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> Protein (NX_Q13596)
Protein (NX_Q13596)
Protein
Gene SymbolSNX1 to neXtProt (NX_Q13596)
DescriptionSorting nexin-1
Chromosome15
Location15q22.31 (64386322 ~ 64438289) to Ensembl
Sequene Features : Isoforms 3, Variants 52, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.lamellipodium morphogenesis
.positive regulation of protein catabolic process
.retrograde transport, endosome to Golgi
  + 4 more...
.leptin receptor binding
.transferrin receptor binding
.identical protein binding
  + 3 more...
.protein complex
.intracellular membrane-bounded organelle
.early endosome membrane
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 52 6
2014-09-19protein level
3 43 6
2014-05-27protein level
3 43 6
2014-02-25protein level
3 42 6
2013-12-09protein level
3 29 6
2013-11-01protein level
3 27 6
2013-09-12protein level
3 27 6
2013-08-17protein level
3 27 6
2013-07-15protein level
3 15 5
2013-06-11protein level
3 15 5
2013-02-12protein level
3 8 15
2012-12-20protein level
2 6 10
2012-10-30protein level
2 9 10
2012-10-07protein level
2 9 5
2012-08-24protein level
2 9 5
2012-07-28protein level
2 9 5
2012-06-08protein level
2 13 5
2012-05-07protein level
2 11 5
2012-04-10protein level
2 11 5
2012-01-13protein level
2 8 5
2011-12-20protein level
2 8 5
2011-11-11protein level
2 8 5
2011-08-23protein level
2 8 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13596-1
0 22 2 59032.9142
NX_Q13596-2
1 19 2 51780.3505
NX_Q13596-3
3 21 1 63043.0574
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2822329,EBI-740467 RTN3  
  .endoplasmic reticulum tubular network organization
.vesicle-mediated transport
.viral process
.apoptotic process
.N/A .extracellular exosome
.integral component of membrane
.endoplasmic reticulum membrane
  + 3 more...
2 EBI-2822329,EBI-714543 ARL6IP1  
  .cotranslational protein targeting to membrane .N/A .integral component of membrane
.membrane
.cytosol
.Sec61 translocon complex
3 EBI-2822329,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
4 EBI-2822329,EBI-8099743 SNX32  
  .vesicle organization
.protein transport
.endocytosis
.phosphatidylinositol binding .extrinsic component of membrane
.endosome
5 EBI-2822329,EBI-3059266 FUNDC1  
  .response to hypoxia
.mitochondrion degradation
.N/A .integral component of mitochondrial outer membrane
.mitochondrial outer membrane
6 EBI-2822329,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
7 EBI-2822329,EBI-750345 REEP6  
  .regulation of intracellular transport .N/A .apical part of cell
.rod spherule
.integral component of membrane
  + 2 more...
8 EBI-2822329,EBI-1054634 VPS35  
  .retrograde transport, endosome to plasma membrane
.negative regulation of late endosome to lysosome transport
.transcytosis
  + 2 more...
.protein transporter activity .tubular endosome
.extracellular exosome
.retromer complex
  + 5 more...
9 EBI-2822329,EBI-715945 RTN4  
  .regulation of branching morphogenesis of a nerve
.endoplasmic reticulum tubular network organization
.cardiac epithelial to mesenchymal transition
  + 11 more...
.poly(A) RNA binding .extracellular exosome
.neuronal cell body
.cell projection
  + 5 more...
10 EBI-2822329,EBI-712367 RABAC1  
  .N/A .identical protein binding .cell junction
.integral component of membrane
.membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland60
bladder133
blood179
bone83
bone marrow20
brain109
cervix185
connective tissue53
embryonic tissue51
esophagus248
eye81
heart100
intestine90
kidney42
larynx255
liver77
lung71
lymph22
lymph node189
mammary gland330
mouth45
muscle300
nerve193
ovary49
pancreas145
parathyroid48
pharynx24
pituitary gland121
placenta63
prostate73
skin75
spleen18
stomach62
testis68
thymus112
thyroid343
tonsil58
trachea77
umbilical cord145
uterus133
vascular38
Health State
TissuesTPM*
normal98
adrenal tumor158
breast (mammary gland) tumor386
cervical tumor231
chondrosarcoma72
colorectal tumor106
esophageal tumor289
gastrointestinal tumor50
germ cell tumor68
glioma93
head and neck tumor134
kidney tumor72
leukemia190
liver tumor83
lung tumor58
lymphoma69
non-neoplasia134
ovarian tumor26
pancreatic tumor47
primitive neuroectodermal tumor of the CNS94
prostate cancer96
retinoblastoma21
skin tumor55
soft tissue/muscle tissue tumor135
uterine tumor155
Developmental Stage
TissuesTPM*
adult128
embryoid body28
blastocyst81
neonate96
fetus64
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue53.7
adrenal gland60.2
appendix62.7
bone marrow25.3
cerebral cortex40
colon49.9
duodenum48.9
esophagus60.9
gallbladder54.7
heart muscle46.3
kidney55.4
liver38.1
lung60
lymph node70.5
ovary47.5
pancreas22.3
placenta58.1
prostate59.3
salivary gland44
skin47.8
small intestine52.8
spleen60.4
stomach43.9
testis42.3
thyroid gland115.4
urinary bladder74.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderMedium
kidneyMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleHigh
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
stomach 1Medium
testisLow
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601272, gene) Sorting nexin 1; SNX1OMIM


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