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Protein |
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Gene Symbol | DYRK1A to neXtProt (NX_Q13627) |
Description | Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
Chromosome | 21 |
Location | 21q22.13 (38738092 ~ 38889753) to Ensembl |
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Sequene Features : Isoforms 5, Variants 100, PTMs 13 to neXtProt Sequence Features
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Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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.positive regulation of protein deacetylation .protein autophosphorylation .negative regulation of DNA damage response, signal transduction by p53 class mediator + 8 more... |
.tau protein binding .protein self-association .ATP binding + 5 more... |
.ribonucleoprotein complex .nuclear speck .nucleoplasm .nucleus |
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Proteomic Evidences |
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Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
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2015-01-01 | | protein level | | | | | | | 5 |
| 100 |
| 13 |
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2014-09-19 | | protein level | | | | | | | 5 |
| 82 |
| 13 |
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2014-05-27 | | protein level | | | | | | | 5 |
| 80 |
| 14 |
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2014-02-25 | | protein level | | | | | | | 5 |
| 78 |
| 7 |
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2013-12-09 | | protein level | | | | | | | 5 |
| 60 |
| 7 |
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2013-11-01 | | protein level | | | | | | | 5 |
| 58 |
| 7 |
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2013-09-12 | | protein level | | | | | | | 5 |
| 58 |
| 7 |
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2013-08-17 | | protein level | | | | | | | 5 |
| 58 |
| 7 |
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2013-07-15 | | protein level | | | | | | | 5 |
| 41 |
| 6 |
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2013-06-11 | | protein level | | | | | | | 5 |
| 41 |
| 6 |
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2013-02-12 | | protein level | | | | | | | 5 |
| 15 |
| 29 |
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2012-12-20 | | protein level | | | | | | | 5 |
| 15 |
| 29 |
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2012-10-30 | | protein level | | | | | | | 5 |
| 21 |
| 29 |
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2012-10-07 | | protein level | | | | | | | 5 |
| 21 |
| 7 |
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2012-08-24 | | protein level | | | | | | | 5 |
| 20 |
| 7 |
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2012-07-28 | | protein level | | | | | | | 5 |
| 20 |
| 7 |
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2012-06-08 | | protein level | | | | | | | 5 |
| 29 |
| 7 |
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2012-05-07 | | protein level | | | | | | | 5 |
| 19 |
| 7 |
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2012-04-10 | | protein level | | | | | | | 5 |
| 19 |
| 7 |
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2012-01-13 | | protein level | | | | | | | 5 |
| 16 |
| 7 |
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2011-12-20 | | protein level | | | | | | | 5 |
| 16 |
| 7 |
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2011-11-11 | | protein level | | | | | | | 5 |
| 16 |
| 8 |
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2011-08-23 | | protein level | | | | | | | 5 |
| 16 |
| 8 |
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Protein Isoforms |
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| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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Interacting Partners |
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No. |
Exp. ref. |
Symbol |
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PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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1 |
EBI-1053596,EBI-491274 |
RB1 |
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.negative regulation of G1/S transition of mitotic cell cycle .hepatocyte apoptotic process .regulation of centromere complex assembly + 39 more... |
.phosphoprotein binding .androgen receptor binding .identical protein binding + 7 more... |
.Rb-E2F complex .PML body .SWI/SNF complex + 4 more... |
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2 |
EBI-1053596,EBI-971402 |
RBL1 |
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.regulation of cell cycle .positive regulation of transcription from RNA polymerase II promoter .regulation of lipid kinase activity + 8 more... |
.transcription factor binding |
.transcription factor complex .nucleoplasm .nucleus |
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3 |
EBI-1053621,EBI-359815 |
YWHAB |
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.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway .intrinsic apoptotic signaling pathway .membrane organization + 24 more... |
.phosphoprotein binding .phosphoserine binding .histone deacetylase binding + 3 more... |
.extracellular exosome .perinuclear region of cytoplasm .melanosome + 7 more... |
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4 |
EBI-1053596,EBI-359808 |
DCAF7 |
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.protein ubiquitination .multicellular organismal development |
