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> Protein (NX_Q13627)
Protein (NX_Q13627)
Protein
Gene SymbolDYRK1A to neXtProt (NX_Q13627)
DescriptionDual specificity tyrosine-phosphorylation-regulated kinase 1A
Chromosome21
Location21q22.13 (38738092 ~ 38889753) to Ensembl
Sequene Features : Isoforms 5, Variants 100, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein deacetylation
.protein autophosphorylation
.negative regulation of DNA damage response, signal transduction by p53 class mediator
  + 8 more...
.tau protein binding
.protein self-association
.ATP binding
  + 5 more...
.ribonucleoprotein complex
.nuclear speck
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 100 13
2014-09-19protein level
5 82 13
2014-05-27protein level
5 80 14
2014-02-25protein level
5 78 7
2013-12-09protein level
5 60 7
2013-11-01protein level
5 58 7
2013-09-12protein level
5 58 7
2013-08-17protein level
5 58 7
2013-07-15protein level
5 41 6
2013-06-11protein level
5 41 6
2013-02-12protein level
5 15 29
2012-12-20protein level
5 15 29
2012-10-30protein level
5 21 29
2012-10-07protein level
5 21 7
2012-08-24protein level
5 20 7
2012-07-28protein level
5 20 7
2012-06-08protein level
5 29 7
2012-05-07protein level
5 19 7
2012-04-10protein level
5 19 7
2012-01-13protein level
5 16 7
2011-12-20protein level
5 16 7
2011-11-11protein level
5 16 8
2011-08-23protein level
5 16 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13627-1
0 24 6 85529.7405
NX_Q13627-2
1 23 6 84503.2191
NX_Q13627-3
1 17 6 60291.3345
NX_Q13627-4
2 17 6 61730.0263
NX_Q13627-5
2 19 6 66057.0492
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1053596,EBI-491274 RB1  
  .negative regulation of G1/S transition of mitotic cell cycle
.hepatocyte apoptotic process
.regulation of centromere complex assembly
  + 39 more...
.phosphoprotein binding
.androgen receptor binding
.identical protein binding
  + 7 more...
.Rb-E2F complex
.PML body
.SWI/SNF complex
  + 4 more...
2 EBI-1053596,EBI-971402 RBL1  
  .regulation of cell cycle
.positive regulation of transcription from RNA polymerase II promoter
.regulation of lipid kinase activity
  + 8 more...
.transcription factor binding .transcription factor complex
.nucleoplasm
.nucleus
3 EBI-1053621,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
4 EBI-1053596,EBI-359808 DCAF7  
  .protein ubiquitination
.multicellular organismal development
.N/A .Cul4-RING E3 ubiquitin ligase complex
.protein complex
.nuclear matrix
  + 2 more...
5 EBI-1053596,EBI-2349743 TROAP  
  .cell adhesion .N/A .cytoplasm
6 EBI-1053596,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
blood89
bone27
bone marrow41
brain51
connective tissue26
ear496
embryonic tissue56
eye38
heart67
intestine25
kidney66
liver9
lung53
lymph45
lymph node44
mammary gland46
mouth317
muscle37
nerve64
ovary19
pituitary gland121
placenta60
prostate31
skin33
spleen56
stomach20
testis39
thymus87
thyroid85
trachea19
uterus43
vascular38
Health State
TissuesTPM*
normal49
breast (mammary gland) tumor64
chondrosarcoma36
colorectal tumor26
gastrointestinal tumor33
germ cell tumor49
glioma55
head and neck tumor179
kidney tumor58
leukemia84
liver tumor10
lung tumor29
lymphoma27
non-neoplasia62
ovarian tumor26
primitive neuroectodermal tumor of the CNS55
prostate cancer28
skin tumor39
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult51
embryoid body71
fetus71
infant127
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.1
adrenal gland26
appendix30.7
bone marrow75.1
cerebral cortex28.8
colon23.3
duodenum21.2
esophagus26.5
gallbladder30.1
heart muscle34.1
kidney22.5
liver15
lung27.8
lymph node39.4
ovary40.2
pancreas14.2
placenta32.6
prostate22.8
salivary gland19.8
skin22.6
small intestine23.9
spleen42.3
stomach28.8
testis45.3
thyroid gland39.8
urinary bladder36.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastHigh
bronchusMedium
cerebellumMedium
cerebral cortexLow
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
kidneyMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Low
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600855, gene) Dual-specificity tyrosine phosphorylation-regulated kinase 1a; DYRK1AOMIM
2(#614104, phenotype) Mental retardation, autosomal dominant 7; MRD7OMIM


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