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> Protein (NX_Q13443)
Protein (NX_Q13443)
Protein
Gene SymbolADAM9 to neXtProt (NX_Q13443)
DescriptionDisintegrin and metalloproteinase domain-containing protein 9
Chromosome8
Location8p11.22 (38854388 ~ 38962663) to Ensembl
Sequene Features : Isoforms 2, Variants 74, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to lipopolysaccharide
.response to calcium ion
.positive regulation of keratinocyte migration
  + 23 more...
.laminin binding
.SH3 domain binding
.zinc ion binding
  + 5 more...
.extracellular exosome
.intrinsic component of external side of plasma membrane
.basolateral plasma membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 74 16
2014-09-19protein level
2 57 16
2014-05-27protein level
2 57 16
2014-02-25protein level
2 57 15
2013-12-09protein level
2 49 15
2013-11-01protein level
2 44 15
2013-09-12protein level
2 44 15
2013-08-17protein level
2 44 15
2013-07-15protein level
2 30 15
2013-06-11protein level
2 30 15
2013-02-12protein level
2 15 26
2012-12-20protein level
2 13 26
2012-10-30protein level
2 15 26
2012-10-07protein level
2 15 16
2012-08-24protein level
2 15 16
2012-07-28protein level
2 15 16
2012-06-08protein level
2 24 16
2012-05-07protein level
2 16 16
2012-04-10protein level
2 16 16
2012-01-13protein level
2 12 16
2011-12-20protein level
2 12 16
2011-11-11protein level
2 12 16
2011-08-23protein level
2 12 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13443-1
10 30 0 90496.8687
NX_Q13443-2
0 30 0 72311.7223
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-77903,EBI-77938 SH3GL2  
  .membrane organization
.synaptic vesicle endocytosis
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.identical protein binding
.lipid binding
.extracellular exosome
.clathrin-coated endocytic vesicle membrane
.plasma membrane
  + 2 more...
2 EBI-77903,EBI-77889 MAD2L2  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of cell-cell adhesion mediated by cadherin
.negative regulation of canonical Wnt signaling pathway
  + 19 more...
.JUN kinase binding
.RNA polymerase II activating transcription factor binding
.zeta DNA polymerase complex
.spindle
.cytoplasm
  + 2 more...
3 EBI-77903,EBI-77926 PACSIN3  
  .membrane tubulation
.negative regulation of calcium ion transport
.positive regulation of membrane protein ectodomain proteolysis
  + 4 more...
.calcium channel inhibitor activity
.lipid binding
.cytoskeletal protein binding
.phospholipid binding
.extracellular exosome
.membrane-bounded vesicle
.membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites75
bladder133
blood32
bone125
bone marrow20
brain21
cervix41
connective tissue120
embryonic tissue56
esophagus99
eye23
heart44
intestine77
kidney56
larynx127
liver34
lung68
lymph node11
mammary gland138
mouth30
muscle37
nerve128
ovary29
pancreas60
placenta38
prostate184
skin56
stomach209
testis27
thyroid64
umbilical cord72
uterus21
vascular271
Health State
TissuesTPM*
normal41
bladder carcinoma113
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma132
colorectal tumor106
esophageal tumor115
gastrointestinal tumor210
germ cell tumor30
glioma37
head and neck tumor59
kidney tumor87
leukemia42
liver tumor62
lung tumor48
non-neoplasia20
ovarian tumor65
pancreatic tumor66
primitive neuroectodermal tumor of the CNS62
prostate cancer269
skin tumor39
soft tissue/muscle tissue tumor87
uterine tumor44
Developmental Stage
TissuesTPM*
adult86
embryoid body157
neonate32
fetus16
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue40.3
adrenal gland34.6
appendix50.2
bone marrow30.2
cerebral cortex28.3
colon48.5
duodenum37.5
esophagus37.7
gallbladder73.5
heart muscle32.4
kidney44.2
liver11.1
lung54.7
lymph node18
ovary20.4
pancreas8.3
placenta56
prostate51.1
salivary gland18.1
skin14.6
small intestine37
spleen35.1
stomach66.1
testis25.5
thyroid gland50.3
urinary bladder68.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602713, gene) A disintegrin and metalloproteinase domain 9; ADAM9OMIM
2(#612775, phenotype) Cone-rod dystrophy 9; CORD9OMIM


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