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> Protein (NX_Q13573)
Protein (NX_Q13573)
Protein
Gene SymbolSNW1 to neXtProt (NX_Q13573)
DescriptionSNW domain-containing protein 1
Chromosome14
Location14q24.3 (78183942 ~ 78227550) to Ensembl
Sequene Features : Isoforms 1, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 45 9
2014-09-19protein level
1 35 9
2014-05-27protein level
1 35 9
2014-02-25protein level
1 36 8
2013-12-09protein level
1 32 8
2013-11-01protein level
1 32 8
2013-09-12protein level
1 32 8
2013-08-17protein level
1 32 8
2013-07-15protein level
1 20 6
2013-06-11protein level
1 20 6
2013-02-12protein level
1 8 6
2012-12-20protein level
1 8 6
2012-10-30protein level
1 8 6
2012-10-07protein level
1 8 6
2012-08-24protein level
1 2 6
2012-07-28protein level
1 2 6
2012-06-08protein level
1 2 6
2012-05-07protein level
1 2 6
2012-04-10protein level
1 2 6
2012-01-13protein level
1 4 6
2011-12-20protein level
1 4 6
2011-11-11protein level
1 4 5
2011-08-23protein level
1 4 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13573-1
21 0 0 61456.3026
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-632715,EBI-372721 FOXN3  
  .negative regulation of transcription, DNA-templated
.mitotic G2 DNA damage checkpoint
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.nucleus
2 EBI-632715,EBI-607761 SART1  
  .intrinsic apoptotic signaling pathway
.positive regulation of cytotoxic T cell differentiation
.mRNA cis splicing, via spliceosome
  + 4 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.U4/U6 x U5 tri-snRNP complex
.Cajal body
  + 4 more...
3 EBI-632715,EBI-352682 HSPB1  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.platelet aggregation
  + 17 more...
.poly(A) RNA binding
.ubiquitin binding
.identical protein binding
  + 3 more...
.extracellular exosome
.Z disc
.focal adhesion
  + 8 more...
4 EBI-632715,EBI-286357 VDR  
  .vitamin D receptor signaling pathway
.mammary gland branching involved in pregnancy
.regulation of calcidiol 1-monooxygenase activity
  + 20 more...
.lithocholic acid binding
.calcitriol binding
.retinoid X receptor binding
  + 6 more...
.RNA polymerase II transcription factor complex
.receptor complex
.nucleoplasm
.nucleus
5 EBI-632715,EBI-742339 U2AF2  
  .negative regulation of mRNA splicing, via spliceosome
.positive regulation of RNA splicing
.mRNA 3'-end processing
  + 7 more...
.poly(A) RNA binding
.enzyme binding
.nucleotide binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
6 EBI-632715,EBI-740978 MAGEA1  
  .negative regulation of Notch signaling pathway
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.histone deacetylase binding .plasma membrane
.cytoplasm
.nucleus
7 EBI-632715,EBI-636374 NOTCH1  
  .negative regulation of endothelial cell chemotaxis
.negative regulation of pro-B cell differentiation
.negative regulation of anoikis
  + 125 more...
.sequence-specific DNA binding
.chromatin DNA binding
.enzyme binding
  + 6 more...
.receptor complex
.integral component of membrane
.cell surface
  + 9 more...
8 EBI-632715,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
9 EBI-632715,EBI-632552 RBPJ  
  .positive regulation of cell proliferation involved in heart morphogenesis
.positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
.positive regulation of ephrin receptor signaling pathway
  + 46 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 7 more...
.cytoplasm
.nucleolus
.transcription factor complex
  + 3 more...
10 EBI-632715,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
11 EBI-632715,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
12 EBI-632715,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
13 EBI-632715,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
14 EBI-632715,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
15 EBI-632715,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
16 EBI-632715,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
17 EBI-632715,EBI-1226435 PABPN1  
  .modification by virus of host mRNA processing
.mRNA 3'-end processing
.viral life cycle
  + 10 more...
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.ribonucleoprotein complex
.cytoplasm
.nucleoplasm
.nucleus
18 EBI-632715,EBI-742397 TEX11  
  .chiasma assembly
.negative regulation of apoptotic process
.fertilization
  + 6 more...
