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> Protein (NX_Q13464)
Protein (NX_Q13464)
Protein
Gene SymbolROCK1 to neXtProt (NX_Q13464)
DescriptionRho-associated protein kinase 1
Chromosome18
Location18q11.1 (18526867 ~ 18691812) to Ensembl
Sequene Features : Isoforms 1, Variants 147, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell motility
.regulation of establishment of cell polarity
.positive regulation of focal adhesion assembly
  + 27 more...
.metal ion binding
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.bleb
.lamellipodium
.plasma membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 147 6
2014-09-19protein level
1 108 6
2014-05-27protein level
1 108 6
2014-02-25protein level
1 102 6
2013-12-09protein level
1 103 6
2013-11-01protein level
1 95 6
2013-09-12protein level
1 95 6
2013-08-17protein level
1 95 6
2013-07-15protein level
1 62 6
2013-06-11protein level
1 62 6
2013-02-12protein level
1 28 6
2012-12-20protein level
1 28 6
2012-10-30protein level
1 29 6
2012-10-07protein level
1 29 6
2012-08-24protein level
1 18 6
2012-07-28protein level
1 18 6
2012-06-08protein level
1 26 6
2012-05-07protein level
1 26 6
2012-04-10protein level
1 26 6
2012-01-13protein level
1 24 6
2011-12-20protein level
1 24 6
2011-11-11protein level
1 24 6
2011-08-23protein level
1 24 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13464-1
63 0 9 158075.2909
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-876651,EBI-751857 MAGEB4  
  .N/A .N/A .N/A
2 EBI-876651,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
3 EBI-876651,EBI-446668 RHOA  
  .skeletal muscle satellite cell migration
.mitotic spindle assembly
.trabecula morphogenesis
  + 32 more...
.myosin binding
.GTP binding
.GTPase activity
.extracellular exosome
.apical junction complex
.cleavage furrow
  + 11 more...
4 EBI-876651,EBI-5655165 MYBPH  
  .cell adhesion
.regulation of striated muscle contraction
.structural constituent of muscle .myosin filament
5 EBI-876651,EBI-744506 FAM124A  
  .N/A .N/A .N/A
6 EBI-876651,EBI-749051 C6orf165  
  .N/A .N/A .N/A
7 EBI-876651,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
8 EBI-876651,EBI-5452779 POLR3C  
  .defense response to virus
.positive regulation of innate immune response
.innate immune response
  + 7 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase III complex
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
bladder100
blood49
bone55
bone marrow82
brain41
cervix41
connective tissue26
ear124
embryonic tissue108
eye57
heart33
intestine64
kidney52
larynx42
liver58
lung50
lymph22
lymph node144
mammary gland79
mouth75
muscle84
nerve128
ovary9
pancreas51
parathyroid48
pharynx24
placenta60
prostate47
skin52
spleen37
stomach10
testis41
thymus37
thyroid64
trachea96
uterus47
vascular77
Health State
TissuesTPM*
normal59
bladder carcinoma56
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma24
colorectal tumor53
gastrointestinal tumor33
germ cell tumor106
glioma18
head and neck tumor52
kidney tumor14
leukemia63
liver tumor114
lymphoma41
non-neoplasia31
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer48
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor31
uterine tumor55
Developmental Stage
TissuesTPM*
adult59
embryoid body100
blastocyst81
neonate96
fetus53
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.5
adrenal gland14.4
appendix24.5
bone marrow53.3
cerebral cortex6.5
colon13.8
duodenum10.6
esophagus19.9
gallbladder18.7
heart muscle10.9
kidney11.6
liver9.8
lung17.6
lymph node23.7
ovary15.1
pancreas4.7
placenta14.9
prostate16.8
salivary gland6.3
skin8
small intestine13.2
spleen20.9
stomach14.4
testis11
thyroid gland12.7
urinary bladder21
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601702, gene) Rho-associated coiled-coil-containing protein kinase 1; ROCK1OMIM


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