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> Protein (NX_Q13526)
Protein (NX_Q13526)
Protein
Gene SymbolPIN1 to neXtProt (NX_Q13526)
DescriptionPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Chromosome19
Location19p13.2 (9945933 ~ 9960358) to Ensembl
Sequene Features : Isoforms 1, Variants 13, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 13 7
2014-09-19protein level
1 10 7
2014-05-27protein level
1 10 8
2014-02-25protein level
1 10 8
2013-12-09protein level
1 8 8
2013-11-01protein level
1 8 7
2013-09-12protein level
1 8 7
2013-08-17protein level
1 8 7
2013-07-15protein level
1 7 4
2013-06-11protein level
1 7 4
2013-02-12protein level
1 5 4
2012-12-20protein level
1 5 4
2012-10-30protein level
1 6 4
2012-10-07protein level
1 6 4
2012-08-24protein level
1 5 4
2012-07-28protein level
1 5 4
2012-06-08protein level
1 8 4
2012-05-07protein level
1 5 4
2012-04-10protein level
1 5 4
2012-01-13protein level
1 4 4
2011-12-20protein level
1 4 4
2011-11-11protein level
1 3 3
2011-08-23protein level
1 3 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13526-1
7 0 0 18231.9181
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714158,EBI-740434 ZBTB7B  
  .cell differentiation
.positive regulation of gene expression
.ectoderm development
  + 3 more...
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
2 EBI-714158,EBI-723574 ZBTB22  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
3 EBI-714158,EBI-983612 FOXP2  
  .positive regulation of epithelial cell proliferation involved in lung morphogenesis
.righting reflex
.smooth muscle tissue development
  + 12 more...
.metal ion binding
.sequence-specific DNA binding
.protein homodimerization activity
  + 4 more...
.nucleus
4 EBI-714158,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-714158,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
6 EBI-714158,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
7 EBI-714158,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
8 EBI-714158,EBI-302641 APP  
  .membrane organization
.smooth endoplasmic reticulum calcium ion homeostasis
.neuron apoptotic process
  + 41 more...
.PTB domain binding
.transition metal ion binding
.identical protein binding
  + 7 more...
.extracellular exosome
.spindle midzone
.perinuclear region of cytoplasm
  + 27 more...
9 EBI-714158,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
10 EBI-714158,EBI-740135 CBS  
  .hydrogen sulfide biosynthetic process
.oxidation-reduction process
.homocysteine metabolic process
  + 12 more...
.S-adenosyl-L-methionine binding
.modified amino acid binding
.nitric oxide binding
  + 11 more...
.intracellular membrane-bounded organelle
.cytosol
.nucleolus
.nucleus
11 EBI-714158,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
12 EBI-714158,EBI-354900 MAP3K8  
  .regulation of apoptotic process
.activation of protein kinase activity
.T cell costimulation
  + 5 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.magnesium ion binding
.cytosol
.cytoplasm
13 EBI-714158,EBI-636374 NOTCH1  
  .negative regulation of endothelial cell chemotaxis
.negative regulation of pro-B cell differentiation
.negative regulation of anoikis
  + 125 more...
.sequence-specific DNA binding
.chromatin DNA binding
.enzyme binding
  + 6 more...
.receptor complex
.integral component of membrane
.cell surface
  + 9 more...
14 EBI-714158,EBI-358664 IRAK1  
  .cellular response to hypoxia
.response to interleukin-1
.interleukin-1-mediated signaling pathway
  + 39 more...
.protein heterodimerization activity
.protein homodimerization activity
.kinase activity
  + 5 more...
.interleukin-1 receptor complex
.endosome membrane
.plasma membrane
  + 4 more...
15 EBI-714158,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
16 EBI-714158,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
17 EBI-714158,EBI-2967304 ADARB1  
  .regulation of cell cycle
.defense response to virus
.innate immune response
  + 10 more...
.metal ion binding
.poly(A) RNA binding
.adenosine deaminase activity
  + 4 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
18 EBI-714158,EBI-9523517 ARHGAP8  
  .positive regulation of ERK1 and ERK2 cascade
.regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
  + 2 more...
.GTPase activator activity .cytosol
.cytoplasm
19 EBI-714158,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
20 EBI-714158,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
21 EBI-714158,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
22 EBI-714158,EBI-2865100 SP140  
  .defense response
.regulation of transcription, DNA-templated
.chromatin remodeling
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.PML body
.cytoplasm
.nucleoplasm
  + 2 more...
23 EBI-714158,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
24 EBI-714158,EBI-976402 RUNX2  
  .positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
.cellular response to BMP stimulus
.stem cell differentiation
  + 27 more...
.ATP binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 4 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
.nuclear chromatin
25 EBI-714158,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
26 EBI-714158,EBI-1646959 CDK10  
  .positive regulation of MAPK cascade
.negative regulation of cell proliferation
.traversing start control point of mitotic cell cycle
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
27 EBI-714158,EBI-350527 NONO  
  .negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.negative regulation of transcription, DNA-templated
.regulation of circadian rhythm
  + 6 more...
.poly(A) RNA binding
.identical protein binding
.core promoter binding
.nucleotide binding
.paraspeckles
.nuclear speck
.nuclear matrix
  + 4 more...
28 EBI-714158,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
29 EBI-714158,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
30 EBI-714158,EBI-8641936 NAB2  
  .regulation of epidermis development
.myelination
.negative regulation of transcription from RNA polymerase III promoter
  + 5 more...
