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> Protein (NX_Q13523)
Protein (NX_Q13523)
Protein
Gene SymbolPRPF4B to neXtProt (NX_Q13523)
DescriptionSerine/threonine-protein kinase PRP4 homolog
Chromosome6
Location6p25.2 (4021501 ~ 4065217) to Ensembl
Sequene Features : Isoforms 1, Variants 124, PTMs 43 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA splicing
.protein phosphorylation
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.catalytic step 2 spliceosome
.chromosome
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 124 43
2014-09-19protein level
1 95 43
2014-05-27protein level
1 95 43
2014-02-25protein level
1 95 42
2013-12-09protein level
1 78 42
2013-11-01protein level
1 74 42
2013-09-12protein level
1 74 42
2013-08-17protein level
1 74 42
2013-07-15protein level
1 50 41
2013-06-11protein level
1 50 41
2013-02-12protein level
1 22 47
2012-12-20protein level
1 23 47
2012-10-30protein level
1 27 47
2012-10-07protein level
1 27 49
2012-08-24protein level
1 26 49
2012-07-28protein level
1 26 49
2012-06-08protein level
1 33 49
2012-05-07protein level
1 21 49
2012-04-10protein level
1 21 49
2012-01-13protein level
1 16 49
2011-12-20protein level
1 16 49
2011-11-11protein level
1 16 42
2011-08-23protein level
1 16 42
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13523-1
31 0 0 116915.3284
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-395940,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
2 EBI-395940,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
3 EBI-395940,EBI-710067 POLR3F  
  .defense response to virus
.positive regulation of innate immune response
.innate immune response
  + 7 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase III complex
.nucleoplasm
4 EBI-395940,EBI-1255893 KLF13  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
.negative regulation of cell proliferation
.transcription from RNA polymerase II promoter
.metal ion binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder133
blood49
bone83
bone marrow143
brain57
cervix20
connective tissue60
ear124
embryonic tissue79
esophagus99
eye62
heart44
intestine60
kidney90
liver112
lung71
lymph135
lymph node133
mammary gland59
mouth105
muscle84
nerve64
ovary9
pancreas37
parathyroid97
pharynx122
placenta81
prostate58
skin14
spleen74
stomach114
testis80
thymus188
thyroid64
trachea251
uterus73
vascular19
Health State
TissuesTPM*
normal71
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma96
colorectal tumor62
esophageal tumor115
gastrointestinal tumor92
germ cell tumor87
glioma18
head and neck tumor74
kidney tumor87
leukemia105
liver tumor72
lung tumor29
lymphoma124
non-neoplasia72
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS31
prostate cancer48
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor39
uterine tumor55
Developmental Stage
TissuesTPM*
adult73
embryoid body42
blastocyst97
neonate32
fetus82
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.8
adrenal gland29.6
appendix40.8
bone marrow53.6
cerebral cortex21.5
colon27.7
duodenum32.2
esophagus28.6
gallbladder29.9
heart muscle18.4
kidney24.2
liver14.7
lung28.8
lymph node51
ovary38.5
pancreas14.8
placenta32.1
prostate32.3
salivary gland21.6
skin27
small intestine33.2
spleen40
stomach30
testis26.8
thyroid gland34.4
urinary bladder33.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602338, gene) Precursor mrna-processing factor 4, s. pombe, homolog of, b; PRPF4BOMIM


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