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> Protein (NX_Q13427)
Protein (NX_Q13427)
Protein
Gene SymbolPPIG to neXtProt (NX_Q13427)
DescriptionPeptidyl-prolyl cis-trans isomerase G
Chromosome2
Location2q31.1 (170440850 ~ 170497916) to Ensembl
Sequene Features : Isoforms 2, Variants 115, PTMs 24 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA splicing
.protein folding
.protein peptidyl-prolyl isomerization
.poly(A) RNA binding
.cyclosporin A binding
.peptidyl-prolyl cis-trans isomerase activity
.nuclear speck
.nuclear matrix
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 115 24
2014-09-19protein level
2 88 24
2014-05-27protein level
2 88 24
2014-02-25protein level
2 86 24
2013-12-09protein level
2 67 24
2013-11-01protein level
2 64 24
2013-09-12protein level
2 64 26
2013-08-17protein level
2 64 26
2013-07-15protein level
2 44 30
2013-06-11protein level
2 44 30
2013-02-12protein level
2 16 43
2012-12-20protein level
2 18 43
2012-10-30protein level
2 25 43
2012-10-07protein level
2 25 32
2012-08-24protein level
2 25 32
2012-07-28protein level
2 24 32
2012-06-08protein level
2 25 32
2012-05-07protein level
2 18 32
2012-04-10protein level
2 18 32
2012-01-13protein level
2 12 32
2011-12-20protein level
2 12 32
2011-11-11protein level
2 12 30
2011-08-23protein level
2 12 30
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13427-1
7 12 0 88563.8557
NX_Q13427-2
1 12 0 40274.3856
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-396072,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
2 EBI-396072,EBI-1170392 LGALS3  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
.negative regulation of immunological synapse formation
  + 19 more...
.poly(A) RNA binding
.laminin binding
.chemoattractant activity
  + 2 more...
.extracellular exosome
.membrane
.external side of plasma membrane
  + 8 more...
3 EBI-396072,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
4 EBI-396072,EBI-395290 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
5 EBI-396072,EBI-946095 PCBP1  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
.extracellular exosome
.intracellular membrane-bounded organelle
.ribonucleoprotein complex
  + 3 more...
6 EBI-396072,EBI-395421 SMN2  
  .ncRNA metabolic process
.gene expression
.nervous system development
  + 2 more...
.identical protein binding
.RNA binding
.Gemini of coiled bodies
.SMN-Sm protein complex
.SMN complex
  + 7 more...
7 EBI-396072,EBI-10181188 BEND7  
  .N/A .N/A .extracellular exosome
8 EBI-396072,EBI-2511344 KCTD6  
  .protein homooligomerization .ankyrin binding .N/A
9 EBI-396072,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
10 EBI-396072,EBI-724333 PPCDC  
  .small molecule metabolic process
.pantothenate metabolic process
.coenzyme A biosynthetic process
  + 3 more...
.phosphopantothenoylcysteine decarboxylase activity .cytosol
11 EBI-396072,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
12 EBI-396072,EBI-10186082 DACH1  
  .negative regulation of DNA biosynthetic process
.negative regulation of cell proliferation involved in contact inhibition
.negative regulation of fibroblast proliferation
  + 7 more...
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
.intracellular membrane-bounded organelle
.cytoplasm
.nucleolus
  + 3 more...
13 EBI-396072,EBI-302355 PNMA2  
  .positive regulation of apoptotic process .N/A .nucleolus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites150
bladder100
blood57
bone41
bone marrow164
brain2
cervix41
connective tissue20
ear124
embryonic tissue9
esophagus49
eye23
heart111
intestine17
kidney23
larynx42
liver9
lung23
lymph node11
mammary gland85
mouth90
muscle9
ovary9
pancreas4
parathyroid242
pharynx147
pituitary gland121
placenta10
prostate10
salivary gland49
skin23
spleen37
stomach20
testis25
thymus50
thyroid64
umbilical cord72
uterus34
vascular38
Health State
TissuesTPM*
normal16
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma12
colorectal tumor26
esophageal tumor57
gastrointestinal tumor16
germ cell tumor15
glioma74
head and neck tumor7
kidney tumor29
leukemia137
liver tumor10
lung tumor9
lymphoma27
non-neoplasia20
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer48
retinoblastoma43
skin tumor31
soft tissue/muscle tissue tumor55
uterine tumor55
Developmental Stage
TissuesTPM*
adult11
embryoid body28
blastocyst81
neonate32
fetus34
infant85
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.1
adrenal gland30.2
appendix39.2
bone marrow42.1
cerebral cortex29.3
colon33.9
duodenum34
esophagus32.6
gallbladder34.5
heart muscle25.1
kidney32.4
liver33.8
lung29.8
lymph node48.6
ovary30.1
pancreas13.5
placenta33.9
prostate36.2
salivary gland22.8
skin27.8
small intestine35.7
spleen37.1
stomach32.4
testis29
thyroid gland39.7
urinary bladder37.6
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineMedium
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606093, gene) Peptidyl-prolyl isomerase g; PPIGOMIM


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