Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q13547)
Protein (NX_Q13547)
Protein
Gene SymbolHDAC1 to neXtProt (NX_Q13547)
DescriptionHistone deacetylase 1
Chromosome1
Location1p35.1 (32757687 ~ 32799236) to Ensembl
Sequene Features : Isoforms 1, Variants 40, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 40 15
2014-09-19protein level
1 28 15
2014-05-27protein level
1 28 19
2014-02-25protein level
1 28 18
2013-12-09protein level
1 23 18
2013-11-01protein level
1 23 15
2013-09-12protein level
1 23 15
2013-08-17protein level
1 23 15
2013-07-15protein level
1 16 10
2013-06-11protein level
1 16 10
2013-02-12protein level
1 9 11
2012-12-20protein level
1 9 11
2012-10-30protein level
1 9 11
2012-10-07protein level
1 9 11
2012-08-24protein level
1 8 11
2012-07-28protein level
1 8 11
2012-06-08protein level
1 20 11
2012-05-07protein level
1 14 11
2012-04-10protein level
1 14 11
2012-01-13protein level
1 17 11
2011-12-20protein level
1 17 11
2011-11-11protein level
1 17 13
2011-08-23protein level
1 17 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13547-1
16 0 7 55067.5743
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-301834,EBI-1044156 SAP18  
  .negative regulation of nucleic acid-templated transcription
.negative regulation of mRNA splicing, via spliceosome
.negative regulation of gene expression, epigenetic
  + 9 more...
.poly(A) RNA binding
.transcription corepressor activity
.ASAP complex
.nuclear speck
.cytoplasm
  + 2 more...
2 EBI-301834,EBI-349968 SUV39H1  
  .cellular response to hypoxia
.rhythmic process
.negative regulation of transcription, DNA-templated
  + 15 more...
.protein N-terminus binding
.histone methyltransferase activity (H3-K9 specific)
.histone methyltransferase activity
  + 5 more...
.rDNA heterochromatin
.chromatin silencing complex
.nucleoplasm
  + 5 more...
3 EBI-301834,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
4 EBI-301834,EBI-491274 RB1  
  .negative regulation of G1/S transition of mitotic cell cycle
.hepatocyte apoptotic process
.regulation of centromere complex assembly
  + 39 more...
.phosphoprotein binding
.androgen receptor binding
.identical protein binding
  + 7 more...
.Rb-E2F complex
.PML body
.SWI/SNF complex
  + 4 more...
5 EBI-301834,EBI-78579 NPM1  
  .regulation of eIF2 alpha phosphorylation by dsRNA
.regulation of endoribonuclease activity
.protein oligomerization
  + 20 more...
.unfolded protein binding
.NF-kappaB binding
.protein heterodimerization activity
  + 10 more...
.spindle pole centrosome
.ribonucleoprotein complex
.membrane
  + 7 more...
6 EBI-301834,EBI-351962 DDX5  
  .regulation of skeletal muscle cell differentiation
.intrinsic apoptotic signaling pathway by p53 class mediator
.regulation of androgen receptor signaling pathway
  + 13 more...
.androgen receptor binding
.poly(A) RNA binding
.pre-mRNA binding
  + 5 more...
.catalytic step 2 spliceosome
.extracellular exosome
.ribonucleoprotein complex
  + 5 more...
7 EBI-301834,EBI-300010 NFKB1  
  .positive regulation of miRNA metabolic process
.positive regulation of hyaluronan biosynthetic process
.positive regulation of canonical Wnt signaling pathway
  + 45 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.identical protein binding
  + 10 more...
.I-kappaB/NF-kappaB complex
.cytosol
.mitochondrion
  + 3 more...
8 EBI-301834,EBI-740978 MAGEA1  
  .negative regulation of Notch signaling pathway
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.histone deacetylase binding .plasma membrane
.cytoplasm
.nucleus
9 EBI-301834,EBI-396176 HCFC1  
  .protein stabilization
.positive regulation of cell cycle
.histone H4-K16 acetylation
  + 12 more...
.identical protein binding
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.MLL1 complex
.MLL5-L complex
.Set1C/COMPASS complex
  + 7 more...
10 EBI-301834,EBI-302023 HIST2H4A  
  .protein heterotetramerization
.negative regulation of gene expression, epigenetic
.negative regulation of megakaryocyte differentiation
  + 13 more...
