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> Protein (NX_Q13794)
Protein (NX_Q13794)
Protein
Gene SymbolPMAIP1 to neXtProt (NX_Q13794)
DescriptionPhorbol-12-myristate-13-acetate-induced protein 1
Chromosome18
Location18q21.32 (57567180 ~ 57571538) to Ensembl
Sequene Features : Isoforms 2, Variants 8, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 27 more...
.N/A .cytosol
.mitochondrial outer membrane
.mitochondrion
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 8 4
2014-09-19protein level
1 2 4
2014-05-27protein level
1 2 4
2014-02-25protein level
1 2 4
2013-12-09protein level
1 1 4
2013-11-01protein level
1 1 3
2013-09-12protein level
1 1 3
2013-08-17protein level
1 1 3
2013-07-15protein level
1 1 1
2013-06-11protein level
1 1 1
2013-02-12protein level
1 1 0
2012-12-20protein level
1 1 0
2012-10-30protein level
1 1 0
2012-10-07protein level
1 1 0
2012-08-24protein level
1 1 0
2012-07-28protein level
1 1 0
2012-06-08protein level
1 6 0
2012-05-07protein level
1 8 0
2012-04-10protein level
1 8 0
2012-01-13protein level
1 7 0
2011-12-20protein level
1 7 0
2011-11-11protein level
1 7 0
2011-08-23protein level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13794-1
1 1 0 6026.2217
NX_Q13794-2
7 1 0 14945.6425
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-707392,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
2 EBI-707392,EBI-1003422 MCL1  
  .negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of response to DNA damage stimulus
  + 10 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
.protein channel activity
.Bcl-2 family protein complex
.integral component of membrane
.membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder133
blood98
bone41
bone marrow102
brain18
cervix20
connective tissue13
embryonic tissue84
esophagus49
eye14
intestine12
kidney9
liver19
lung35
lymph22
lymph node89
mammary gland13
muscle9
ovary39
pancreas23
placenta49
prostate5
salivary gland98
skin14
spleen18
stomach20
testis22
thymus12
trachea19
uterus21
Health State
TissuesTPM*
normal24
bladder carcinoma170
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma36
colorectal tumor8
esophageal tumor57
gastrointestinal tumor16
germ cell tumor56
kidney tumor14
leukemia42
liver tumor10
lung tumor38
lymphoma69
ovarian tumor52
primitive neuroectodermal tumor of the CNS102
prostate cancer9
retinoblastoma64
skin tumor15
soft tissue/muscle tissue tumor47
uterine tumor22
Developmental Stage
TissuesTPM*
adult25
embryoid body85
blastocyst195
fetus3
infant212
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.1
appendix9.1
bone marrow51.9
cerebral cortex2.6
colon2.9
duodenum3.5
esophagus11.7
gallbladder8.6
kidney1.4
liver1.1
lung2.7
lymph node14.5
placenta14.1
prostate3.1
salivary gland1
skin8.4
small intestine4.3
spleen4.5
stomach2.8
testis3.7
thyroid gland2.5
urinary bladder12.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604959, gene) Phorbol-12-myristate-13-acetate-induced protein 1; PMAIP1OMIM


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