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> Protein (NX_Q13503)
Protein (NX_Q13503)
Protein
Gene SymbolMED21 to neXtProt (NX_Q13503)
DescriptionMediator of RNA polymerase II transcription subunit 21
Chromosome12
Location12p11.23 (27175479 ~ 27219276) to Ensembl
Sequene Features : Isoforms 1, Variants 12, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.stem cell maintenance
.regulation of transcription from RNA polymerase II promoter
  + 2 more...
.DNA-directed RNA polymerase activity
.transcription coactivator activity
.mediator complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 12 1
2014-09-19protein level
1 8 1
2014-05-27protein level
1 8 1
2014-02-25protein level
1 8 1
2013-12-09protein level
1 5 1
2013-11-01protein level
1 4 1
2013-09-12protein level
1 4 1
2013-08-17protein level
1 4 1
2013-07-15protein level
1 1 0
2013-06-11protein level
1 1 0
2013-02-12protein level
1 0 0
2012-12-20protein level
1 0 0
2012-10-30protein level
1 0 0
2012-10-07protein level
1 0 0
2012-08-24protein level
1 0 0
2012-07-28protein level
1 0 0
2012-06-08protein level
1 1 0
2012-05-07protein level
1 3 0
2012-04-10protein level
1 3 0
2012-01-13protein level
1 1 0
2011-12-20protein level
1 1 0
2011-11-11protein level
1 1 0
2011-08-23protein level
1 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13503-1
6 0 0 15554.6431
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-394678,EBI-10172867 SSC5D  
  .negative regulation of interleukin-8 secretion
.defense response to Gram-positive bacterium
.defense response to Gram-negative bacterium
  + 4 more...
.extracellular matrix binding
.laminin binding
.scavenger receptor activity
.fibronectin binding
.extracellular matrix
.membrane
.cytoplasm
  + 2 more...
2 EBI-394678,EBI-751857 MAGEB4  
  .N/A .N/A .N/A
3 EBI-394678,EBI-625509 ZNF655  
  .negative regulation of G1/S transition of mitotic cell cycle
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
4 EBI-394678,EBI-394653 MED9  
  .N/A .RNA polymerase II transcription cofactor activity .mediator complex
5 EBI-394678,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites25
bladder200
blood98
bone55
bone marrow41
brain49
connective tissue40
embryonic tissue37
esophagus99
eye28
heart33
intestine34
kidney61
larynx85
liver9
lung17
mammary gland105
mouth45
muscle28
nerve64
ovary59
parathyroid97
pharynx220
pituitary gland60
placenta14
prostate63
skin23
spleen18
stomach10
testis110
thymus62
thyroid21
trachea57
uterus34
vascular19
Health State
TissuesTPM*
normal46
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor96
chondrosarcoma96
colorectal tumor44
esophageal tumor57
gastrointestinal tumor16
germ cell tumor106
glioma46
head and neck tumor44
kidney tumor43
leukemia21
liver tumor10
lung tumor19
lymphoma69
non-neoplasia31
ovarian tumor52
primitive neuroectodermal tumor of the CNS70
prostate cancer48
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult46
embryoid body14
blastocyst16
neonate32
fetus46
infant297
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.8
adrenal gland34.8
appendix16.1
bone marrow22.1
cerebral cortex14.8
colon17.7
duodenum15.3
esophagus29.3
gallbladder21.8
heart muscle27.4
kidney28.2
liver10.7
lung21.2
lymph node17
ovary30.8
pancreas8.8
placenta19.2
prostate23.4
salivary gland16.6
skin15.9
small intestine13.9
spleen14.4
stomach17.7
testis30.4
thyroid gland24.7
urinary bladder27.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603800, gene) Mediator complex subunit 21; MED21OMIM


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