.N/A |
.Cul4-RING E3 ubiquitin ligase complex .protein complex .nuclear matrix + 2 more... |
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5 |
EBI-1053596,EBI-2349743 |
TROAP |
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.cell adhesion |
.N/A |
.cytoplasm |
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6 |
EBI-1053596,EBI-741037 |
LZTS2 |
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.negative regulation of protein localization to nucleus .negative regulation of canonical Wnt signaling pathway .spindle midzone assembly + 7 more... |
.N/A |
.midbody .microtubule .centrosome .cytoplasm |
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EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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Body Sites | |
Tissues | TPM* | |
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bladder | 66 | |
blood | 89 | |
bone | 27 | |
bone marrow | 41 | |
brain | 51 | |
connective tissue | 26 | |
ear | 496 | |
embryonic tissue | 56 | |
eye | 38 | |
heart | 67 | |
intestine | 25 | |
kidney | 66 | |
liver | 9 | |
lung | 53 | |
lymph | 45 | |
lymph node | 44 | |
mammary gland | 46 | |
mouth | 317 | |
muscle | 37 | |
nerve | 64 | |
ovary | 19 | |
pituitary gland | 121 | |
placenta | 60 | |
prostate | 31 | |
skin | 33 | |
spleen | 56 | |
stomach | 20 | |
testis | 39 | |
thymus | 87 | |
thyroid | 85 | |
trachea | 19 | |
uterus | 43 | |
vascular | 38 | |
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Health State | |
Tissues | TPM* | |
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normal | 49 | |
breast (mammary gland) tumor | 64 | |
chondrosarcoma | 36 | |
colorectal tumor | 26 | |
gastrointestinal tumor | 33 | |
germ cell tumor | 49 | |
glioma | 55 | |
head and neck tumor | 179 | |
kidney tumor | 58 | |
leukemia | 84 | |
liver tumor | 10 | |
lung tumor | 29 | |
lymphoma | 27 | |
non-neoplasia | 62 | |
ovarian tumor | 26 | |
primitive neuroectodermal tumor of the CNS | 55 | |
prostate cancer | 28 | |
skin tumor | 39 | |
soft tissue/muscle tissue tumor | 23 | |
uterine tumor | 44 | |
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Developmental Stage | |
Tissues | TPM* | |
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adult | 51 | |
embryoid body | 71 | |
fetus | 71 | |
infant | 127 | |
juvenile | 71 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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Expression level of Protein (ref. Human Protein Atlas) |
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RNA-Seq. | |
Tissues | FPKM | |
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adipose tissue | 20.1 | |
adrenal gland | 26 | |
appendix | 30.7 | |
bone marrow | 75.1 | |
cerebral cortex | 28.8 | |
colon | 23.3 | |
duodenum | 21.2 | |
esophagus | 26.5 | |
gallbladder | 30.1 | |
heart muscle | 34.1 | |
kidney | 22.5 | |
liver | 15 | |
lung | 27.8 | |
lymph node | 39.4 | |
ovary | 40.2 | |
pancreas | 14.2 | |
placenta | 32.6 | |
prostate | 22.8 | |
salivary gland | 19.8 | |
skin | 22.6 | |
small intestine | 23.9 | |
spleen | 42.3 | |
stomach | 28.8 | |
testis | 45.3 | |
thyroid gland | 39.8 | |
urinary bladder | 36.5 | |
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Tissues | |
Tissues | Expression level |
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adrenal gland | Medium | |
appendix | High | |
bone marrow | Low | |
breast | High | |
bronchus | Medium | |
cerebellum | Medium | |
cerebral cortex | Low | |
cervix, uterine | High | |
colon | Medium | |
duodenum | Medium | |
endometrium 1 | Medium | |
endometrium 2 | Medium | |
epididymis | Medium | |
esophagus | Medium | |
fallopian tube | High | |
gallbladder | High | |
heart muscle | Low | |
kidney | Medium | |
lung | Medium | |
lymph node | Medium | |
nasopharynx | Medium | |
oral mucosa | Medium | |
pancreas | Medium | |
parathyroid gland | Medium | |
placenta | High | |
prostate | Medium | |
rectum | Medium | |
salivary gland | High | |
seminal vesicle | Medium | |
skeletal muscle | Medium | |
skin 1 | Low | |
skin 2 | Medium | |
small intestine | High | |
smooth muscle | Medium | |
soft tissue 1 | Low | |
soft tissue 2 | Low | |
spleen | Medium | |
stomach 1 | Medium | |
stomach 2 | Medium | |
testis | Medium | |
thyroid gland | Medium | |
tonsil | Medium | |
urinary bladder | Medium | |
vagina | Medium | |
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Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
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RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) |
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Moderately expressed RNAs (50> FPKM >10) |
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Lower expressed RNAs (10> FPKM >1) |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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Expression level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Staining level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Not Detected |
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Disease |
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No. | Disease Description | Ref. |
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1 | (*600855, gene) Dual-specificity tyrosine phosphorylation-regulated kinase 1a; DYRK1A | OMIM |
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2 | (#614104, phenotype) Mental retardation, autosomal dominant 7; MRD7 | OMIM |
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