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> Protein (NX_Q13422)
Protein (NX_Q13422)
Protein
Gene SymbolIKZF1 to neXtProt (NX_Q13422)
DescriptionDNA-binding protein Ikaros
Chromosome7
Location7p12.2 (50343720 ~ 50472799) to Ensembl
Sequene Features : Isoforms 8, Variants 84, PTMs 23 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 84 23
2014-09-19protein level
8 54 23
2014-05-27protein level
8 53 24
2014-02-25protein level
8 53 24
2013-12-09protein level
8 51 24
2013-11-01protein level
8 51 24
2013-09-12protein level
7 51 23
2013-08-17protein level
7 51 23
2013-07-15protein level
7 33 18
2013-06-11protein level
7 33 18
2013-02-12protein level
7 11 115
2012-12-20protein level
7 11 115
2012-10-30protein level
7 11 115
2012-10-07protein level
7 11 19
2012-08-24protein level
7 7 19
2012-07-28protein level
7 7 19
2012-06-08protein level
7 16 19
2012-05-07protein level
7 11 19
2012-04-10protein level
7 11 19
2012-01-13protein level
7 10 19
2011-12-20protein level
7 10 19
2011-11-11protein level
7 10 19
2011-08-23protein level
7 10 19
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13422-1
0 20 4 57491.2424
NX_Q13422-2
1 15 3 48257.908
NX_Q13422-3
0 18 3 47603.3455
NX_Q13422-4
1 16 3 43065.2701
NX_Q13422-5
0 17 0 41202.2003
NX_Q13422-6
0 12 0 31968.8659
NX_Q13422-7
0 19 3 52671.9567
NX_Q13422-8
0 9 3 24454.4567
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-745305,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-745305,EBI-8646694 DCX  
  .dendrite morphogenesis
.axon extension
.protein autophosphorylation
  + 8 more...
.protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.microtubule binding
  + 2 more...
.neuron projection
.microtubule associated complex
.microtubule
  + 4 more...
3 EBI-745305,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
4 EBI-745305,EBI-1055693 RAD51D  
  .strand invasion
.reciprocal meiotic recombination
.DNA repair
  + 2 more...
.gamma-tubulin binding
.DNA-dependent ATPase activity
.ATP binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.centrosome
.cytoplasm
  + 3 more...
5 EBI-745305,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
6 EBI-745305,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
7 EBI-745305,EBI-359310 PSMA4  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.intracellular membrane-bounded organelle
.proteasome core complex, alpha-subunit complex
  + 8 more...
8 EBI-745305,EBI-351257 DDX6  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.cytoplasmic mRNA processing body assembly
.viral RNA genome packaging
  + 4 more...
.poly(A) RNA binding
.protein domain specific binding
.ATP binding
  + 3 more...
.intracellular membrane-bounded organelle
.RISC complex
.membrane
  + 5 more...
9 EBI-745305,EBI-741533 CTBP2  
  .white fat cell differentiation
.positive regulation of retinoic acid receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 5 more...
.NAD binding
.oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
.transcription corepressor activity
  + 2 more...
.synapse
.cell junction
.transcriptional repressor complex
.nucleus
10 EBI-745305,EBI-724442 RWDD2B  
  .N/A .N/A .N/A
11 EBI-745305,EBI-456371 CKS1B  
  .cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
12 EBI-745305,EBI-6657662 FGF12  
  .negative regulation of cation channel activity
.regulation of sodium ion transmembrane transporter activity
.regulation of sodium ion transmembrane transport
  + 12 more...
.ion channel binding
.sodium channel regulator activity
.heparin binding
.growth factor activity
.nucleus
.extracellular space
13 EBI-745305,EBI-356900 SNRPF  
  .activation of mitophagy in response to mitochondrial depolarization
.ncRNA metabolic process
.mRNA 3'-end processing
  + 7 more...
.RNA binding .catalytic step 2 spliceosome
.SMN-Sm protein complex
.pICln-Sm protein complex
  + 10 more...
14 EBI-745305,EBI-714236 MTA1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of protein autoubiquitination
.regulation of inflammatory response
  + 11 more...
.zinc ion binding
.transcription corepressor activity
.transcription coactivator activity
  + 5 more...
.intracellular membrane-bounded organelle
.NuRD complex
.microtubule
  + 4 more...
15 EBI-745305,EBI-10171858 CTBP1  
  .negative regulation of transcription from RNA polymerase II promoter by histone modification
.negative regulation of histone H4 acetylation
.regulation of cell cycle
  + 9 more...
.repressing transcription factor binding
.NAD binding
.protein domain specific binding
  + 5 more...
.transcriptional repressor complex
.cytosol
.transcription factor complex
  + 2 more...
16 EBI-745305,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
17 EBI-745305,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
18 EBI-745305,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
19 EBI-745305,EBI-751647 WTAP  
  .mRNA methylation
.RNA splicing
.cell cycle
  + 2 more...
.N/A .MIS complex
.nuclear membrane
.nuclear speck
  + 2 more...
20 EBI-745305,EBI-399257 MORF4L2  
  .positive regulation of striated muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.regulation of growth
  + 4 more...