.poly(A) RNA binding
.histone binding
.histone demethylase activity (H4-K20 specific)
.DNA binding
.extracellular exosome
.protein complex
.membrane
  + 5 more...
11 EBI-301834,EBI-347804 CSNK2A1  
  .mitotic spindle checkpoint
.chaperone-mediated protein folding
.rhythmic process
  + 12 more...
.Hsp90 protein binding
.protein N-terminus binding
.ATP binding
.protein serine/threonine kinase activity
.NuRD complex
.Sin3 complex
.plasma membrane
  + 2 more...
12 EBI-301834,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
13 EBI-301834,EBI-620823 RBBP4  
  .regulation of cell cycle
.negative regulation of gene expression, epigenetic
.ATP-dependent chromatin remodeling
  + 15 more...
.histone deacetylase binding
.histone binding
.protein complex
.ESC/E(Z) complex
.CAF-1 complex
  + 6 more...
14 EBI-301834,EBI-714236 MTA1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of protein autoubiquitination
.regulation of inflammatory response
  + 11 more...
.zinc ion binding
.transcription corepressor activity
.transcription coactivator activity
  + 5 more...
.intracellular membrane-bounded organelle
.NuRD complex
.microtubule
  + 4 more...
15 EBI-301834,EBI-372916 CHD4  
  .spindle assembly
.ATP-dependent chromatin remodeling
.DNA duplex unwinding
  + 3 more...
.zinc ion binding
.ATP binding
.ATP-dependent DNA helicase activity
  + 2 more...
.protein complex
.NuRD complex
.membrane
  + 5 more...
16 EBI-301834,EBI-1210388 ARID5B  
  .fat pad development
.adipose tissue development
.face morphogenesis
  + 19 more...
.transcription regulatory region DNA binding
.DNA binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
17 EBI-301834,EBI-352227 RBBP7  
  .cellular heat acclimation
.negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
  + 10 more...
.RNA binding .ESC/E(Z) complex
.NuRD complex
.nucleoplasm
.nucleus
18 EBI-301834,EBI-1227043 E4F1  
  .mitotic cell cycle arrest
.cell division
.regulation of growth
  + 8 more...
.metal ion binding
.cAMP response element binding
.ligase activity
  + 6 more...
.spindle
.cytoplasm
.nucleoplasm
19 EBI-301834,EBI-6598617 C16orf87  
  .N/A .N/A .N/A
20 EBI-301834,EBI-1211456 DHX30  
  .RNA processing .poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
  + 2 more...
.mitochondrial nucleoid
.mitochondrion
.cytoplasm
.nucleus
21 EBI-301834,EBI-3504940 MIER1  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.positive regulation of chromatin silencing
.signal transduction
.transcription, DNA-templated
.signal transducer activity
.chromatin binding
.DNA binding
.transcriptional repressor complex
.cytoplasm
.nucleoplasm
22 EBI-301834,EBI-744483 EID3  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 4 more...
.identical protein binding .Smc5-Smc6 complex
.cytoplasm
.nucleoplasm
.chromosome, telomeric region
23 EBI-301834,EBI-301821 HDAC2  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of protein deacetylation
.negative regulation of canonical Wnt signaling pathway
  + 44 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 14 more...
.protein complex
.ESC/E(Z) complex
.NuRD complex
  + 8 more...
24 EBI-301834,EBI-5280703 DDX17  
  .regulation of skeletal muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of intracellular estrogen receptor signaling pathway
  + 4 more...
.poly(A) RNA binding
.estrogen receptor binding
.RNA-dependent ATPase activity
  + 5 more...
.membrane
.cytoplasm
.nucleolus
  + 2 more...
25 EBI-301834,EBI-744366 EHMT2  
  .histone H3-K27 methylation
.histone H3-K9 methylation
.histone lysine methylation
  + 6 more...
.C2H2 zinc finger domain binding
.histone methyltransferase activity (H3-K27 specific)
.histone methyltransferase activity (H3-K9 specific)
  + 4 more...
.intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
.nucleoplasm
  + 2 more...
26 EBI-301834,EBI-6597774 PWWP2A  
  .N/A .N/A .N/A
27 EBI-301834,EBI-949368 GFI1  
  .cellular response to lipopolysaccharide
.positive regulation of interleukin-6-mediated signaling pathway
.negative regulation of transcription, DNA-templated
  + 15 more...
