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> Protein (NX_Q13480)
Protein (NX_Q13480)
Protein
Gene SymbolGAB1 to neXtProt (NX_Q13480)
DescriptionGRB2-associated-binding protein 1
Chromosome4
Location4q31.21 (144257915 ~ 144395721) to Ensembl
Sequene Features : Isoforms 2, Variants 75, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 75 6
2014-09-19protein level
2 64 6
2014-05-27protein level
2 64 6
2014-02-25protein level
2 61 5
2013-12-09protein level
2 53 5
2013-11-01protein level
2 48 5
2013-09-12protein level
2 48 6
2013-08-17protein level
2 48 6
2013-07-15protein level
2 33 6
2013-06-11protein level
2 33 6
2013-02-12protein level
2 14 17
2012-12-20protein level
2 15 17
2012-10-30protein level
2 15 17
2012-10-07protein level
2 15 9
2012-08-24protein level
2 14 9
2012-07-28protein level
2 14 9
2012-06-08protein level
2 16 9
2012-05-07protein level
2 10 9
2012-04-10protein level
2 10 9
2012-01-13protein level
2 9 9
2011-12-20protein level
2 9 9
2011-11-11protein level
2 9 9
2011-08-23protein level
2 9 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13480-1
0 29 0 76568.2936
NX_Q13480-2
2 29 0 79955.1479
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-517684,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
2 EBI-517684,EBI-714146 SOCS3  
  .spongiotrophoblast differentiation
.trophoblast giant cell differentiation
.placenta blood vessel development
  + 16 more...
.protein kinase inhibitor activity .cytosol
.cytoplasm
3 EBI-517684,EBI-3929549 SOCS6  
  .negative regulation of T cell activation
.negative regulation of JAK-STAT cascade
.regulation of growth
  + 6 more...
.protein kinase inhibitor activity .cytoplasm
.immunological synapse
4 EBI-517684,EBI-3923013 SH2D1B  
  .positive regulation of innate immune response
.positive regulation of natural killer cell mediated immunity
.leukocyte activation involved in immune response
.protein binding, bridging .intracellular
5 EBI-517684,EBI-1384248 INPPL1  
  .ruffle assembly
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
  + 13 more...
.SH2 domain binding
.hydrolase activity
.filopodium
.lamellipodium
.plasma membrane
  + 4 more...
6 EBI-517684,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
7 EBI-517684,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
8 EBI-517684,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
9 EBI-517684,EBI-1055635 FES  
  .positive regulation of actin cytoskeleton reorganization
.regulation of cell motility
.regulation of vesicle-mediated transport
  + 19 more...
.phosphatidylinositol binding
.immunoglobulin receptor binding
.ATP binding
  + 2 more...
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic membrane-bounded vesicle
.microtubule cytoskeleton
  + 4 more...
10 EBI-517684,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
11 EBI-517684,EBI-79452 LYN  
  .positive regulation of dendritic cell apoptotic process
.negative regulation of intracellular signal transduction
.dendritic cell differentiation
  + 83 more...
.ion channel binding
.glycosphingolipid binding
.enzyme binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 11 more...
12 EBI-517684,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
13 EBI-517684,EBI-625518 VAV1  
  .apoptotic signaling pathway
.reactive oxygen species metabolic process
.regulation of small GTPase mediated signal transduction
  + 19 more...
.metal ion binding
.Rac guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.sequence-specific DNA binding transcription factor activity
.cell-cell junction
.plasma membrane
.cytosol
14 EBI-517684,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
15 EBI-517684,EBI-617403 PLCG2  
  .release of sequestered calcium ion into cytosol
.B cell receptor signaling pathway
.T cell receptor signaling pathway
  + 19 more...
.signal transducer activity
.phospholipase C activity
.phosphatidylinositol phospholipase C activity
.extracellular exosome
.plasma membrane
.cytosol
16 EBI-517684,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
17 EBI-517684,EBI-1026476 RASA1  
  .regulation of RNA metabolic process
.blood vessel morphogenesis
.ephrin receptor signaling pathway
  + 14 more...
.GTPase binding
.potassium channel inhibitor activity
.receptor binding
  + 2 more...
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
.cytoplasm
.ruffle
18 EBI-517684,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
19 EBI-517684,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
20 EBI-517684,EBI-1383480 TEC  
  .B cell receptor signaling pathway
.T cell receptor signaling pathway
.positive regulation of peptidyl-tyrosine phosphorylation
  + 12 more...
.metal ion binding
.phospholipid binding
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cell-cell junction
.cytoskeleton
.cytosol
21 EBI-517684,EBI-78302 SYK  
  .regulation of platelet aggregation
.regulation of arachidonic acid secretion
.cellular response to molecule of fungal origin
  + 49 more...
