Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q13568)
Protein (NX_Q13568)
Protein
Gene SymbolIRF5 to neXtProt (NX_Q13568)
DescriptionInterferon regulatory factor 5
Chromosome7
Location7q32.1 (128577666 ~ 128590089) to Ensembl
Sequene Features : Isoforms 6, Variants 52, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
.defense response to virus
  + 9 more...
.sequence-specific DNA binding transcription factor activity
.regulatory region DNA binding
.cytosol
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 52 10
2014-09-19protein level
6 36 10
2014-05-27protein level
6 36 10
2014-02-25protein level
6 36 10
2013-12-09protein level
6 23 10
2013-11-01protein level
6 20 10
2013-09-12protein level
5 21 10
2013-08-17protein level
5 21 10
2013-07-15protein level
5 9 10
2013-06-11protein level
5 9 10
2013-02-12protein level
5 4 50
2012-12-20protein level
4 4 40
2012-10-30protein level
4 4 40
2012-10-07protein level
4 4 10
2012-08-24protein level
4 4 10
2012-07-28protein level
4 4 10
2012-06-08protein level
4 4 10
2012-05-07protein level
2 4 1
2012-04-10protein level
2 4 1
2012-01-13protein level
2 4 1
2011-12-20protein level
2 4 1
2011-11-11protein level
2 4 1
2011-08-23protein level
2 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13568-1
0 22 0 56008.3902
NX_Q13568-2
0 22 0 57733.241
NX_Q13568-3
0 22 0 56632.6101
NX_Q13568-4
0 22 0 54907.7593
NX_Q13568-5
1 19 0 47004.5458
NX_Q13568-6
2 5 0 17008.739
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3931258,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-3931258,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
3 EBI-3931258,EBI-995373 MAVS  
  .regulation of peroxisome organization
.positive regulation of IP-10 production
.positive regulation of chemokine (C-C motif) ligand 5 production
  + 22 more...
.CARD domain binding
.protein kinase binding
.signal transducer activity
.mitochondrial membrane
.integral component of membrane
.peroxisomal membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood114
bone13
bone marrow20
brain20
connective tissue40
eye4
intestine21
kidney61
lung20
lymph node155
mammary gland13
mouth15
pancreas42
placenta14
prostate5
spleen56
stomach10
testis2
thymus87
trachea19
uterus17
Health State
TissuesTPM*
normal23
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma36
colorectal tumor26
germ cell tumor7
glioma65
head and neck tumor7
kidney tumor87
leukemia31
lung tumor19
lymphoma41
non-neoplasia31
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult11
neonate225
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.9
adrenal gland4.8
appendix13.5
bone marrow15.5
cerebral cortex3.3
colon5
duodenum8
esophagus9.2
gallbladder7.3
heart muscle1.7
kidney10
liver2.4
lung10.7
lymph node21.6
ovary1.5
pancreas2.7
placenta5.3
prostate2.7
salivary gland3.8
skin9.4
small intestine9.2
spleen25.4
stomach6.2
testis2
thyroid gland2.1
urinary bladder11.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#180300, phenotype) Rheumatoid arthritis; RAOMIM
2(*607218, gene) Interferon regulatory factor 5; IRF5OMIM
3(#612245, phenotype) Inflammatory bowel disease 14; IBD14OMIM
4(#612251, phenotype) Systemic lupus erythematosus, susceptibility to, 10; SLEB10OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center