.N/A .central element
19 EBI-632715,EBI-749336 SNIP1  
  .positive regulation of protein targeting to mitochondrion
.production of miRNAs involved in gene silencing by miRNA
.I-kappaB kinase/NF-kappaB signaling
.regulation of transcription, DNA-templated
.poly(A) RNA binding .cytoplasm
.nucleoplasm
20 EBI-632715,EBI-748128 CTNNBL1  
  .positive regulation of apoptotic process
.somatic diversification of immunoglobulins
.gene expression
  + 3 more...
.enzyme binding .membrane
.cytoplasm
.spliceosomal complex
  + 3 more...
21 EBI-632715,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
22 EBI-632715,EBI-3920997 ZNF830  
  .intestinal epithelial structure maintenance
.cell division
.chromosome organization
  + 4 more...
.metal ion binding .nuclear speck
.cytoplasm
.nucleoplasm
23 EBI-632715,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
24 EBI-632715,EBI-295232 XAB2  
  .transcription, DNA-templated
.nucleotide-excision repair
.transcription-coupled nucleotide-excision repair
  + 3 more...
.N/A .catalytic step 2 spliceosome
.membrane
.nucleoplasm
.nucleus
25 EBI-632715,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
26 EBI-632715,EBI-352039 THRAP3  
  .rhythmic process
.mRNA stabilization
.positive regulation of mRNA splicing, via spliceosome
  + 10 more...
.phosphoprotein binding
.thyroid hormone receptor binding
.poly(A) RNA binding
  + 8 more...
.extracellular exosome
.mediator complex
.nucleoplasm
.nucleus
27 EBI-632715,EBI-2557649 PPIL1  
  .protein folding
.protein peptidyl-prolyl isomerization
.mRNA splicing, via spliceosome
.peptidyl-prolyl cis-trans isomerase activity .catalytic step 2 spliceosome
.extracellular exosome
28 EBI-632715,EBI-80830 NCOR2  
  .regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
.small molecule metabolic process
.cellular lipid metabolic process
  + 7 more...
.protein N-terminus binding
.histone deacetylase binding
.Notch binding
  + 3 more...
.transcriptional repressor complex
.nuclear body
.nuclear matrix
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland242
ascites150
bladder100
blood212
bone111
bone marrow307
brain118
cervix247
connective tissue80
ear248
embryonic tissue84
esophagus545
eye71
heart134
intestine81
kidney142
liver165
lung95
lymph270
lymph node33
mammary gland105
mouth15
muscle122
ovary137
pancreas60
parathyroid97
pharynx147
pituitary gland60
placenta77
prostate68
skin94
spleen206
stomach31
testis151
thymus175
thyroid85
tonsil58
trachea77
umbilical cord145
uterus124
vascular193
Health State
TissuesTPM*
normal109
adrenal tumor79
breast (mammary gland) tumor85
cervical tumor144
chondrosarcoma60
colorectal tumor44
esophageal tumor463
gastrointestinal tumor92
germ cell tumor136
glioma83
kidney tumor87
leukemia254
liver tumor208
lung tumor87
lymphoma221
non-neoplasia82
ovarian tumor170
pancreatic tumor104
primitive neuroectodermal tumor of the CNS259
prostate cancer67
retinoblastoma172
skin tumor119
soft tissue/muscle tissue tumor87
uterine tumor144
Developmental Stage
TissuesTPM*
adult82
embryoid body57
blastocyst65
neonate96
fetus131
infant382
juvenile395
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.1
adrenal gland35.5
appendix40.1
bone marrow70.4
cerebral cortex27.9
colon36.8
duodenum31
esophagus35.5
gallbladder34.4
heart muscle36
kidney28.9
liver23.4
lung35
lymph node49.2
ovary48.5
pancreas18.4
placenta45.8
prostate30.9
salivary gland22.8
skin40.9
small intestine32.2
spleen39.2
stomach32.9
testis54.2
thyroid gland42.6
urinary bladder43.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603055, gene) Ski-interacting protein; SKIIPOMIM


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