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> Protein (NX_Q13489)
Protein (NX_Q13489)
Protein
Gene SymbolBIRC3 to neXtProt (NX_Q13489)
DescriptionBaculoviral IAP repeat-containing protein 3
Chromosome11
Location11q22.2 (102188215 ~ 102210134) to Ensembl
Sequene Features : Isoforms 1, Variants 71, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of reactive oxygen species metabolic process
.regulation of cysteine-type endopeptidase activity
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
  + 27 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.membrane raft
.protein complex
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 71 0
2014-09-19protein level
1 50 0
2014-05-27protein level
1 50 1
2014-02-25protein level
1 50 1
2013-12-09protein level
1 38 1
2013-11-01protein level
1 35 1
2013-09-12protein level
1 35 1
2013-08-17protein level
1 35 1
2013-07-15protein level
1 23 0
2013-06-11protein level
1 23 0
2013-02-12protein level
1 11 0
2012-12-20protein level
1 11 0
2012-10-30protein level
1 12 0
2012-10-07protein level
1 12 0
2012-08-24protein level
1 12 0
2012-07-28protein level
1 12 0
2012-06-08protein level
1 21 0
2012-05-07protein level
1 14 0
2012-04-10protein level
1 14 0
2012-01-13protein level
1 13 0
2011-12-20protein level
1 13 0
2011-11-11protein level
1 13 0
2011-08-23protein level
1 13 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13489-1
23 0 7 68327.4497
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-517709,EBI-358522 RIPK2  
  .cellular response to muramyl dipeptide
.cellular response to peptidoglycan
.cellular response to lipoteichoic acid
  + 57 more...
.CARD domain binding
.protein homodimerization activity
.LIM domain binding
  + 4 more...
.protein complex
.vesicle
.cytoskeleton
  + 2 more...
2 EBI-517709,EBI-516799 CASP9  
  .regulation of response to DNA damage stimulus
.intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
  + 23 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.protein kinase binding
.SH3 domain binding
  + 3 more...
.apoptosome
.cytosol
.mitochondrion
.nucleus
3 EBI-517709,EBI-4422308 RIPK4  
  .positive regulation of NF-kappaB transcription factor activity
.morphogenesis of an epithelium
.ATP binding
.protein serine/threonine kinase activity
.membrane
.cytoplasm
.nucleus
4 EBI-517709,EBI-1052908 UBE2N  
  .protein K63-linked ubiquitination
.nucleotide-binding oligomerization domain containing signaling pathway
.positive regulation of ubiquitin-protein transferase activity
  + 29 more...
.ubiquitin protein ligase activity
.poly(A) RNA binding
.ubiquitin binding
  + 5 more...
.extracellular exosome
.protein complex
.UBC13-UEV1A complex
  + 5 more...
5 EBI-517709,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
6 EBI-517709,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
7 EBI-517709,EBI-358507 RIPK1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 48 more...
.death domain binding
.identical protein binding
.protein complex binding
  + 5 more...
.ripoptosome
.membrane raft
.receptor complex
  + 4 more...
8 EBI-517709,EBI-298250 RIPK3  
  .positive regulation of intrinsic apoptotic signaling pathway
.regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
.positive regulation of reactive oxygen species metabolic process
  + 35 more...
.identical protein binding
.protein complex binding
.ATP binding
  + 4 more...
.ripoptosome
.plasma membrane
.cytosol
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
blood89
bone13
brain3
connective tissue40
esophagus49
eye4
intestine99
kidney80
liver34
lung29
lymph90
lymph node311
mammary gland46
mouth15
muscle28
nerve128
ovary9
pancreas18
prostate5
skin23
thymus25
thyroid42
trachea38
uterus38
vascular58
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor32
chondrosarcoma48
colorectal tumor159
esophageal tumor57
germ cell tumor18
glioma18
head and neck tumor14
kidney tumor14
leukemia52
liver tumor52
lymphoma110
non-neoplasia31
pancreatic tumor19
uterine tumor77
Developmental Stage
TissuesTPM*
adult33
fetus30
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.5
adrenal gland12.8
appendix96.7
bone marrow12.8
cerebral cortex1.6
colon24
duodenum22.4
esophagus15.1
gallbladder53
heart muscle3.3
kidney6.1
liver16.3
lung17.4
lymph node115.1
ovary6.1
pancreas6
placenta3.6
prostate7.9
salivary gland8
skin5.9
small intestine71.7
spleen58.3
stomach43.1
testis7.4
thyroid gland3.2
urinary bladder31.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601721, gene) Baculoviral iap repeat-containing protein 3; BIRC3OMIM
2mucosa-associated lymphoid tissue lymphomaCGP


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