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> Protein (NX_Q13428)
Protein (NX_Q13428)
Protein
Gene SymbolTCOF1 to neXtProt (NX_Q13428)
DescriptionTreacle protein
Chromosome5
Location5q32 (149737202 ~ 149779871) to Ensembl
Sequene Features : Isoforms 8, Variants 167, PTMs 74 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.transcription of nuclear large rRNA transcript from RNA polymerase I promoter
.skeletal system development
.poly(A) RNA binding
.transporter activity
.cytoplasm
.nucleolus
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 167 74
2014-09-19protein level
8 146 74
2014-05-27protein level
8 146 74
2014-02-25protein level
8 146 69
2013-12-09protein level
8 112 69
2013-11-01protein level
8 108 68
2013-09-12protein level
8 108 95
2013-08-17protein level
8 108 95
2013-07-15protein level
8 85 95
2013-06-11protein level
8 85 95
2013-02-12protein level
8 61 916
2012-12-20protein level
8 56 916
2012-10-30protein level
8 66 916
2012-10-07protein level
8 66 120
2012-08-24protein level
8 63 120
2012-07-28protein level
8 63 120
2012-06-08protein level
8 65 120
2012-05-07protein level
8 61 120
2012-04-10protein level
8 61 120
2012-01-13protein level
8 38 120
2011-12-20protein level
8 38 120
2011-11-11protein level
8 38 117
2011-08-23protein level
8 38 116
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13428-1
0 65 0 152014.8801
NX_Q13428-2
0 62 0 144227.9027
NX_Q13428-3
0 65 0 152113.9482
NX_Q13428-4
3 64 0 155835.7044
NX_Q13428-5
1 41 0 96699.1776
NX_Q13428-6
0 62 0 148164.7489
NX_Q13428-7
0 62 0 148263.817
NX_Q13428-8
0 62 0 144326.9708
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-396105,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
2 EBI-396105,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites125
bladder66
blood40
bone83
bone marrow82
brain47
cervix61
connective tissue67
embryonic tissue98
esophagus198
eye90
heart11
intestine103
kidney33
larynx170
liver38
lung110
lymph22
lymph node100
mammary gland92
mouth90
muscle75
ovary167
pancreas14
parathyroid48
placenta74
prostate58
skin147
spleen37
stomach20
testis52
thymus50
thyroid42
trachea57
umbilical cord290
uterus30
vascular19
Health State
TissuesTPM*
normal38
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor128
cervical tumor57
chondrosarcoma108
colorectal tumor115
esophageal tumor231
gastrointestinal tumor126
germ cell tumor174
glioma9
head and neck tumor82
kidney tumor58
leukemia42
liver tumor62
lung tumor194
lymphoma13
non-neoplasia41
ovarian tumor210
pancreatic tumor28
primitive neuroectodermal tumor of the CNS78
prostate cancer77
retinoblastoma236
skin tumor247
soft tissue/muscle tissue tumor63
uterine tumor22
Developmental Stage
TissuesTPM*
adult69
embryoid body114
blastocyst146
neonate64
fetus41
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.9
adrenal gland7.4
appendix15
bone marrow10.5
cerebral cortex7.4
colon9.1
duodenum7
esophagus8.9
gallbladder7.7
heart muscle6.5
kidney6.6
liver3.2
lung9.5
lymph node19.2
ovary11.2
pancreas5.6
placenta10.1
prostate9.7
salivary gland8.2
skin12
small intestine7.5
spleen15.3
stomach8.2
testis12.6
thyroid gland8.4
urinary bladder9.3
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#154500, phenotype) Treacher collins syndrome 1; TCS1OMIM
2(*606847, gene) Tcof1 gene; TCOF1OMIM


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