.transcription corepressor activity .nucleus
31 EBI-714158,EBI-3891843 AMOT  
  .positive regulation of stress fiber assembly
.positive regulation of cell size
.positive regulation of blood vessel endothelial cell migration
  + 16 more...
.angiostatin binding
.receptor activity
.endocytic vesicle
.lamellipodium
.integral component of membrane
  + 8 more...
32 EBI-714158,EBI-10179526 CCDC184  
  .N/A .N/A .cytoplasm
33 EBI-714158,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
34 EBI-714158,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
35 EBI-714158,EBI-2838246 ANKRD40  
  .N/A .N/A .N/A
36 EBI-714158,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
37 EBI-714158,EBI-743815 RAI1  
  .positive regulation of transcription, DNA-templated
.negative regulation of multicellular organism growth
.circadian regulation of gene expression
  + 2 more...
.enhancer binding
.zinc ion binding
.mitochondrion
.nucleoplasm
.nucleus
38 EBI-714158,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
39 EBI-714158,EBI-359964 TAB3  
  .nucleotide-binding oligomerization domain containing signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 19 more...
.zinc ion binding .extracellular exosome
.endosome membrane
.plasma membrane
  + 3 more...
40 EBI-714158,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
41 EBI-714158,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
42 EBI-714158,EBI-745786 ZMIZ2  
  .positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.ligand-dependent nuclear receptor transcription coactivator activity
.zinc ion binding
.nuclear replication fork
.mitochondrion
.nucleoplasm
.nucleus
43 EBI-714158,EBI-742887 CEP76  
  .regulation of centriole replication
.organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .protein complex
.cytosol
.centriole
.centrosome
44 EBI-714158,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
45 EBI-714158,EBI-741671 CNKSR1  
  .Rho protein signal transduction
.Ras protein signal transduction
.transmembrane receptor protein tyrosine kinase signaling pathway
.protein binding, bridging .cell cortex
.cell-cell junction
.plasma membrane
46 EBI-714158,EBI-752007 JAKMIP2  
  .N/A .N/A .Golgi apparatus
47 EBI-714158,EBI-395708 ZBTB9  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
48 EBI-714158,EBI-2560879 PRRC1  
  .N/A .N/A .Golgi apparatus
49 EBI-714158,EBI-5460660 HEXIM2  
  .negative regulation of transcription, DNA-templated
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.snRNA binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleoplasm
.nucleus
50 EBI-714158,EBI-10203615 RBBP8  
  .meiotic cell cycle
.cell division
.G2 DNA damage checkpoint
  + 10 more...
.damaged DNA binding
.RNA polymerase II transcription corepressor activity
.RNA polymerase II repressing transcription factor binding
.single-stranded DNA endodeoxyribonuclease activity
.transcriptional repressor complex
.nucleolus
.nucleoplasm
.nucleus
51 EBI-714158,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
52 EBI-714158,EBI-6690555 SULT4A1  
  .3'-phosphoadenosine 5'-phosphosulfate metabolic process
.small molecule metabolic process
.steroid metabolic process
.xenobiotic metabolic process
.sulfotransferase activity .cytosol
53 EBI-714158,EBI-741350 THAP7  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.C2H2 zinc finger domain binding
.protein N-terminus binding
.metal ion binding
.DNA binding
.nuclear speck
.chromosome
54 EBI-714158,EBI-2902395 SSBP3  
  .positive regulation of anterior head development
.head morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
  + 6 more...
.single-stranded DNA binding .protein complex
.nucleus
55 EBI-714158,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
56 EBI-714158,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
57 EBI-714158,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
58 EBI-714158,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
59 EBI-714158,EBI-739485 TSC22D4  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.sequence-specific DNA binding transcription factor activity .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
blood40
bone55
brain60
cervix61
connective tissue20
embryonic tissue61
eye100
heart67
intestine51
kidney28
liver14
lung71
lymph45
lymph node33
mammary gland19
muscle37
nerve128
ovary39
pancreas79
parathyroid194
pituitary gland121
placenta24
prostate58
salivary gland197
skin52
spleen37
testis176
thymus50
tonsil117
uterus51
Health State
TissuesTPM*
normal48
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma84
colorectal tumor35
gastrointestinal tumor16
germ cell tumor34
glioma139
head and neck tumor37
kidney tumor58
leukemia42
liver tumor20
lung tumor48
lymphoma41
non-neoplasia31
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS86
prostate cancer48
retinoblastoma193
skin tumor63
soft tissue/muscle tissue tumor39
uterine tumor22
Developmental Stage
TissuesTPM*
adult52
embryoid body71
blastocyst48
fetus57
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36.3
adrenal gland40.7
appendix27.2
bone marrow30.4
cerebral cortex60.4
colon25.5
duodenum30.5
esophagus13.6
gallbladder15.7
heart muscle37.1
kidney37.1
liver14.5
lung25.1
lymph node28.6
ovary17.7
pancreas17.3
placenta22.5
prostate47
salivary gland24.4
skin14.3
small intestine28.6
spleen31.3
stomach29.1
testis67.2
thyroid gland14
urinary bladder14.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601052, gene) Peptidyl-prolyl cis/trans isomerase, nima-interacting, 1; PIN1OMIM


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