.ATP binding
.integrin binding
.receptor signaling protein tyrosine kinase activity
  + 4 more...
.protein complex
.T cell receptor complex
.early phagosome
  + 6 more...
22 EBI-517684,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
23 EBI-517684,EBI-910 CRKL  
  .parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
24 EBI-517684,EBI-702209 PXN  
  .growth hormone receptor signaling pathway
.branching morphogenesis of an epithelial tube
.focal adhesion assembly
  + 16 more...
.vinculin binding
.zinc ion binding
.beta-catenin binding
.lamellipodium
.cell cortex
.focal adhesion
  + 6 more...
25 EBI-517684,EBI-2105445 BLK  
  .cellular response to peptide hormone stimulus
.B cell receptor signaling pathway
.innate immune response
  + 6 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
26 EBI-517684,EBI-297549 VAV2  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.ephrin receptor signaling pathway
  + 17 more...
.metal ion binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.plasma membrane
.cytosol
27 EBI-517684,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
28 EBI-517684,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
29 EBI-517684,EBI-2264500 PTPRJ  
  .negative regulation of receptor activity
.contact inhibition
.negative regulation of protein kinase B signaling
  + 21 more...
.delta-catenin binding
.mitogen-activated protein kinase binding
.gamma-catenin binding
  + 5 more...
.extracellular exosome
.ruffle membrane
.cell junction
  + 6 more...
30 EBI-517684,EBI-1383632 PTK6  
  .cellular response to retinoic acid
.negative regulation of protein tyrosine kinase activity
.intestinal epithelial cell differentiation
  + 12 more...
.identical protein binding
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleoplasm
  + 2 more...
31 EBI-517684,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
32 EBI-517684,EBI-1222854 SLA2  
  .negative regulation of B cell activation
.antigen receptor-mediated signaling pathway
.negative regulation of calcium-mediated signaling
  + 6 more...
.protein N-terminus binding
.SH3/SH2 adaptor activity
.cytoplasmic membrane-bounded vesicle
.endosome membrane
.plasma membrane
  + 2 more...
33 EBI-517684,EBI-490630 SH2D2A  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .cytosol
.cytoplasm
34 EBI-517684,EBI-297568 VAV3  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.B cell receptor signaling pathway
  + 22 more...
.metal ion binding
.Rac guanyl-nucleotide exchange factor activity
.GTPase activator activity
  + 2 more...
.extracellular exosome
.plasma membrane
.cytosol
35 EBI-517684,EBI-6083058 STAP1  
  .positive regulation of actin cytoskeleton reorganization
.positive regulation of non-membrane spanning protein tyrosine kinase activity
.positive regulation of microglial cell activation
  + 10 more...
.protein kinase binding
.phospholipid binding
.SH3/SH2 adaptor activity
  + 2 more...
.protein complex
.mitochondrion
.cytoplasm
.nucleus
36 EBI-517684,EBI-10229384 GTF2A1L  
  .cognition
.transcription initiation from RNA polymerase II promoter
.transcription from RNA polymerase II promoter
.regulation of transcription, DNA-templated
.transcription coactivator activity
.DNA binding
.cytoplasm
.transcription factor TFIIA complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bone27
bone marrow41
brain72
connective tissue26
ear62
embryonic tissue23
esophagus99
eye62
heart44
intestine8
kidney23
liver14
lung8
lymph22
lymph node11
mammary gland26
mouth60
muscle18
nerve64
pharynx24
pituitary gland121
placenta45
prostate42
skin14
testis20
thymus12
thyroid21
trachea19
uterus56
vascular38
Health State
TissuesTPM*
normal57
adrenal tumor79
breast (mammary gland) tumor21
chondrosarcoma12
colorectal tumor8
esophageal tumor115
germ cell tumor37
glioma46
head and neck tumor29
leukemia10
liver tumor10
lymphoma13
non-neoplasia20
prostate cancer19
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult40
blastocyst48
fetus91
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.9
adrenal gland9.8
appendix8.5
bone marrow15.8
cerebral cortex22
colon22.1
duodenum12.6
esophagus22
gallbladder15.5
heart muscle27
kidney14.1
liver5.9
lung21.7
lymph node7.5
ovary20
pancreas3.9
placenta26
prostate7.9
salivary gland5.7
skin11
small intestine14
spleen8
stomach11.1
testis11.1
thyroid gland9.3
urinary bladder10.6
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*604439, gene) Grb2-associated binding protein 1; GAB1OMIM


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