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> Protein (NX_Q13643)
Protein (NX_Q13643)
Gene SymbolFHL3 to neXtProt (NX_Q13643)
DescriptionFour and a half LIM domains protein 3
Location1p34.3 (38462442 ~ 38471278) to Ensembl
Sequene Features : Isoforms 1, Variants 38, PTMsto neXtProt Sequence Features
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.actin cytoskeleton organization
.muscle organ development
.zinc ion binding .Z disc
.focal adhesion
.stress fiber
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 38 5
2014-09-19protein level
1 29 5
2014-05-27protein level
1 29 5
2014-02-25protein level
1 29 3
2013-12-09protein level
1 14 3
2013-11-01protein level
1 14 2
2013-09-12protein level
1 14 1
2013-08-17protein level
1 14 1
2013-07-15protein level
1 12 0
2013-06-11protein level
1 12 0
2013-02-12protein level
1 8 0
2012-12-20protein level
1 9 0
2012-10-30protein level
1 13 0
2012-10-07protein level
1 13 0
2012-08-24protein level
1 12 0
2012-07-28protein level
1 11 0
2012-06-08protein level
1 22 0
2012-05-07protein level
1 22 0
2012-04-10protein level
1 22 0
2012-01-13protein level
1 15 0
2011-12-20protein level
1 15 0
2011-11-11protein level
1 15 0
2011-08-23protein level
1 15 0
Protein Isoforms
Isoform Ac UGSMw (Da)
13 0 0 31170.5198
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741101,EBI-7779316 E2F8  
  .hepatocyte differentiation
.chorionic trophoblast cell differentiation
.trophoblast giant cell differentiation
  + 8 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
  + 2 more...
.transcription factor complex
2 EBI-741101,EBI-9088235 MYBPHL  
  .N/A .N/A .N/A
3 EBI-741101,EBI-10173222 DCDC2B  
  .intracellular signal transduction .N/A .N/A
4 EBI-741101,EBI-10182841 P4HA2  
  .peptidyl-proline hydroxylation to 4-hydroxy-L-proline .L-ascorbic acid binding
.oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
.electron carrier activity
  + 2 more...
.intracellular membrane-bounded organelle
.procollagen-proline 4-dioxygenase complex
.endoplasmic reticulum lumen
  + 3 more...
5 EBI-741101,EBI-80739 RAD21  
  .protein localization to chromatin
.cell division
.cellular protein metabolic process
  + 10 more...
.N/A .nuclear meiotic cohesin complex
.cohesin complex
  + 5 more...
6 EBI-741101,EBI-10188645 GCM2  
  .cellular response to organic substance
.parathyroid gland development
.negative regulation of apoptotic process
  + 6 more...
.metal ion binding
.sequence-specific DNA binding
.DNA binding
7 EBI-741101,EBI-2115136 AMBP  
  .negative regulation of immune response
.negative regulation of JNK cascade
.heme catabolic process
  + 7 more...
.calcium oxalate binding
.protein homodimerization activity
.small molecule binding
  + 4 more...
.blood microparticle
.extracellular exosome
.intracellular membrane-bounded organelle
  + 4 more...
8 EBI-741101,EBI-2872294 CSF1  
  .positive regulation of glial cell migration
.positive regulation of macrophage colony-stimulating factor signaling pathway
.mammary duct terminal end bud growth
  + 33 more...
.protein homodimerization activity
.growth factor activity
.macrophage colony-stimulating factor receptor binding
.cytokine activity
.CSF1-CSF1R complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 5 more...
9 EBI-741101,EBI-3893419 FOSL2  
  .response to cAMP
.response to corticosterone
.positive regulation of fibroblast proliferation
  + 9 more...
.sequence-specific DNA binding transcription factor activity
.double-stranded DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
10 EBI-741101,EBI-2806671 GATA2  
  .regulation of forebrain neuron differentiation
.negative regulation of neural precursor cell proliferation
.GABAergic neuron differentiation
  + 29 more...
