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> Protein (NX_Q13490)
Protein (NX_Q13490)
Protein
Gene SymbolBIRC2 to neXtProt (NX_Q13490)
DescriptionBaculoviral IAP repeat-containing protein 2
Chromosome11
Location11q22.2 (102217942 ~ 102249401) to Ensembl
Sequene Features : Isoforms 2, Variants 88, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of reactive oxygen species metabolic process
.regulation of cysteine-type endopeptidase activity
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
  + 40 more...
.protein N-terminus binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 3 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 88 12
2014-09-19protein level
2 65 12
2014-05-27protein level
2 65 13
2014-02-25protein level
2 65 13
2013-12-09protein level
2 46 13
2013-11-01protein level
2 44 10
2013-09-12protein level
2 44 10
2013-08-17protein level
2 44 10
2013-07-15protein level
2 36 4
2013-06-11protein level
2 36 4
2013-02-12protein level
2 21 3
2012-12-20protein level
1 20 3
2012-10-30protein level
1 29 3
2012-10-07protein level
1 29 3
2012-08-24protein level
1 27 3
2012-07-28protein level
1 27 3
2012-06-08protein level
1 32 3
2012-05-07protein level
1 22 3
2012-04-10protein level
1 22 3
2012-01-13protein level
1 12 3
2011-12-20protein level
1 12 3
2011-11-11protein level
1 12 3
2011-08-23protein level
1 12 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13490-1
3 23 7 69854.1283
NX_Q13490-2
0 23 7 64056.3653
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-514538,EBI-358522 RIPK2  
  .cellular response to muramyl dipeptide
.cellular response to peptidoglycan
.cellular response to lipoteichoic acid
  + 57 more...
.CARD domain binding
.protein homodimerization activity
.LIM domain binding
  + 4 more...
.protein complex
.vesicle
.cytoskeleton
  + 2 more...
2 EBI-514538,EBI-7964376 NMB  
  .arachidonic acid secretion
.negative regulation of hormone secretion
.positive regulation of hormone secretion
  + 6 more...
.hormone activity .neuron projection
.extracellular region
3 EBI-514538,EBI-744302 GFAP  
  .long-term synaptic potentiation
.Bergmann glial cell differentiation
.regulation of neurotransmitter uptake
  + 7 more...
.structural constituent of cytoskeleton .astrocyte end-foot
.cell body
.membrane
  + 3 more...
4 EBI-514538,EBI-523958 CASP7  
  .execution phase of apoptosis
.intrinsic apoptotic signaling pathway
.programmed cell death
  + 4 more...
.cysteine-type endopeptidase activity involved in execution phase of apoptosis
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-514538,EBI-516799 CASP9  
  .regulation of response to DNA damage stimulus
.intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
  + 23 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.protein kinase binding
.SH3 domain binding
  + 3 more...
.apoptosome
.cytosol
.mitochondrion
.nucleus
6 EBI-514538,EBI-4422308 RIPK4  
  .positive regulation of NF-kappaB transcription factor activity
.morphogenesis of an epithelium
.ATP binding
.protein serine/threonine kinase activity
.membrane
.cytoplasm
.nucleus
7 EBI-514538,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
8 EBI-514538,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
9 EBI-514538,EBI-358507 RIPK1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 48 more...
.death domain binding
.identical protein binding
.protein complex binding
  + 5 more...
.ripoptosome
.membrane raft
.receptor complex
  + 4 more...
10 EBI-514538,EBI-3923368 PPM1K  
  .protein dephosphorylation .metal ion binding
.protein serine/threonine phosphatase activity
.mitochondrial matrix
11 EBI-514538,EBI-517623 BIRC7  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.regulation of natural killer cell apoptotic process
.negative regulation of apoptotic process
  + 4 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.enzyme binding
.ligase activity
  + 3 more...
.Golgi apparatus
.cytoplasm
.nucleus
12 EBI-514538,EBI-1245604 EAF2  
  .negative regulation of epithelial cell proliferation involved in prostate gland development
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of cell growth
.apoptotic process
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.ELL-EAF complex
.nuclear speck
.transcription elongation factor complex
13 EBI-514538,EBI-746252 GCC1  
  .protein targeting to Golgi .N/A .plasma membrane
.Golgi apparatus
.cytoplasm
.Golgi membrane
14 EBI-514538,EBI-1058491 OTUB1  
  .negative regulation of double-strand break repair
.negative regulation of histone H2A K63-linked ubiquitination
.protein K48-linked deubiquitination
  + 3 more...
.ubiquitin binding
.ubiquitin protein ligase binding
.NEDD8-specific protease activity
.ubiquitin-specific protease activity
.extracellular exosome
.cytoplasm
15 EBI-514538,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
16 EBI-514538,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
17 EBI-514538,EBI-2851995 TNFRSF12A  
  .positive regulation of extrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
.regulation of wound healing
  + 5 more...
.N/A .integral component of membrane
.cell surface
.plasma membrane
.ruffle
18 EBI-514538,EBI-371876 EXOSC5  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.nuclear mRNA surveillance
  + 10 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
19 EBI-514538,EBI-517508 DIABLO  
  .intrinsic apoptotic signaling pathway
.neuron apoptotic process
.positive regulation of apoptotic process
  + 6 more...
.N/A .CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
20 EBI-514538,EBI-1049556 BOLA1  
  .N/A .N/A .mitochondrion
.extracellular region
21 EBI-514538,EBI-298250 RIPK3  
  .positive regulation of intrinsic apoptotic signaling pathway
.regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
.positive regulation of reactive oxygen species metabolic process
  + 35 more...
.identical protein binding
.protein complex binding
.ATP binding
  + 4 more...
.ripoptosome
.plasma membrane
.cytosol
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder66
blood40
bone marrow61
brain111
cervix20
connective tissue46
embryonic tissue23
esophagus49
eye4
heart11
intestine12
kidney28
liver63
lung8
lymph node89
mammary gland26
mouth181
muscle9
placenta42
prostate5
salivary gland49
skin9
spleen93
stomach10
testis158
thymus338
thyroid42
trachea791
uterus64
vascular58
Health State
TissuesTPM*
normal58
bladder carcinoma227
breast (mammary gland) tumor53
cervical tumor28
esophageal tumor57
gastrointestinal tumor25
germ cell tumor64
head and neck tumor89
kidney tumor14
leukemia10
liver tumor52
lymphoma13
non-neoplasia82
prostate cancer9
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult26
embryoid body14
blastocyst48
neonate64
fetus46
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.9
adrenal gland30.5
appendix30
bone marrow26.9
cerebral cortex19.2
colon26.4
duodenum22
esophagus17.9
gallbladder28.6
heart muscle15.6
kidney24.2
liver26.3
lung22.7
lymph node35.2
ovary22.7
pancreas15.7
placenta24.6
prostate22.6
salivary gland16.3
skin13.9
small intestine24.9
spleen24.8
stomach23.8
testis27.7
thyroid gland23.1
urinary bladder32.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowMedium
breastLow
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
pancreasLow
parathyroid glandLow
placentaMedium
rectumLow
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1Low
skin 2Medium
small intestineMedium
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601712, gene) Baculoviral iap repeat-containing protein 2; BIRC2OMIM


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