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	> Protein (NX_Q13627) Protein (NX_Q13627) Protein Gene Symbol DYRK1A to neXtProt (NX_Q13627) Description Dual specificity tyrosine-phosphorylation-regulated kinase 1A Chromosome 21 Location 21q22.13 (38738092 ~ 38889753) to Ensembl Sequene Features : Isoforms 5, Variants 100, PTMs 13 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .positive regulation of protein deacetylation .protein autophosphorylation .negative regulation of DNA damage response, signal transduction by p53 class mediator   + 8 more... .tau protein binding .protein self-association .ATP binding   + 5 more... .ribonucleoprotein complex .nuclear speck .nucleoplasm .nucleus Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 5 100 13 2014-09-19 protein level 5 82 13 2014-05-27 protein level 5 80 14 2014-02-25 protein level 5 78 7 2013-12-09 protein level 5 60 7 2013-11-01 protein level 5 58 7 2013-09-12 protein level 5 58 7 2013-08-17 protein level 5 58 7 2013-07-15 protein level 5 41 6 2013-06-11 protein level 5 41 6 2013-02-12 protein level 5 15 29 2012-12-20 protein level 5 15 29 2012-10-30 protein level 5 21 29 2012-10-07 protein level 5 21 7 2012-08-24 protein level 5 20 7 2012-07-28 protein level 5 20 7 2012-06-08 protein level 5 29 7 2012-05-07 protein level 5 19 7 2012-04-10 protein level 5 19 7 2012-01-13 protein level 5 16 7 2011-12-20 protein level 5 16 7 2011-11-11 protein level 5 16 8 2011-08-23 protein level 5 16 8 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q13627-1 0 24 6 85529.7405 NX_Q13627-2 1 23 6 84503.2191 NX_Q13627-3 1 17 6 60291.3345 NX_Q13627-4 2 17 6 61730.0263 NX_Q13627-5 2 19 6 66057.0492 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-1053596,EBI-491274 RB1     .negative regulation of G1/S transition of mitotic cell cycle .hepatocyte apoptotic process .regulation of centromere complex assembly   + 39 more... .phosphoprotein binding .androgen receptor binding .identical protein binding   + 7 more... .Rb-E2F complex .PML body .SWI/SNF complex   + 4 more... 2 EBI-1053596,EBI-971402 RBL1     .regulation of cell cycle .positive regulation of transcription from RNA polymerase II promoter .regulation of lipid kinase activity   + 8 more... .transcription factor binding .transcription factor complex .nucleoplasm .nucleus 3 EBI-1053621,EBI-359815 YWHAB     .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway .intrinsic apoptotic signaling pathway .membrane organization   + 24 more... .phosphoprotein binding .phosphoserine binding .histone deacetylase binding   + 3 more... .extracellular exosome .perinuclear region of cytoplasm .melanosome   + 7 more... 4 EBI-1053596,EBI-359808 DCAF7     .protein ubiquitination .multicellular organismal development .N/A .Cul4-RING E3 ubiquitin ligase complex .protein complex .nuclear matrix   + 2 more... 5 EBI-1053596,EBI-2349743 TROAP     .cell adhesion .N/A .cytoplasm 6 EBI-1053596,EBI-741037 LZTS2     .negative regulation of protein localization to nucleus .negative regulation of canonical Wnt signaling pathway .spindle midzone assembly   + 7 more... .N/A .midbody .microtubule .centrosome .cytoplasm EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* bladder 66 blood 89 bone 27 bone marrow 41 brain 51 connective tissue 26 ear 496 embryonic tissue 56 eye 38 heart 67 intestine 25 kidney 66 liver 9 lung 53 lymph 45 lymph node 44 mammary gland 46 mouth 317 muscle 37 nerve 64 ovary 19 pituitary gland 121 placenta 60 prostate 31 skin 33 spleen 56 stomach 20 testis 39 thymus 87 thyroid 85 trachea 19 uterus 43 vascular 38 Health State Tissues TPM* normal 49 breast (mammary gland) tumor 64 chondrosarcoma 36 colorectal tumor 26 gastrointestinal tumor 33 germ cell tumor 49 glioma 55 head and neck tumor 179 kidney tumor 58 leukemia 84 liver tumor 10 lung tumor 29 lymphoma 27 non-neoplasia 62 ovarian tumor 26 primitive neuroectodermal tumor of the CNS 55 prostate cancer 28 skin tumor 39 soft tissue/muscle tissue tumor 23 uterine tumor 44 Developmental Stage Tissues TPM* adult 51 embryoid body 71 fetus 71 infant 127 juvenile 71 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 20.1 adrenal gland 26 appendix 30.7 bone marrow 75.1 cerebral cortex 28.8 colon 23.3 duodenum 21.2 esophagus 26.5 gallbladder 30.1 heart muscle 34.1 kidney 22.5 liver 15 lung 27.8 lymph node 39.4 ovary 40.2 pancreas 14.2 placenta 32.6 prostate 22.8 salivary gland 19.8 skin 22.6 small intestine 23.9 spleen 42.3 stomach 28.8 testis 45.3 thyroid gland 39.8 urinary bladder 36.5 Tissues Tissues Expression level adrenal gland Medium appendix High bone marrow Low breast High bronchus Medium cerebellum Medium cerebral cortex Low cervix, uterine High colon Medium duodenum Medium endometrium 1 Medium endometrium 2 Medium epididymis Medium esophagus Medium fallopian tube High gallbladder High heart muscle Low kidney Medium lung Medium lymph node Medium nasopharynx Medium oral mucosa Medium pancreas Medium parathyroid gland Medium placenta High prostate Medium rectum Medium salivary gland High seminal vesicle Medium skeletal muscle Medium skin 1 Low skin 2 Medium small intestine High smooth muscle Medium soft tissue 1 Low soft tissue 2 Low spleen Medium stomach 1 Medium stomach 2 Medium testis Medium thyroid gland Medium tonsil Medium urinary bladder Medium vagina Medium Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Expression level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (*600855, gene) Dual-specificity tyrosine phosphorylation-regulated kinase 1a; DYRK1A OMIM 2 (#614104, phenotype) Mental retardation, autosomal dominant 7; MRD7 OMIM

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