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> Protein (NX_Q13563)
Protein (NX_Q13563)
Protein
Gene SymbolPKD2 to neXtProt (NX_Q13563)
DescriptionPolycystin-2
Chromosome4
Location4q22.1 (88928820 ~ 88998929) to Ensembl
Sequene Features : Isoforms 5, Variants 111, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of G1/S transition of mitotic cell cycle
.regulation of calcium ion import
.metanephric S-shaped body morphogenesis
  + 45 more...
.phosphoprotein binding
.ATPase binding
.calcium-induced calcium release activity
  + 13 more...
.mitotic spindle
.integral component of lumenal side of endoplasmic reticulum membrane
.integral component of cytoplasmic side of endoplasmic reticulum membrane
  + 16 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 111 7
2014-09-19protein level
5 92 7
2014-05-27protein level
5 92 7
2014-02-25protein level
5 92 7
2013-12-09protein level
5 79 7
2013-11-01protein level
5 75 7
2013-09-12protein level
5 75 7
2013-08-17protein level
5 75 7
2013-07-15protein level
5 57 7
2013-06-11protein level
5 57 7
2013-02-12protein level
5 40 53
2012-12-20protein level
5 40 53
2012-10-30protein level
5 42 53
2012-10-07protein level
5 42 12
2012-08-24protein level
5 42 12
2012-07-28protein level
5 42 12
2012-06-08protein level
5 29 12
2012-05-07protein level
5 29 12
2012-04-10protein level
5 29 12
2012-01-13protein level
1 31 12
2011-12-20protein level
1 31 12
2011-11-11protein level
1 31 12
2011-08-23protein level
1 31 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13563-1
0 41 0 109621.7236
NX_Q13563-2
1 23 0 53651.5827
NX_Q13563-3
1 39 0 103068.3111
NX_Q13563-4
1 27 0 73123.6015
NX_Q13563-5
0 36 0 98774.8768
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7813714,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
2 EBI-7813714,EBI-10182930 MAGEA8  
  .N/A .N/A .N/A
3 EBI-7813714,EBI-929665 TRPC1  
  .calcium ion transmembrane transport
.transmembrane transport
.response to calcium ion
  + 8 more...
.inositol 1,4,5 trisphosphate binding
.ion channel binding
.store-operated calcium channel activity
  + 2 more...
.membrane raft
.receptor complex
.costamere
  + 4 more...
4 EBI-7813714,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
5 EBI-7813714,EBI-1752013 PKD1  
  .metanephric distal tubule morphogenesis
.metanephric proximal tubule development
.metanephric ascending thin limb development
  + 39 more...
.ion channel binding
.carbohydrate binding
.protein domain specific binding
  + 2 more...
.primary cilium
.extracellular exosome
.ciliary membrane
  + 12 more...
6 EBI-7813714,EBI-713450 ID2  
  .negative regulation of neural precursor cell proliferation
.regulation of G1/S transition of mitotic cell cycle
.cellular senescence
  + 43 more...
.ion channel binding .protein complex
.microtubule cytoskeleton
.cytosol
  + 5 more...
7 EBI-7813714,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
bone41
bone marrow20
brain21
connective tissue26
ear124
embryonic tissue70
eye28
heart22
kidney37
larynx42
liver24
lung53
lymph node55
mammary gland46
mouth15
muscle28
ovary9
pancreas74
parathyroid48
pituitary gland60
placenta10
prostate21
skin23
stomach31
testis6
thymus12
tonsil58
umbilical cord72
uterus68
vascular58
Health State
TissuesTPM*
normal37
breast (mammary gland) tumor32
chondrosarcoma72
gastrointestinal tumor33
germ cell tumor15
glioma9
head and neck tumor7
kidney tumor29
leukemia10
liver tumor20
lung tumor29
non-neoplasia62
pancreatic tumor66
primitive neuroectodermal tumor of the CNS7
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult24
embryoid body85
blastocyst65
neonate32
fetus48
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.5
adrenal gland23.8
appendix14.3
bone marrow8.6
cerebral cortex10.6
colon11.2
duodenum10.4
esophagus12.5
gallbladder29
heart muscle16.1
kidney41.4
liver8.3
lung22.6
lymph node11.3
ovary45.9
pancreas6.5
placenta19.6
prostate20
salivary gland6
skin9
small intestine10.9
spleen10.6
stomach8.3
testis11.8
thyroid gland16.2
urinary bladder21.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*173910, gene) Polycystin 2; PKD2OMIM
2(#613095, phenotype) Polycystic kidney disease 2; PKD2OMIM


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