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> Protein (NX_Q13444)
Protein (NX_Q13444)
Protein
Gene SymbolADAM15 to neXtProt (NX_Q13444)
DescriptionDisintegrin and metalloproteinase domain-containing protein 15
Chromosome1
Location1q22 (155023042 ~ 155035252) to Ensembl
Sequene Features : Isoforms 13, Variants 135, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of receptor binding
.protein kinase C signaling
.cardiac epithelial to mesenchymal transition
  + 11 more...
.SH3 domain binding
.zinc ion binding
.metallopeptidase activity
  + 2 more...
.extracellular exosome
.cell projection
.integral component of membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
13 135 15
2014-09-19protein level
13 114 15
2014-05-27protein level
12 107 15
2014-02-25protein level
12 107 15
2013-12-09protein level
12 84 15
2013-11-01protein level
12 76 15
2013-09-12protein level
12 76 15
2013-08-17protein level
12 80 15
2013-07-15protein level
12 58 15
2013-06-11protein level
12 58 15
2013-02-12protein level
12 38 152
2012-12-20protein level
12 41 152
2012-10-30protein level
11 44 139
2012-10-07protein level
11 44 14
2012-08-24protein level
11 41 14
2012-07-28protein level
11 41 14
2012-06-08protein level
11 46 14
2012-05-07protein level
11 38 14
2012-04-10protein level
11 38 14
2012-01-13protein level
11 25 14
2011-12-20protein level
11 25 14
2011-11-11protein level
11 25 14
2011-08-23protein level
11 25 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13444-1
0 37 0 92898.9279
NX_Q13444-10
1 33 0 83609.7451
NX_Q13444-11
1 21 0 55408.8476
NX_Q13444-12
1 34 0 88666.6476
NX_Q13444-13
3 22 0 68211.0885
NX_Q13444-2
0 35 0 87687.1013
NX_Q13444-3
0 37 0 92770.8697
NX_Q13444-4
1 35 0 90324.5326
NX_Q13444-5
0 36 0 90261.4966
NX_Q13444-6
0 34 0 88721.6626
NX_Q13444-7
0 34 0 88593.6044
NX_Q13444-8
0 33 0 86084.2313
NX_Q13444-9
1 33 0 86254.1899
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-77818,EBI-953828 NPHP1  
  .retina development in camera-type eye
.spermatid differentiation
.photoreceptor cell outer segment organization
  + 8 more...
.structural molecule activity .ciliary base
.ciliary transition zone
.photoreceptor connecting cilium
  + 7 more...
2 EBI-77818,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
3 EBI-77818,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
4 EBI-77818,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
5 EBI-77818,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
6 EBI-77818,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
7 EBI-77818,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
8 EBI-77818,EBI-10198587 SP4  
  .regulation of heart contraction
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription coactivator activity
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.intercellular bridge
.microtubule cytoskeleton
.cytoplasm
.nucleoplasm
9 EBI-77818,EBI-741101 FHL3  
  .actin cytoskeleton organization
.muscle organ development
.zinc ion binding .Z disc
.focal adhesion
.nucleus
.stress fiber
10 EBI-77818,EBI-2483234 SH3PXD2A  
  .osteoclast fusion
.superoxide metabolic process
.phosphatidylinositol binding .cell projection
.cell junction
.cytoplasm
.podosome
11 EBI-77818,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
12 EBI-77818,EBI-2481535 SNX33  
  .positive regulation of protein localization to cell surface
.negative regulation of protein localization to cell surface
.membrane tubulation
  + 12 more...
.identical protein binding
.phosphatidylinositol binding
.cytoplasmic vesicle membrane
.extrinsic component of membrane
.cytoplasmic membrane-bounded vesicle
  + 3 more...
13 EBI-77818,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
14 EBI-77818,EBI-77938 SH3GL2  
  .membrane organization
.synaptic vesicle endocytosis
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.identical protein binding
.lipid binding
.extracellular exosome
.clathrin-coated endocytic vesicle membrane
.plasma membrane
  + 2 more...
15 EBI-77818,EBI-77926 PACSIN3  
  .membrane tubulation
.negative regulation of calcium ion transport
.positive regulation of membrane protein ectodomain proteolysis
  + 4 more...
.calcium channel inhibitor activity
.lipid binding
.cytoskeletal protein binding
.phospholipid binding
.extracellular exosome
.membrane-bounded vesicle
.membrane
  + 4 more...
16 EBI-77818,EBI-77848 SNX9  
  .membrane tubulation
.lipid tube assembly
.positive regulation of membrane protein ectodomain proteolysis
  + 11 more...
.Arp2/3 complex binding
.protein homodimerization activity
.phosphatidylinositol binding
  + 2 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic vesicle membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites326
bladder66
blood73
bone97
bone marrow102
brain128
cervix433
connective tissue87
embryonic tissue37
esophagus99
eye81
heart67
intestine155
kidney170
larynx42
liver34
lung122
mammary gland138
mouth529
muscle28
nerve193
ovary78
pancreas210
placenta134
prostate163
skin137
spleen149
stomach94
testis45
thymus138
thyroid343
trachea193
umbilical cord363
uterus73
vascular425
Health State
TissuesTPM*
normal100
bladder carcinoma113
breast (mammary gland) tumor161
cervical tumor463
chondrosarcoma60
colorectal tumor115
esophageal tumor115
gastrointestinal tumor160
germ cell tumor132
glioma233
head and neck tumor328
kidney tumor130
leukemia158
liver tumor62
lung tumor194
lymphoma152
non-neoplasia155
ovarian tumor78
pancreatic tumor361
primitive neuroectodermal tumor of the CNS157
prostate cancer192
retinoblastoma43
skin tumor63
uterine tumor55
Developmental Stage
TissuesTPM*
adult103
embryoid body28
blastocyst16
neonate547
fetus50
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue72.3
adrenal gland16.7
appendix32.7
bone marrow60.8
cerebral cortex17.5
colon47.9
duodenum35.9
esophagus80.7
gallbladder49
heart muscle45
kidney14.3
liver8.7
lung58.3
lymph node22
ovary22.8
pancreas16
placenta37.9
prostate44.2
salivary gland39.1
skin118.5
small intestine31.8
spleen52.7
stomach53.9
testis14
thyroid gland27.6
urinary bladder38
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605548, gene) A disintegrin and metalloproteinase domain 15; ADAM15OMIM


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