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> Protein (NX_Q13625)
Protein (NX_Q13625)
Protein
Gene SymbolTP53BP2 to neXtProt (NX_Q13625)
DescriptionApoptosis-stimulating of p53 protein 2
Chromosome1
Location1q41 (223967601 ~ 224033674) to Ensembl
Sequene Features : Isoforms 3, Variants 134, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 134 14
2014-09-19protein level
3 99 14
2014-05-27protein level
3 99 15
2014-02-25protein level
3 96 15
2013-12-09protein level
3 66 15
2013-11-01protein level
3 64 15
2013-09-12protein level
3 64 14
2013-08-17protein level
3 64 14
2013-07-15protein level
3 38 11
2013-06-11protein level
3 38 11
2013-02-12protein level
3 22 24
2012-12-20protein level
3 22 24
2012-10-30protein level
3 31 24
2012-10-07protein level
3 31 8
2012-08-24protein level
3 23 8
2012-07-28protein level
3 23 8
2012-06-08protein level
3 24 8
2012-05-07protein level
3 24 8
2012-04-10protein level
2 24 8
2012-01-13protein level
2 12 8
2011-12-20protein level
2 12 8
2011-11-11protein level
2 12 6
2011-08-23protein level
2 12 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13625-1
0 44 1 125537.8788
NX_Q13625-2
0 41 1 111361.9782
NX_Q13625-3
0 44 1 126244.2352
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10175039,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
2 EBI-77642,EBI-1053045 APC2  
  .negative regulation of canonical Wnt signaling pathway
.negative regulation of catenin import into nucleus
.Wnt signaling pathway
.beta-catenin binding .perinuclear region of cytoplasm
.lamellipodium membrane
.catenin complex
  + 6 more...
3 EBI-77642,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
4 EBI-77642,EBI-77613 APP  
  .membrane organization
.smooth endoplasmic reticulum calcium ion homeostasis
.neuron apoptotic process
  + 41 more...
.PTB domain binding
.transition metal ion binding
.identical protein binding
  + 7 more...
.extracellular exosome
.spindle midzone
.perinuclear region of cytoplasm
  + 27 more...
5 EBI-77642,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
6 EBI-10175039,EBI-2841331 ZNF26  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
7 EBI-77642,EBI-356283 PPP1CC  
  .cell division
.small molecule metabolic process
.entrainment of circadian clock by photoperiod
  + 10 more...
.protein N-terminus binding
.metal ion binding
.poly(A) RNA binding
  + 4 more...
.PTW/PP1 phosphatase complex
.MLL5-L complex
.protein complex
  + 11 more...
8 EBI-10175039,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
9 EBI-287091,EBI-1044059 YAP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of stem cell differentiation
.negative regulation of nucleic acid-templated transcription
  + 24 more...
.transcription regulatory region DNA binding
.transcription corepressor activity
.transcription coactivator activity
  + 3 more...
.cell junction
.membrane
.cytosol
  + 4 more...
10 EBI-10175039,EBI-749995 TCL1A  
  .stem cell maintenance
.multicellular organismal development
.N/A .pronucleus
.cell cortex
.endoplasmic reticulum
11 EBI-10175039,EBI-2105393 UBASH3A  
  .negative regulation of T cell receptor signaling pathway
.regulation of cytokine production
.N/A .extracellular exosome
.cytosol
.nucleus
12 EBI-10175039,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
13 EBI-77642,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
14 EBI-10175039,EBI-352350 PPP1CB  
  .cell division
.small molecule metabolic process
.entrainment of circadian clock by photoperiod
  + 13 more...
.myosin-light-chain-phosphatase activity
.metal ion binding
.protein kinase binding
  + 2 more...
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 7 more...
15 EBI-10175039,EBI-354552 HIST1H2BC  
  .defense response to Gram-positive bacterium
.antibacterial humoral response
.nucleosome assembly
  + 2 more...
.DNA binding .extracellular exosome
.nucleoplasm
.nucleus
  + 3 more...
16 EBI-10175039,EBI-359527 POLR2L  
  .positive regulation of viral transcription
.negative regulation of gene expression, epigenetic
.innate immune response
  + 23 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
  + 3 more...
17 EBI-10175039,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
18 EBI-287091,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
19 EBI-77642,EBI-287195 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
20 EBI-77642,EBI-447295 EP300  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.regulation of tubulin deacetylation
  + 40 more...
.pre-mRNA intronic binding
.androgen receptor binding
.nuclear hormone receptor binding
  + 17 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
  + 2 more...
