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> Protein (NX_Q13554)
Protein (NX_Q13554)
Protein
Gene SymbolCAMK2B to neXtProt (NX_Q13554)
DescriptionCalcium/calmodulin-dependent protein kinase type II subunit beta
Chromosome7
Location7p13 (44256749 ~ 44374176) to Ensembl
Sequene Features : Isoforms 8, Variants 61, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.regulation of cellular response to heat
.positive regulation of synapse maturation
  + 22 more...
.protein homodimerization activity
.ATP binding
.calmodulin-dependent protein kinase activity
.spindle midzone
.sarcoplasmic reticulum membrane
.endocytic vesicle membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 61 4
2014-09-19protein level
8 36 4
2014-05-27protein level
8 35 8
2014-02-25protein level
8 35 8
2013-12-09protein level
8 30 8
2013-11-01protein level
8 27 8
2013-09-12protein level
8 27 10
2013-08-17protein level
8 27 10
2013-07-15protein level
8 14 9
2013-06-11protein level
8 14 9
2013-02-12protein level
8 6 65
2012-12-20protein level
8 7 65
2012-10-30protein level
8 7 65
2012-10-07protein level
8 7 9
2012-08-24protein level
8 3 9
2012-07-28protein level
8 3 9
2012-06-08protein level
8 6 9
2012-05-07protein level
8 6 9
2012-04-10protein level
8 6 9
2012-01-13protein level
8 8 9
2011-12-20protein level
8 8 9
2011-11-11protein level
8 8 8
2011-08-23protein level
8 5 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13554-1
6 15 11 72631.774
NX_Q13554-2
0 15 11 60348.4617
NX_Q13554-3
1 12 11 56343.4796
NX_Q13554-4
0 11 11 54039.279
NX_Q13554-5
0 14 11 57972.3271
NX_Q13554-6
2 9 11 55187.9114
NX_Q13554-7
0 10 11 50922.7406
NX_Q13554-8
0 14 11 57901.2902
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1058722,EBI-948905 ACOT7  
  .palmitic acid biosynthetic process
.medium-chain fatty acid biosynthetic process
.long-chain fatty-acyl-CoA catabolic process
  + 3 more...
.carboxylic ester hydrolase activity
.protein homodimerization activity
.long-chain fatty acyl-CoA binding
  + 2 more...
.extracellular exosome
.cell body
.neuron projection
  + 4 more...
2 EBI-1058722,EBI-746056 RBFOX2  
  .neuromuscular process controlling balance
.dendrite morphogenesis
.negative regulation of transcription, DNA-templated
  + 8 more...
.poly(A) RNA binding
.transcription factor binding
.mRNA binding
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-1058722,EBI-10217483 KRTAP10-11  
  .N/A .N/A .keratin filament
4 EBI-1058722,EBI-750871 RAP2B  
  .platelet aggregation
.regulation of protein tyrosine kinase activity
.Rap protein signal transduction
  + 4 more...
.GDP binding
.GTP binding
.extracellular exosome
.recycling endosome membrane
.membrane raft
  + 5 more...
5 EBI-1058722,EBI-354380 RPL11  
  .cellular protein metabolic process
.ribosomal large subunit biogenesis
.protein localization to nucleus
  + 12 more...
.poly(A) RNA binding
.rRNA binding
.structural constituent of ribosome
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
6 EBI-1058722,EBI-5917279 AP5B1  
  .endosomal transport
.protein transport
.N/A .AP-type membrane coat adaptor complex
.lysosomal membrane
7 EBI-1058722,EBI-1048945 KRTAP19-5  
  .N/A .N/A .intermediate filament
8 EBI-1058722,EBI-10241353 KRTAP19-7  
  .N/A .N/A .intermediate filament
9 EBI-1058722,EBI-10248098 SPRYD7  
  .N/A .N/A .N/A
10 EBI-1058722,EBI-9526213 TTC5  
  .positive regulation of transcription from RNA polymerase II promoter
.DNA repair
.chromatin binding
.DNA binding
.cytoplasm
.nucleoplasm
11 EBI-1058722,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
12 EBI-1058722,EBI-740559 PHKB  
  .small molecule metabolic process
.protein phosphorylation
.generation of precursor metabolites and energy
  + 4 more...
.phosphorylase kinase activity
.hydrolase activity, hydrolyzing O-glycosyl compounds
.phosphorylase kinase complex
.plasma membrane
.cytosol
13 EBI-1058722,EBI-366525 POP5  
  .tRNA processing .ribonuclease P activity .nucleolar ribonuclease P complex
14 EBI-1058722,EBI-394640 MED18  
  .N/A .RNA polymerase II transcription cofactor activity .mediator complex
15 EBI-1058722,EBI-9089805 SEMA4G  
  .cell differentiation
.nervous system development
.receptor activity .integral component of membrane
.plasma membrane
16 EBI-1058722,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
17 EBI-1058722,EBI-77889 MAD2L2  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of cell-cell adhesion mediated by cadherin
.negative regulation of canonical Wnt signaling pathway
  + 19 more...
.JUN kinase binding
.RNA polymerase II activating transcription factor binding
.zeta DNA polymerase complex
.spindle
.cytoplasm
  + 2 more...
18 EBI-1058722,EBI-5453723 MRPL11  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain204
eye81
heart33
kidney37
larynx42
liver4
lung20
lymph node122
mammary gland13
muscle75
nerve128
pancreas121
pituitary gland60
placenta3
prostate10
testis32
uterus4
Health State
TissuesTPM*
normal94
germ cell tumor15
glioma139
head and neck tumor7
kidney tumor116
lung tumor29
non-neoplasia62
pancreatic tumor47
primitive neuroectodermal tumor of the CNS7
retinoblastoma86
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult40
fetus84
infant212
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland10.5
cerebral cortex99.4
esophagus1.3
heart muscle47
liver2.4
pancreas1.7
prostate4.3
skin1
small intestine1
stomach2.7
testis2.7
thyroid gland8.1
Tissues
TissuesExpression level
cerebellumHigh
cerebral cortexHigh
epididymisLow
gallbladderLow
heart muscleMedium
hippocampusMedium
lateral ventricleHigh
prostateLow
seminal vesicleLow
skeletal muscleLow
testisLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607707, gene) Calcium/calmodulin-dependent protein kinase ii-beta; CAMK2BOMIM


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