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> Protein (NX_Q13485)
Protein (NX_Q13485)
Protein
Gene SymbolSMAD4 to neXtProt (NX_Q13485)
DescriptionMothers against decapentaplegic homolog 4
Chromosome18
Location18q21.2 (48494410 ~ 48611415) to Ensembl
Sequene Features : Isoforms 1, Variants 290, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nephrogenic mesenchyme morphogenesis
.metanephric mesenchyme morphogenesis
.response to transforming growth factor beta
  + 49 more...
.R-SMAD binding
.I-SMAD binding
.metal ion binding
  + 9 more...
.SMAD protein complex
.activin responsive factor complex
.cytosol
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 290 5
2014-09-19protein level
1 261 5
2014-05-27protein level
1 259 5
2014-02-25protein level
1 260 5
2013-12-09protein level
1 255 5
2013-11-01protein level
1 253 5
2013-09-12protein level
1 253 5
2013-08-17protein level
1 253 5
2013-07-15protein level
1 176 4
2013-06-11protein level
1 176 4
2013-02-12protein level
1 124 4
2012-12-20protein level
1 124 4
2012-10-30protein level
1 124 4
2012-10-07protein level
1 124 4
2012-08-24protein level
1 123 4
2012-07-28protein level
1 123 4
2012-06-08protein level
1 22 4
2012-05-07protein level
1 19 4
2012-04-10protein level
1 19 4
2012-01-13protein level
1 18 4
2011-12-20protein level
1 17 4
2011-11-11protein level
1 17 4
2011-08-23protein level
1 17 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13485-1
20 0 0 60400.7093
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347263,EBI-1644164 FOXO3  
  .regulation of reactive oxygen species metabolic process
.regulation of neural precursor cell proliferation
.extrinsic apoptotic signaling pathway in absence of ligand
  + 24 more...
.sequence-specific DNA binding
.chromatin DNA binding
.protein kinase binding
  + 5 more...
.membrane
.cytosol
.cytoplasm
  + 2 more...
2 EBI-347263,EBI-298336 SP1  
  .definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 19 more...
.HMG box domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 16 more...
.protein-DNA complex
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-347263,EBI-347281 SKI  
  .protein homotrimerization
.SMAD protein signal transduction
.bone morphogenesis
  + 34 more...
.repressing transcription factor binding
.histone deacetylase inhibitor activity
.SMAD binding
  + 6 more...
.protein complex
.transcriptional repressor complex
.PML body
  + 6 more...
4 EBI-347263,EBI-2806671 GATA2  
  .regulation of forebrain neuron differentiation
.negative regulation of neural precursor cell proliferation
.GABAergic neuron differentiation
  + 29 more...
.C2H2 zinc finger domain binding
.zinc ion binding
.transcription factor binding
  + 5 more...
.protein complex
.nucleoplasm
5 EBI-347263,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
6 EBI-347263,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
7 EBI-347263,EBI-80168 UBE2I  
  .positive regulation of SUMO transferase activity
.cell division
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 14 more...
.RING-like zinc finger domain binding
.SUMO conjugating enzyme activity
.poly(A) RNA binding
  + 6 more...
.sumoylated E2 ligase complex
.transferase complex
.synapse
  + 7 more...
8 EBI-347263,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
9 EBI-347263,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
10 EBI-347263,EBI-1567153 SMAD1  
  .positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
.cellular response to BMP stimulus
.positive regulation of cartilage development
  + 28 more...
.I-SMAD binding
.co-SMAD binding
.metal ion binding
  + 8 more...
.protein complex
.integral component of membrane
.cytosol
  + 6 more...
11 EBI-347263,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
12 EBI-347263,EBI-1752755 DLX4  
  .multicellular organismal development
.regulation of transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
13 EBI-347263,EBI-302524 USP9X  
  .regulation of proteasomal protein catabolic process
.cell division
.axon extension
  + 16 more...
.co-SMAD binding
.cysteine-type peptidase activity
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.apical part of cell
.growth cone
.membrane
  + 2 more...
14 EBI-347263,EBI-366978 NLK  
  .protein autophosphorylation
.intracellular signal transduction
.serine phosphorylation of STAT3 protein
  + 8 more...
.SH2 domain binding
.ubiquitin protein ligase binding
.transcription factor binding
  + 5 more...
.cytosol
.nucleoplasm
.nucleus
15 EBI-347263,EBI-347111 DACH1  
  .negative regulation of DNA biosynthetic process
.negative regulation of cell proliferation involved in contact inhibition
.negative regulation of fibroblast proliferation
  + 7 more...
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
.intracellular membrane-bounded organelle
.cytoplasm
.nucleolus
  + 3 more...
16 EBI-347263,EBI-2214398 TRIM33  
  .negative regulation of transcription, DNA-templated
.negative regulation of BMP signaling pathway
.regulation of transforming growth factor beta receptor signaling pathway
  + 6 more...
.R-SMAD binding
.co-SMAD binding
.ligase activity
  + 3 more...
.intracellular membrane-bounded organelle
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder100
blood32
bone27
bone marrow20
brain57
cervix41
connective tissue33
ear310
embryonic tissue117
eye38
heart55
intestine34
kidney94
liver58
lung71
lymph45
lymph node44
mammary gland99
mouth75
muscle131
nerve128
ovary98
pancreas18
parathyroid194
pharynx73
pituitary gland121
placenta63
prostate121
salivary gland49
skin23
spleen74
stomach41
testis66
thymus112
thyroid236
tonsil58
trachea115
uterus68
vascular38
Health State
TissuesTPM*
normal71
adrenal tumor79
breast (mammary gland) tumor107
cervical tumor57
chondrosarcoma60
colorectal tumor26
gastrointestinal tumor16
germ cell tumor68
glioma9
head and neck tumor134
kidney tumor58
leukemia42
liver tumor62
lung tumor58
lymphoma27
non-neoplasia20
ovarian tumor91
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer192
skin tumor23
soft tissue/muscle tissue tumor95
uterine tumor44
Developmental Stage
TissuesTPM*
adult72
embryoid body128
blastocyst48
neonate32
fetus104
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue37.9
adrenal gland36.3
appendix39.7
bone marrow16.6
cerebral cortex27.8
colon35
duodenum39.9
esophagus44.2
gallbladder41.2
heart muscle38.1
kidney40.6
liver25.4
lung37.8
lymph node33.1
ovary65.6
pancreas25.1
placenta52.9
prostate53.9
salivary gland25.8
skin21.6
small intestine36.6
spleen33.3
stomach39.8
testis49.1
thyroid gland64
urinary bladder45.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#114500, phenotype) Colorectal cancer; CRCOMIM
2(#139210, phenotype) Myhre syndrome; MYHRSOMIM
3(#174900, phenotype) Juvenile polyposis syndrome; JPSOMIM
4(#175050, phenotype) Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome;OMIM
5(#260350, phenotype) Pancreatic cancerOMIM
6(*600993, gene) Mothers against decapentaplegic, drosophila, homolog of, 4; SMAD4OMIM


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