21 EBI-10175039,EBI-10241513 PLEKHN1  
  .N/A .N/A .plasma membrane
22 EBI-10175039,EBI-719994 CCDC92  
  .N/A .N/A .centriole
23 EBI-10175039,EBI-10178410 NUTM1  
  .N/A .N/A .cytoplasm
.nucleus
24 EBI-10175039,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
25 EBI-10175039,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
26 EBI-10175039,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
27 EBI-10175039,EBI-5658424 MTMR14  
  .small molecule metabolic process
.phosphatidylinositol biosynthetic process
.phospholipid metabolic process
.protein tyrosine phosphatase activity
.phosphatidylinositol-3-phosphatase activity
.perinuclear region of cytoplasm
.cytosol
.ruffle
28 EBI-77642,EBI-707714 BCL2L2  
  .negative regulation of intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.Sertoli cell proliferation
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.extracellular exosome
.cytosol
.mitochondrial outer membrane
29 EBI-10175039,EBI-356349 TANK  
  .innate immune response
.TRIF-dependent toll-like receptor signaling pathway
.toll-like receptor 4 signaling pathway
  + 5 more...
.metal ion binding
.ubiquitin protein ligase binding
.cytosol
.cytoplasm
30 EBI-10175039,EBI-746259 OTUB2  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.protein K11-linked deubiquitination
.protein deubiquitination
.ubiquitin-specific protease activity .nucleus
31 EBI-10175039,EBI-740086 DCUN1D1  
  .N/A .N/A .nucleus
.ubiquitin ligase complex
32 EBI-77642,EBI-1564678 ITCH  
  .regulation of protein deubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
  + 21 more...
.ubiquitin protein ligase activity
.CXCR chemokine receptor binding
.ribonucleoprotein complex binding
  + 2 more...
.extracellular exosome
.cytoplasmic vesicle
.membrane
  + 5 more...
33 EBI-10175039,EBI-1018153 HNRNPUL1  
  .gene expression
.response to virus
.RNA splicing
  + 4 more...
.poly(A) RNA binding
.enzyme binding
.RNA binding
.ribonucleoprotein complex
.nucleoplasm
.nucleus
34 EBI-10175039,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
35 EBI-10175039,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
36 EBI-10175039,EBI-398874 NXF1  
  .poly(A)+ mRNA export from nucleus
.viral process
.gene expression
.mRNA export from nucleus
.poly(A) RNA binding
.nucleocytoplasmic transporter activity
.mRNA binding
.nucleotide binding
.nuclear inclusion body
.nuclear speck
.cytosol
  + 2 more...
37 EBI-10175039,EBI-525456 BAIAP2  
  .positive regulation of actin cytoskeleton reorganization
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.proline-rich region binding
.identical protein binding
.cytoskeletal adaptor activity
.protein C-terminus binding
.extracellular exosome
.neuron projection
.filopodium
  + 6 more...
38 EBI-10175039,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder33
blood106
bone27
brain168
connective tissue33
embryonic tissue84
esophagus99
eye47
heart33
intestine17
kidney42
larynx85
liver14
lung35
lymph node55
mammary gland52
mouth45
muscle28
ovary9
pancreas9
parathyroid145
pharynx24
placenta35
prostate42
salivary gland98
skin37
spleen37
stomach31
testis27
thymus37
thyroid42
trachea38
uterus38
vascular38
Health State
TissuesTPM*
normal84
breast (mammary gland) tumor42
chondrosarcoma36
colorectal tumor8
esophageal tumor115
gastrointestinal tumor59
germ cell tumor60
glioma18
head and neck tumor29
kidney tumor43
leukemia63
liver tumor20
lung tumor48
non-neoplasia103
primitive neuroectodermal tumor of the CNS31
prostate cancer19
skin tumor23
soft tissue/muscle tissue tumor39
uterine tumor44
Developmental Stage
TissuesTPM*
adult56
embryoid body142
blastocyst81
fetus64
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.9
adrenal gland9.5
appendix13.5
bone marrow32.1
cerebral cortex27
colon10.7
duodenum7.3
esophagus17
gallbladder21.3
heart muscle9.8
kidney9.3
liver9.7
lung18
lymph node13.6
ovary14.3
pancreas6.5
placenta8.9
prostate8.3
salivary gland8.4
skin9.6
small intestine9
spleen8.9
stomach10.1
testis13.9
thyroid gland19.8
urinary bladder12.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineMedium
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602143, gene) Tumor protein p53-binding protein 2; TP53BP2OMIM


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