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> Protein (NX_Q13618)
Protein (NX_Q13618)
Protein
Gene SymbolCUL3 to neXtProt (NX_Q13618)
DescriptionCullin-3
Chromosome2
Location2q36.2 (225334867 ~ 225450110) to Ensembl
Sequene Features : Isoforms 3, Variants 102, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intrinsic apoptotic signaling pathway
.negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
  + 22 more...
.POZ domain binding .extracellular exosome
.Cul3-RING ubiquitin ligase complex
.membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 102 11
2014-09-19protein level
3 75 11
2014-05-27protein level
3 75 11
2014-02-25protein level
3 75 11
2013-12-09protein level
3 72 11
2013-11-01protein level
3 66 7
2013-09-12protein level
3 66 7
2013-08-17protein level
3 66 7
2013-07-15protein level
3 39 3
2013-06-11protein level
3 39 3
2013-02-12protein level
3 15 11
2012-12-20protein level
3 16 11
2012-10-30protein level
3 17 11
2012-10-07protein level
3 17 4
2012-08-24protein level
3 9 4
2012-07-28protein level
3 9 4
2012-06-08protein level
3 14 4
2012-05-07protein level
3 12 4
2012-04-10protein level
3 10 4
2012-01-13protein level
3 8 4
2011-12-20protein level
3 8 4
2011-11-11protein level
3 8 4
2011-08-23protein level
3 8 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13618-1
1 38 0 88873.2004
NX_Q13618-2
0 38 0 86178.8204
NX_Q13618-3
0 33 0 81041.2158
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-456129,EBI-743549 SPOP  
  .positive regulation of type B pancreatic cell apoptotic process
.positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin protein ligase binding .Cul3-RING ubiquitin ligase complex
.nuclear speck
.nucleoplasm
.nucleus
2 EBI-456129,EBI-3943153 CCDC22  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 4 more...
.cullin family protein binding .endosome
3 EBI-456129,EBI-746999 KLHL2  
  .protein ubiquitination .actin binding .Cul3-RING ubiquitin ligase complex
.lamellipodium
.actin cytoskeleton
  + 3 more...
4 EBI-456129,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
5 EBI-456129,EBI-495373 TNFSF10  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.programmed necrotic cell death
  + 18 more...
.metal ion binding
.receptor binding
.extracellular exosome
.integral component of plasma membrane
.extracellular space
.extracellular region
6 EBI-456129,EBI-2505861 TNFAIP1  
  .protein homooligomerization
.positive regulation of DNA replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 8 more...
.GTP-Rho binding .Cul3-RING ubiquitin ligase complex
.endosome
.cytoplasm
.nucleolus
7 EBI-456129,EBI-78060 CASP8  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 55 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cysteine-type endopeptidase activity involved in apoptotic process
.scaffold protein binding
  + 5 more...
.ripoptosome
.membrane raft
.cell body
  + 11 more...
8 EBI-456129,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
9 EBI-456129,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
10 EBI-456129,EBI-456077 CAND1  
  .positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
.negative regulation of catalytic activity
.cell differentiation
  + 2 more...
.N/A .extracellular exosome
.cullin-RING ubiquitin ligase complex
.membrane
  + 4 more...
11 EBI-456129,EBI-6153160 KLHL7  
  .protein ubiquitination .protein homodimerization activity
.identical protein binding
.Cul3-RING ubiquitin ligase complex
.plasma membrane
.cytoplasm
  + 3 more...
12 EBI-456129,EBI-2511344 KCTD6  
  .protein homooligomerization .ankyrin binding .N/A
13 EBI-456129,EBI-742916 KCTD13  
  .protein homooligomerization
.positive regulation of DNA replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 5 more...
.GTP-Rho binding .Cul3-RING ubiquitin ligase complex
.nucleoplasm
.nucleus
14 EBI-456129,EBI-7223971 ABTB1  
  .N/A .translation elongation factor activity .plasma membrane
.cytoplasm
.nucleolus
15 EBI-456129,EBI-2548542 ZMAT4  
  .N/A .zinc ion binding
.DNA binding
.nucleus
16 EBI-456129,EBI-714379 KLHL20  
  .protein K33-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
.negative regulation of apoptotic process
  + 5 more...
.interferon-gamma binding
.ubiquitin-protein transferase activity
.perinuclear region of cytoplasm
.Cul3-RING ubiquitin ligase complex
.dendrite
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites100
bladder66
blood57
bone55
bone marrow61
brain52
cervix82
connective tissue80
embryonic tissue79
esophagus99
eye86
heart55
intestine86
kidney113
liver77
lung56
lymph node167
mammary gland72
mouth30
muscle47
ovary39
pancreas70
parathyroid291
pharynx171
pituitary gland60
placenta56
prostate58
skin61
spleen74
stomach73
testis142
thymus12
thyroid21
trachea19
uterus64
vascular116
Health State
TissuesTPM*
normal79
adrenal tumor79
breast (mammary gland) tumor53
cervical tumor115
chondrosarcoma156
colorectal tumor62
esophageal tumor115
gastrointestinal tumor84
germ cell tumor72
glioma102
head and neck tumor82
kidney tumor29
leukemia74
liver tumor72
lung tumor9
lymphoma41
non-neoplasia51
ovarian tumor52
pancreatic tumor76
primitive neuroectodermal tumor of the CNS39
prostate cancer38
skin tumor55
soft tissue/muscle tissue tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult77
embryoid body57
blastocyst48
fetus78
infant85
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.3
adrenal gland36.7
appendix39
bone marrow36.8
cerebral cortex34.1
colon38.4
duodenum32.8
esophagus52.8
gallbladder34.2
heart muscle31
kidney39.9
liver25.5
lung30.4
lymph node55
ovary31.4
pancreas16.4
placenta36.7
prostate31.9
salivary gland27.4
skin44.6
small intestine32
spleen29.2
stomach32.8
testis184.4
thyroid gland46
urinary bladder40.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603136, gene) Cullin 3; CUL3OMIM
2(#614496, phenotype) Pseudohypoaldosteronism, type iie; PHA2EOMIM


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