.N/A .nucleolus
.nucleoplasm
21 EBI-745305,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
22 EBI-745305,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
23 EBI-745305,EBI-745689 FAM214B  
  .N/A .N/A .nucleus
24 EBI-745305,EBI-715898 C1orf174  
  .N/A .N/A .nucleus
25 EBI-745305,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
26 EBI-745305,EBI-745707 GMCL1P1  
  .cell differentiation
.protein ubiquitination
.spermatogenesis
.multicellular organismal development
.N/A .nuclear matrix
27 EBI-745305,EBI-742259 LMO3  
  .positive regulation of glucocorticoid receptor signaling pathway
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of fat cell differentiation
  + 3 more...
.zinc ion binding .cytoplasm
28 EBI-745305,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
29 EBI-745305,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
30 EBI-745305,EBI-749432 DYRK2  
  .negative regulation of NFAT protein import into nucleus
.positive regulation of glycogen biosynthetic process
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 4 more...
.ubiquitin binding
.manganese ion binding
.ATP binding
  + 4 more...
.ribonucleoprotein complex
.cytoplasm
.nucleoplasm
  + 2 more...
31 EBI-745305,EBI-348259 MCRS1  
  .histone H4-K16 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
  + 6 more...
.N/A .MLL1 complex
.Ino80 complex
.cell junction
  + 5 more...
32 EBI-745305,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
33 EBI-745305,EBI-741729 FRMD6  
  .cellular protein localization
.regulation of actin filament-based process
.apical constriction
.N/A .apical junction complex
.plasma membrane
.cytoskeleton
.cytoplasm
34 EBI-745305,EBI-6658697 ALKBH3  
  .oxidative single-stranded DNA demethylation
.cell proliferation
.DNA dealkylation involved in DNA repair
.DNA repair
.cytosine C-5 DNA demethylase activity
.DNA-N1-methyladenine dioxygenase activity
.L-ascorbic acid binding
.ferrous iron binding
.mitochondrion
.cytoplasm
.nucleoplasm
.nucleus
35 EBI-745305,EBI-1045072 PNKP  
  .polynucleotide 3' dephosphorylation
.DNA 3' dephosphorylation involved in DNA repair
.nucleic acid phosphodiester bond hydrolysis
  + 9 more...
.ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
.polynucleotide 3'-phosphatase activity
.nucleotide kinase activity
  + 5 more...
.membrane
.nucleolus
.nucleoplasm
.nucleus
36 EBI-745305,EBI-745392 SYT17  
  .positive regulation of dendrite extension
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.clathrin binding
.syntaxin binding
.calcium-dependent phospholipid binding
.calcium ion binding
.plasma membrane
.trans-Golgi network
37 EBI-745305,EBI-395927 NOC4L  
  .rRNA processing
.maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
.poly(A) RNA binding .small-subunit processome
.nuclear membrane
.Noc4p-Nop14p complex
  + 3 more...
38 EBI-745305,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
39 EBI-745305,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
40 EBI-745305,EBI-372911 SPATC1L  
  .N/A .N/A .N/A
41 EBI-745305,EBI-1047335 ISCU  
  .protein maturation by iron-sulfur cluster transfer
.[2Fe-2S] cluster assembly
.small molecule metabolic process
  + 3 more...
.4 iron, 4 sulfur cluster binding
.2 iron, 2 sulfur cluster binding
.iron-sulfur transferase activity
  + 3 more...
.cytosol
.mitochondrial matrix
.mitochondrion
  + 2 more...
42 EBI-745305,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
.nucleus
43 EBI-745305,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
44 EBI-745305,EBI-715389 C8orf33  
  .N/A .N/A .N/A
45 EBI-745305,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
46 EBI-745305,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
47 EBI-745305,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
48 EBI-745305,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
49 EBI-745305,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
50 EBI-745305,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
51 EBI-745305,EBI-77889 MAD2L2  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of cell-cell adhesion mediated by cadherin
.negative regulation of canonical Wnt signaling pathway
  + 19 more...
.JUN kinase binding
.RNA polymerase II activating transcription factor binding
.zeta DNA polymerase complex
.spindle
.cytoplasm
  + 2 more...
52 EBI-745305,EBI-742802 FAM50B  
  .N/A .N/A .nucleus
53 EBI-745305,EBI-372521 LSM4  
  .activation of mitophagy in response to mitochondrial depolarization
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
  + 4 more...
.poly(A) RNA binding .small nuclear ribonucleoprotein complex
.cytosol
.U6 snRNP
.spliceosomal complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood49
bone13
bone marrow61
eye4
lung2
lymph45
lymph node44
spleen93
stomach10
testis6
thymus50
trachea19
Health State
TissuesTPM*
normal18
chondrosarcoma12
gastrointestinal tumor8
germ cell tumor34
head and neck tumor7
leukemia52
lymphoma96
ovarian tumor13
prostate cancer9
Developmental Stage
TissuesTPM*
adult7
fetus26
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.2
adrenal gland2.4
appendix46
bone marrow133.2
cerebral cortex2.1
colon6.3
duodenum5
esophagus7
gallbladder19.5
heart muscle1.2
kidney1
liver3
lung10.7
lymph node87.1
ovary1.3
pancreas2.3
placenta3.3
prostate2
salivary gland3.2
skin1.5
small intestine10
spleen40.6
stomach10.7
testis2
thyroid gland2.1
urinary bladder15.2
Tissues
TissuesExpression level
appendixLow
bone marrowMedium
lymph nodeMedium
spleenMedium
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603023, gene) Ikaros family zinc finger 1; IKZF1OMIM
2acute lymphocytic leukemia;diffuse large B-cell lymphomaCGP


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