.transcription regulatory region DNA binding
.zinc ion binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.transcriptional repressor complex
.nuclear body
.nuclear matrix
.nucleus
28 EBI-301834,EBI-6597578 BCL11B  
  .olfactory bulb axon guidance
.thymus development
.alpha-beta T cell differentiation
  + 15 more...
.metal ion binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
29 EBI-301834,EBI-714781 BRMS1  
  .positive regulation of anoikis
.positive regulation of protein deacetylation
.negative regulation of transcription, DNA-templated
  + 6 more...
.NF-kappaB binding
.histone deacetylase binding
.Sin3-type complex
.cytoplasm
.nucleoplasm
.nucleus
30 EBI-301834,EBI-741906 FAM60A  
  .negative regulation of cell migration .N/A .Sin3 complex
31 EBI-301834,EBI-4292031 PRDM5  
  .histone H3-K9 methylation
.negative regulation of transcription, DNA-templated
.histone deacetylation
  + 2 more...
.repressing transcription factor binding
.metal ion binding
.transcription regulatory region DNA binding
  + 4 more...
.nucleus
32 EBI-301834,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
33 EBI-301834,EBI-867196 MBD1  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.methyl-CpG binding
.zinc ion binding
.transcription corepressor activity
  + 2 more...
.nuclear speck
.nuclear matrix
.cytoplasm
  + 2 more...
34 EBI-301834,EBI-740967 DNMT3L  
  .negative regulation of transcription, DNA-templated
.positive regulation of catalytic activity
.regulation of gene expression, epigenetic
  + 5 more...
.metal ion binding
.enzyme binding
.enzyme activator activity
.cytosol
.nucleus
35 EBI-301834,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
36 EBI-301834,EBI-7216962 NR2E3  
  .retina development in camera-type eye
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of rhodopsin gene expression
  + 10 more...
.sequence-specific DNA binding
.zinc ion binding
.ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
.steroid hormone receptor activity
.transcription factor complex
.nucleoplasm
.nucleus
37 EBI-301834,EBI-80830 NCOR2  
  .regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
.small molecule metabolic process
.cellular lipid metabolic process
  + 7 more...
.protein N-terminus binding
.histone deacetylase binding
.Notch binding
  + 3 more...
.transcriptional repressor complex
.nuclear body
.nuclear matrix
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites276
bladder234
blood229
bone209
bone marrow61
brain40
cervix103
connective tissue60
ear62
embryonic tissue192
esophagus99
eye95
heart89
intestine318
kidney132
larynx42
liver73
lung164
lymph586
lymph node189
mammary gland707
mouth1829
muscle37
ovary187
pancreas149
parathyroid48
pharynx270
pituitary gland121
placenta88
prostate105
salivary gland148
skin109
spleen37
stomach2257
testis59
thymus37
thyroid236
tonsil587
uterus168
vascular77
Health State
TissuesTPM*
normal92
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor1127
cervical tumor144
chondrosarcoma253
colorectal tumor506
esophageal tumor115
gastrointestinal tumor1924
germ cell tumor110
glioma74
head and neck tumor986
kidney tumor261
leukemia211
liver tumor72
lung tumor175
lymphoma415
non-neoplasia72
ovarian tumor170
pancreatic tumor228
primitive neuroectodermal tumor of the CNS165
prostate cancer125
retinoblastoma43
skin tumor143
soft tissue/muscle tissue tumor79
uterine tumor310
Developmental Stage
TissuesTPM*
adult334
embryoid body228
blastocyst211
neonate32
fetus82
juvenile215
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29
adrenal gland48.7
appendix94.5
bone marrow46.3
cerebral cortex15.7
colon131.8
duodenum81.2
esophagus75.5
gallbladder75.1
heart muscle28.9
kidney54
liver28.9
lung49
lymph node135.2
ovary75.3
pancreas21.9
placenta61.9
prostate70.6
salivary gland44.7
skin44.6
small intestine85.6
spleen77.6
stomach99.8
testis51.7
thyroid gland95.3
urinary bladder82.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryHigh
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skin 1High
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601241, gene) Histone deacetylase 1; HDAC1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center