.C2H2 zinc finger domain binding
.zinc ion binding
.transcription factor binding
  + 5 more...
.protein complex
11 EBI-741101,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
12 EBI-741101,EBI-78260 PTPN6  
  .regulation of G1/S transition of mitotic cell cycle
.platelet aggregation
.regulation of ERK1 and ERK2 cascade
  + 33 more...
.protein kinase binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.alpha-beta T cell receptor complex
  + 5 more...
13 EBI-741101,EBI-1383454 TYK2  
  .regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
.innate immune response
  + 8 more...
.ATP binding
.growth hormone receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
  + 3 more...
14 EBI-741101,EBI-742557 RFX3  
  .positive regulation of type B pancreatic cell development
.type B pancreatic cell maturation
.epithelial cilium movement involved in determination of left/right asymmetry
  + 12 more...
.transcription regulatory region DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.transcription factor complex
.nuclear chromatin
15 EBI-741101,EBI-8472267 KLF3  
  .cellular response to peptide
.multicellular organismal development
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
16 EBI-741101,EBI-10210845 KRTAP12-1  
  .N/A .N/A .keratin filament
17 EBI-741101,EBI-10176379 KRTAP12-2  
  .N/A .N/A .keratin filament
18 EBI-741101,EBI-624585 SNRPG  
  .ncRNA metabolic process
.mRNA 3'-end processing
.gene expression
  + 7 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.SMN-Sm protein complex
  + 9 more...
19 EBI-741101,EBI-2806068 HYAL2  
  .positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of interleukin-6 secretion
.positive regulation of interleukin-8 secretion
  + 35 more...
.transforming growth factor beta binding
.hyaluronoglucuronidase activity
.receptor tyrosine kinase binding
  + 5 more...
.RNA polymerase II transcription factor complex
.perinuclear region of cytoplasm
.anchored component of plasma membrane
  + 14 more...
20 EBI-741101,EBI-745226 AIMP2  
  .Type II pneumocyte differentiation
.positive regulation of protein ubiquitination
.gene expression
  + 3 more...
.N/A .membrane
21 EBI-741101,EBI-77818 ADAM15  
  .negative regulation of receptor binding
.protein kinase C signaling
.cardiac epithelial to mesenchymal transition
  + 11 more...
.SH3 domain binding
.zinc ion binding
.metallopeptidase activity
  + 2 more...
.extracellular exosome
.cell projection
.integral component of membrane
  + 4 more...
22 EBI-741101,EBI-2798044 QRICH1  
  .N/A .N/A .nucleoplasm
23 EBI-741101,EBI-10243636 C9orf116  
  .N/A .N/A .N/A
24 EBI-741101,EBI-10244652 EPHA10  
  .ephrin receptor signaling pathway
.axon guidance
.ATP binding
.transmembrane-ephrin receptor activity
.ephrin receptor activity
.extracellular exosome
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
25 EBI-741101,EBI-10251535 EFCAB12  
  .N/A .calcium ion binding .N/A
26 EBI-741101,EBI-10254473 KIRREL2  
  .single organismal cell-cell adhesion
.cell adhesion
.negative regulation of protein phosphorylation
.N/A .slit diaphragm
.integral component of membrane
.plasma membrane
27 EBI-741101,EBI-7844656 TTLL10  
  .cellular protein modification process .N/A .N/A
28 EBI-741101,EBI-6255981 EPM2AIP1  
  .positive regulation of glycogen (starch) synthase activity
.positive regulation of glycogen biosynthetic process
.response to insulin
.N/A .endoplasmic reticulum
29 EBI-741101,EBI-10258181 UBE2Q1  
  .prolactin secretion
.reproductive system development
.protein ubiquitination
  + 4 more...
.ligase activity
.ATP binding
30 EBI-741101,EBI-2562092 PATL1  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.cytoplasmic mRNA processing body assembly
.gene expression
  + 2 more...
.poly(A) RNA binding
.poly(G) binding
.poly(U) RNA binding
.RNA binding
.intracellular membrane-bounded organelle
.nuclear speck
.PML body
  + 2 more...
