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> Protein (NX_Q13501)
Protein (NX_Q13501)
Protein
Gene SymbolSQSTM1 to neXtProt (NX_Q13501)
DescriptionSequestosome-1
Chromosome5
Location5q35.3 (179233388 ~ 179265078) to Ensembl
Sequene Features : Isoforms 2, Variants 64, PTMs 25 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 64 25
2014-09-19protein level
2 52 25
2014-05-27protein level
2 52 25
2014-02-25protein level
2 52 25
2013-12-09protein level
2 38 24
2013-11-01protein level
2 36 24
2013-09-12protein level
2 36 23
2013-08-17protein level
2 36 23
2013-07-15protein level
2 29 19
2013-06-11protein level
2 29 19
2013-02-12protein level
2 21 39
2012-12-20protein level
2 21 39
2012-10-30protein level
2 26 39
2012-10-07protein level
2 26 20
2012-08-24protein level
2 26 20
2012-07-28protein level
2 26 20
2012-06-08protein level
2 44 20
2012-05-07protein level
2 44 20
2012-04-10protein level
2 44 20
2012-01-13protein level
2 36 20
2011-12-20protein level
2 34 20
2011-11-11protein level
2 34 18
2011-08-23protein level
2 34 17
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13501-1
3 14 0 47656.7358
NX_Q13501-2
0 14 0 38604.3501
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-307104,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-307104,EBI-747185 BAG3  
  .regulation of cellular response to heat
.extrinsic apoptotic signaling pathway in absence of ligand
.cellular response to mechanical stimulus
  + 8 more...
.N/A .neuron projection
.Z disc
.plasma membrane
  + 2 more...
3 EBI-307104,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
4 EBI-307104,EBI-286199 PRKCI  
  .positive regulation of endothelial cell apoptotic process
.positive regulation of establishment of protein localization to plasma membrane
.tight junction assembly
  + 25 more...
.metal ion binding
.phospholipid binding
.ATP binding
  + 3 more...
.extracellular exosome
.intercellular bridge
.protein complex
  + 11 more...
5 EBI-307104,EBI-746453 RAD23A  
  .positive regulation of viral genome replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin-specific protease binding
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.cytoplasm
.nucleoplasm
.proteasome complex
6 EBI-307104,EBI-3939642 SESN2  
  .regulation of cAMP-dependent protein kinase activity
.regulation of response to reactive oxygen species
.regulation of gluconeogenesis involved in cellular glucose homeostasis
  + 10 more...
.N/A .cytosol
.cytoplasm
.nucleus
7 EBI-307104,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
8 EBI-307104,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
9 EBI-307104,EBI-751001 KEAP1  
  .cellular response to interleukin-4
.regulation of epidermal cell differentiation
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.transcription factor binding .Cul3-RING ubiquitin ligase complex
.midbody
.cytosol
  + 4 more...
10 EBI-307104,EBI-742698 NBR1  
  .protein oligomerization
.negative regulation of osteoblast differentiation
.regulation of stress-activated MAPK cascade
  + 2 more...
.mitogen-activated protein kinase binding
.ubiquitin binding
.zinc ion binding
.extracellular exosome
.M band
.cytoplasmic vesicle
  + 6 more...
11 EBI-307104,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
12 EBI-307104,EBI-6395541 FHOD3  
  .cardiac myofibril assembly
.actin filament network formation
.sarcomere organization
.negative regulation of actin filament polymerization
.N/A .Z disc
.striated muscle thin filament
13 EBI-307104,EBI-346595 SH3KBP1  
  .negative regulation of epidermal growth factor receptor signaling pathway
.cell migration
.regulation of cell shape
  + 5 more...
.N/A .synapse
.neuron projection
.cytoplasmic vesicle membrane
  + 5 more...
14 EBI-307104,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
15 EBI-307104,EBI-2603996 MAP1LC3C  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
16 EBI-307104,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
17 EBI-307104,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
18 EBI-307104,EBI-720768 MAP1LC3A  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.phosphatidylethanolamine binding
.microtubule binding
.phospholipid binding
.cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
19 EBI-307104,EBI-1047372 MALT1  
  .protein oligomerization
.nuclear export
.positive regulation of NF-kappaB transcription factor activity
  + 20 more...
.protein self-association
.peptidase activity
.signal transducer activity
  + 2 more...
.perinuclear region of cytoplasm
.protein complex
.CBM complex
  + 5 more...
20 EBI-307104,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
21 EBI-307104,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue1010
adrenal gland1001
ascites903
bladder602
blood351
bone349
bone marrow943
brain390
cervix659
connective tissue395
ear124
embryonic tissue126
esophagus396
eye502
heart223
intestine512
kidney521
larynx213
liver662
lung1182
lymph293
lymph node100
mammary gland2049
mouth302
muscle197
nerve386
ovary1842
pancreas749
parathyroid339
pharynx49
pituitary gland605
placenta837
prostate416
salivary gland1677
skin2011
spleen449
stomach449
testis268
thymus200
thyroid1438
tonsil235
trachea96
umbilical cord363
uterus633
vascular329
Health State
TissuesTPM*
normal392
adrenal tumor711
bladder carcinoma454
breast (mammary gland) tumor2825
cervical tumor869
chondrosarcoma1074
colorectal tumor790
esophageal tumor405
gastrointestinal tumor607
germ cell tumor349
glioma1044
head and neck tumor620
kidney tumor1045
leukemia328
liver tumor801
lung tumor2160
lymphoma263
non-neoplasia496
ovarian tumor2375
pancreatic tumor895
primitive neuroectodermal tumor of the CNS283
prostate cancer433
retinoblastoma107
skin tumor2975
soft tissue/muscle tissue tumor327
uterine tumor810
Developmental Stage
TissuesTPM*
adult739
embryoid body100
blastocyst130
neonate450
fetus147
infant297
juvenile395
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue148.5
adrenal gland208.6
appendix103.6
bone marrow117.1
cerebral cortex95.8
colon123.2
duodenum120.1
esophagus132.4
gallbladder255.7
heart muscle187.3
kidney133.3
liver181.2
lung154.8
lymph node105.8
ovary173.1
pancreas96.6
placenta188.8
prostate136.7
salivary gland145.7
skin88
small intestine107.3
spleen132.6
stomach185.6
testis75.1
thyroid gland250.8
urinary bladder211.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
kidneyMedium
liverLow
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601530, gene) Sequestosome 1; SQSTM1OMIM
2(#602080, phenotype) Paget disease of bone; PDBOMIM


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