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> Protein (NX_Q13557)
Protein (NX_Q13557)
Protein
Gene SymbolCAMK2D to neXtProt (NX_Q13557)
DescriptionCalcium/calmodulin-dependent protein kinase type II subunit delta
Chromosome4
Location4q26 (114372188 ~ 114683083) to Ensembl
Sequene Features : Isoforms 10, Variants 53, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of sodium ion transmembrane transporter activity
.regulation of generation of L-type calcium current
.negative regulation of sodium ion transmembrane transport
  + 41 more...
.ion channel binding
.protein homodimerization activity
.titin binding
  + 5 more...
.perinuclear region of cytoplasm
.axon initial segment
.neuronal cell body
  + 12 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
10 53 12
2014-09-19protein level
10 42 12
2014-05-27protein level
10 42 14
2014-02-25protein level
10 42 13
2013-12-09protein level
10 35 13
2013-11-01protein level
10 32 12
2013-09-12protein level
10 32 13
2013-08-17protein level
10 32 13
2013-07-15protein level
10 16 13
2013-06-11protein level
10 16 13
2013-02-12protein level
10 7 195
2012-12-20protein level
10 7 195
2012-10-30protein level
10 11 195
2012-10-07protein level
10 11 20
2012-08-24protein level
10 7 20
2012-07-28protein level
10 7 20
2012-06-08protein level
10 9 20
2012-05-07protein level
10 9 20
2012-04-10protein level
10 9 20
2012-01-13protein level
10 7 20
2011-12-20protein level
10 7 20
2011-11-11protein level
10 7 19
2011-08-23protein level
9 7 19
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13557-1
0 17 7 56333.3944
NX_Q13557-10
0 17 7 55624.0704
NX_Q13557-11
1 17 7 59113.7561
NX_Q13557-12
1 15 7 54079.2802
NX_Q13557-3
0 17 7 57583.0178
NX_Q13557-4
0 18 7 58434.5413
NX_Q13557-5
0 17 7 56194.479
NX_Q13557-6
0 18 7 57864.1327
NX_Q13557-8
0 16 7 54093.3321
NX_Q13557-9
0 16 7 55342.9555
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-351018,EBI-431907 TNPO2  
  .intracellular protein transport .nuclear localization sequence binding .cytoplasm
.nucleus
2 EBI-351018,EBI-742362 DNAL4  
  .neurotrophin TRK receptor signaling pathway
.microtubule-based process
.motor activity .dynein complex
.cilium
.plasma membrane
  + 2 more...
3 EBI-351018,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
4 EBI-351018,EBI-6693977 FKBP1B  
  .cell communication by electrical coupling involved in cardiac conduction
.calcium ion transmembrane transport
.negative regulation of insulin secretion involved in cellular response to glucose stimulus
  + 27 more...
.ion channel binding
.cyclic nucleotide binding
.calcium channel inhibitor activity
  + 3 more...
.calcium channel complex
.sarcoplasmic reticulum membrane
.Z disc
  + 3 more...
5 EBI-351018,EBI-726858 SCN5A  
  .regulation of sodium ion transmembrane transport
.regulation of heart rate by cardiac conduction
.AV node cell to bundle of His cell communication
  + 33 more...
.scaffold protein binding
.voltage-gated sodium channel activity involved in SA node cell action potential
.voltage-gated sodium channel activity involved in Purkinje myocyte action potential
  + 12 more...
.sarcolemma
.T-tubule
.lateral plasma membrane
  + 7 more...
6 EBI-351018,EBI-10242151 FNDC3B  
  .N/A .poly(A) RNA binding .integral component of membrane
7 EBI-351018,EBI-10244652 EPHA10  
  .ephrin receptor signaling pathway
.axon guidance
.ATP binding
.transmembrane-ephrin receptor activity
.ephrin receptor activity
.extracellular exosome
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
8 EBI-351018,EBI-9526213 TTC5  
  .positive regulation of transcription from RNA polymerase II promoter
.DNA repair
.chromatin binding
.DNA binding
.cytoplasm
.nucleoplasm
9 EBI-351018,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
10 EBI-351018,EBI-739825 MOAP1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.apoptotic signaling pathway
.positive regulation of release of cytochrome c from mitochondria
  + 4 more...
.ubiquitin protein ligase binding .cytosol
.mitochondrial outer membrane
.mitochondrion
.cytoplasm
11 EBI-351018,EBI-5453723 MRPL11  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder33
blood32
bone195
bone marrow41
brain64
connective tissue67
ear186
embryonic tissue28
eye33
heart167
intestine73
kidney47
liver24
lung47
lymph22
lymph node423
mammary gland39
muscle808
ovary9
pancreas42
parathyroid242
placenta3
prostate21
skin42
stomach20
testis57
uterus17
Health State
TissuesTPM*
normal96
bladder carcinoma113
breast (mammary gland) tumor10
chondrosarcoma156
colorectal tumor133
gastrointestinal tumor33
germ cell tumor64
glioma37
kidney tumor29
leukemia95
liver tumor31
lymphoma96
non-neoplasia51
pancreatic tumor9
prostate cancer9
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult90
embryoid body14
blastocyst16
neonate64
fetus105
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.6
adrenal gland27.4
appendix31.1
bone marrow4.3
cerebral cortex59.7
colon39.7
duodenum28.9
esophagus34.5
gallbladder37.5
heart muscle129.3
kidney16.2
liver20.6
lung23.4
lymph node37.6
ovary26.6
pancreas7.3
placenta16.2
prostate31.2
salivary gland10.7
skin12.1
small intestine34.4
spleen18.2
stomach37.8
testis24
thyroid gland28.1
urinary bladder30.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607708, gene) Calcium/calmodulin-dependent protein kinase ii-delta; CAMK2DOMIM


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