |
heart muscle | 8.7 | |
kidney | 7.6 | |
liver | 7 | |
lung | 9.1 | |
lymph node | 14.4 | |
ovary | 11 | |
pancreas | 2.8 | |
placenta | 9.3 | |
prostate | 10.4 | |
salivary gland | 7.3 | |
skin | 13.6 | |
small intestine | 12.4 | |
spleen | 11.6 | |
stomach | 10.6 | |
testis | 28.8 | |
thyroid gland | 12.5 | |
urinary bladder | 8.9 | |
|
Tissues | |
Tissues | Expression level |
|
appendix | Low | |
breast | Low | |
cerebral cortex | Low | |
colon | Low | |
duodenum | Low | |
endometrium 1 | Low | |
endometrium 2 | Low | |
fallopian tube | Low | |
gallbladder | Low | |
kidney | Low | |
lung | Low | |
lymph node | Medium | |
oral mucosa | Low | |
ovary | Low | |
placenta | Low | |
rectum | Low | |
salivary gland | Low | |
skin 1 | Low | |
small intestine | Low | |
soft tissue 1 | Low | |
stomach 2 | Low | |
testis | High | |
thyroid gland | Low | |
tonsil | Medium | |
urinary bladder | Low | |
vagina | Low | |
|
Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
|
RNA-seq colour codes |
|
Highly expressed RNAs (FPKM >50) |
|
Moderately expressed RNAs (50> FPKM >10) |
|
Lower expressed RNAs (10> FPKM >1) |
|
The lowest expressed RNAs (FPKM value of 0 or 1) |
|
Expression level colour codes |
|
Highly expressed protein |
|
Moderately expressed protein |
|
Lower expressed protein |
|
Staining level colour codes |
|
Highly expressed protein |
|
Moderately expressed protein |
|
Lower expressed protein |
|
Not Detected |
|
|
| |
|
Disease |
|
| |
|
No. | Disease Description | Ref. |
|
1 | (*601182, gene) Origin recognition complex, subunit 2, s. cerevisiae, homolog of; | OMIM |
|
| |
|