31 EBI-741101,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
32 EBI-741101,EBI-692891 HIPK1  
  .extrinsic apoptotic signaling pathway
.endothelial cell apoptotic process
.iris morphogenesis
  + 15 more...
.ATP binding
.protein serine/threonine kinase activity
.nuclear speck
.PML body
33 EBI-741101,EBI-10265585 SLC44A3  
  .transmembrane transport
.glycerophospholipid biosynthetic process
.small molecule metabolic process
  + 2 more...
.N/A .integral component of membrane
.plasma membrane
34 EBI-741101,EBI-10269374 SLAIN1  
  .N/A .N/A .N/A
35 EBI-741101,EBI-741032 CNNM3  
  .ion transport .N/A .integral component of membrane
.plasma membrane
36 EBI-741101,EBI-752049 FAM71C  
  .N/A .N/A .N/A
37 EBI-741101,EBI-742060 TYMSOS  
  .N/A .N/A .N/A
38 EBI-741101,EBI-746555 RHEBL1  
  .positive regulation of NF-kappaB transcription factor activity
.TOR signaling
.small GTPase mediated signal transduction
.metal ion binding
.GTP binding
.endomembrane system
39 EBI-741101,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
40 EBI-741101,EBI-10281975 SLC25A46  
  .transport .N/A .integral component of membrane
.mitochondrial inner membrane
41 EBI-741101,EBI-745085 PHF21A  
  .chromatin modification
.blood coagulation
.regulation of transcription, DNA-templated
  + 4 more...
.zinc ion binding
.chromatin binding
.DNA binding
.histone deacetylase complex
42 EBI-741101,EBI-7951092 KTI12  
  .N/A .ATP binding .N/A
43 EBI-741101,EBI-2514069 TMX3  
  .cell redox homeostasis
.response to endoplasmic reticulum stress
.protein folding
.protein disulfide isomerase activity .integral component of membrane
.cell surface
.endoplasmic reticulum membrane
.endoplasmic reticulum
44 EBI-741101,EBI-1049952 ZNF512B  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
45 EBI-741101,EBI-1045440 RNMTL1  
  .RNA processing
.rRNA processing
.poly(A) RNA binding
.RNA methyltransferase activity
46 EBI-741101,EBI-2809489 A1CF  
  .protein stabilization
.mRNA modification
.cytidine to uridine editing
  + 2 more...
.single-stranded RNA binding
.RNA binding
.nucleotide binding
.apolipoprotein B mRNA editing enzyme complex
.endoplasmic reticulum
47 EBI-741101,EBI-5325236 MRPL27  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial large ribosomal subunit
.mitochondrial inner membrane
48 EBI-741101,EBI-751683 SAP30BP  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.positive regulation of cell death
  + 4 more...
.N/A .intermediate filament cytoskeleton
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
adrenal gland30
connective tissue13
embryonic tissue56
lymph node122
mammary gland13
salivary gland49
Health State
adrenal tumor79
breast (mammary gland) tumor10
cervical tumor28
colorectal tumor8
esophageal tumor57
gastrointestinal tumor118
germ cell tumor7
head and neck tumor22
liver tumor20
lung tumor19
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS307
skin tumor47
soft tissue/muscle tissue tumor95
uterine tumor11
Developmental Stage
embryoid body57
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
adipose tissue13.7
adrenal gland6.8
bone marrow17.1
cerebral cortex6
heart muscle9
lymph node7.2
salivary gland8.8
small intestine5.6
thyroid gland4.6
urinary bladder18.8
TumorNumber of patients and Staining levels
breast cancer
cervical cancer
colorectal cancer
endometrial cancer
head and neck cancer
liver cancer
lung cancer
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
No.Disease DescriptionRef.
1(*602790, gene) Four-and-a-half lim domains 3; FHL3OMIM
2lieomyomatosis;renal;hereditary leiomyomatosis and renal cell cancerCGP

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