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> Protein (NX_Q13608)
Protein (NX_Q13608)
Protein
Gene SymbolPEX6 to neXtProt (NX_Q13608)
DescriptionPeroxisome assembly factor 2
Chromosome6
Location6p21.1 (42931608 ~ 42946958) to Ensembl
Sequene Features : Isoforms 3, Variants 109, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein stabilization
.protein import into peroxisome matrix, translocation
.metabolic process
  + 2 more...
.ATPase activity, coupled
.protein complex binding
.ATPase activity
  + 2 more...
.cytosol
.peroxisomal membrane
.peroxisome
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 109 2
2014-09-19protein level
1 77 2
2014-05-27protein level
1 77 2
2014-02-25protein level
1 77 2
2013-12-09protein level
1 55 2
2013-11-01protein level
1 54 2
2013-09-12protein level
1 54 2
2013-08-17protein level
1 54 2
2013-07-15protein level
1 42 0
2013-06-11protein level
1 42 0
2013-02-12protein level
1 32 0
2012-12-20protein level
1 28 0
2012-10-30protein level
1 33 0
2012-10-07protein level
1 33 0
2012-08-24protein level
1 30 0
2012-07-28protein level
1 30 0
2012-06-08protein level
1 31 0
2012-05-07protein level
1 31 0
2012-04-10protein level
1 31 0
2012-01-13protein level
1 29 0
2011-12-20protein level
1 29 0
2011-11-11protein level
1 29 0
2011-08-23protein level
1 29 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13608-1
0 37 0 103995.4635
NX_Q13608-2
1 25 0 77693.6371
NX_Q13608-3
1 33 0 94511.6296
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-988581,EBI-988601 PEX1  
  .microtubule-based peroxisome localization
.protein import into peroxisome matrix
.metabolic process
  + 2 more...
.ATPase activity, coupled
.protein complex binding
.protein C-terminus binding
.ATP binding
.extracellular exosome
.intracellular membrane-bounded organelle
.cytosol
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland30
ascites25
blood57
bone27
bone marrow102
brain43
cervix144
connective tissue26
embryonic tissue42
eye33
heart33
intestine4
kidney14
liver29
lung41
lymph203
lymph node55
mammary gland13
mouth105
muscle18
ovary19
pancreas42
placenta21
prostate26
skin9
testis39
thymus112
thyroid42
tonsil58
trachea38
uterus47
vascular19
Health State
TissuesTPM*
normal35
breast (mammary gland) tumor10
cervical tumor115
chondrosarcoma48
gastrointestinal tumor8
germ cell tumor41
glioma74
head and neck tumor52
kidney tumor29
leukemia52
liver tumor41
lung tumor29
lymphoma124
non-neoplasia41
pancreatic tumor28
primitive neuroectodermal tumor of the CNS31
prostate cancer9
skin tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult28
embryoid body85
blastocyst48
fetus32
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.4
adrenal gland10.7
appendix7.1
bone marrow4.6
cerebral cortex8.6
colon9.7
duodenum7
esophagus7.8
gallbladder8.9
heart muscle6.7
kidney11.9
liver6
lung6.4
lymph node10.8
ovary13.5
pancreas9
placenta8.4
prostate13
salivary gland9.4
skin9.3
small intestine9.8
spleen10.9
stomach7.6
testis9.4
thyroid gland11.4
urinary bladder10
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderLow
hippocampusMedium
kidneyMedium
lateral ventricleLow
lungLow
lymph nodeHigh
nasopharynxLow
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skin 1Low
skin 2Medium
small intestineHigh
soft tissue 1Low
spleenHigh
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601498, gene) Peroxisome biogenesis factor 6; PEX6OMIM
2(#614862, phenotype) Peroxisome biogenesis disorder 4a (zellweger); PBD4AOMIM
3(#614863, phenotype) Peroxisome biogenesis disorder 4b; PBD4BOMIM


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