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> Protein (NX_Q13561)
Protein (NX_Q13561)
Protein
Gene SymbolDCTN2 to neXtProt (NX_Q13561)
DescriptionDynactin subunit 2
Chromosome12
Location12q13.3 (57923885 ~ 57941114) to Ensembl
Sequene Features : Isoforms 3, Variants 44, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.melanosome transport
.antigen processing and presentation of exogenous peptide antigen via MHC class II
.cell proliferation
  + 5 more...
.spectrin binding
.motor activity
.extracellular exosome
.vesicle
.growth cone
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 44 8
2014-09-19protein level
3 33 8
2014-05-27protein level
3 33 8
2014-02-25protein level
3 33 8
2013-12-09protein level
3 25 8
2013-11-01protein level
3 25 6
2013-09-12protein level
3 25 6
2013-08-17protein level
3 25 6
2013-07-15protein level
3 15 5
2013-06-11protein level
3 15 5
2013-02-12protein level
3 11 9
2012-12-20protein level
3 8 9
2012-10-30protein level
3 11 9
2012-10-07protein level
3 11 3
2012-08-24protein level
3 5 3
2012-07-28protein level
3 5 3
2012-06-08protein level
3 5 3
2012-05-07protein level
3 5 3
2012-04-10protein level
3 5 3
2012-01-13protein level
3 6 3
2011-12-20protein level
3 6 3
2011-11-11protein level
3 6 3
2011-08-23protein level
3 6 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13561-1
1 17 0 44203.7286
NX_Q13561-2
1 17 0 44792.0178
NX_Q13561-3
1 17 0 44445.8546
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-715074,EBI-2548868 CCDC172  
  .N/A .N/A .N/A
2 EBI-715074,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
3 EBI-715074,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
4 EBI-715074,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
5 EBI-715074,EBI-529989 DISC1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of synapse maturation
.canonical Wnt signaling pathway
  + 10 more...
.N/A .postsynaptic membrane
.ciliary basal body
.cell junction
  + 4 more...
6 EBI-715074,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland455
ascites225
bladder100
blood179
bone181
bone marrow61
brain299
cervix412
connective tissue167
ear62
embryonic tissue211
esophagus347
eye186
heart368
intestine267
kidney218
larynx42
liver185
lung218
lymph383
lymph node122
mammary gland158
mouth105
muscle159
nerve128
ovary266
pancreas107
pharynx49
pituitary gland302
placenta215
prostate211
salivary gland246
skin227
spleen187
stomach125
testis176
thymus112
thyroid150
trachea19
umbilical cord508
uterus262
vascular193
Health State
TissuesTPM*
normal220
adrenal tumor474
bladder carcinoma56
breast (mammary gland) tumor161
cervical tumor463
chondrosarcoma217
colorectal tumor151
esophageal tumor347
gastrointestinal tumor194
germ cell tumor216
glioma251
head and neck tumor119
kidney tumor232
leukemia190
liver tumor249
lung tumor262
lymphoma263
non-neoplasia362
ovarian tumor315
pancreatic tumor152
primitive neuroectodermal tumor of the CNS629
prostate cancer260
retinoblastoma215
skin tumor239
soft tissue/muscle tissue tumor159
uterine tumor244
Developmental Stage
TissuesTPM*
adult181
embryoid body142
blastocyst260
neonate386
fetus197
infant765
juvenile215
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue80.1
adrenal gland86.4
appendix63
bone marrow58.7
cerebral cortex88.9
colon98.9
duodenum64.8
esophagus98.9
gallbladder68.6
heart muscle83.9
kidney65.8
liver33.4
lung71.1
lymph node61.2
ovary84
pancreas58.3
placenta64.5
prostate71.9
salivary gland80.6
skin87.1
small intestine79.9
spleen62.4
stomach80.5
testis69.3
thyroid gland77.8
urinary bladder75
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungLow
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607376, gene) Dynactin 2; DCTN2OMIM


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