Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q13829)
Protein (NX_Q13829)
Protein
Gene SymbolTNFAIP1 to neXtProt (NX_Q13829)
DescriptionBTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
Chromosome17
Location17q11.2 (26662628 ~ 26674035) to Ensembl
Sequene Features : Isoforms 2, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein homooligomerization
.positive regulation of DNA replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 8 more...
.GTP-Rho binding .Cul3-RING ubiquitin ligase complex
.endosome
.cytoplasm
.nucleolus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 33 4
2014-09-19protein level
1 22 4
2014-05-27protein level
1 22 4
2014-02-25protein level
1 22 4
2013-12-09protein level
1 16 4
2013-11-01protein level
1 16 3
2013-09-12protein level
1 16 3
2013-08-17protein level
1 16 3
2013-07-15protein level
1 12 2
2013-06-11protein level
1 12 2
2013-02-12protein level
1 5 3
2012-12-20protein level
1 5 3
2012-10-30protein level
1 8 3
2012-10-07protein level
1 8 3
2012-08-24protein level
1 8 3
2012-07-28protein level
1 8 3
2012-06-08protein level
1 14 3
2012-05-07protein level
1 12 3
2012-04-10protein level
1 12 3
2012-01-13protein level
1 9 3
2011-12-20protein level
1 9 3
2011-11-11protein level
1 9 3
2011-08-23protein level
1 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13829-1
4 9 2 36181.2112
NX_Q13829-2
0 9 1 24693.3912
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2505861,EBI-2339359 HAT1  
  .histone H4 acetylation
.response to nutrient
.internal protein amino acid acetylation
  + 5 more...
.H4 histone acetyltransferase activity
.histone acetyltransferase activity
.protein complex
.intracellular membrane-bounded organelle
.nuclear matrix
  + 4 more...
2 EBI-2505861,EBI-1055079 POLR1C  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
3 EBI-2505861,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
4 EBI-2505861,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
5 EBI-2505861,EBI-602647 RHOB  
  .cellular response to ionizing radiation
.cellular response to hydrogen peroxide
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.cleavage furrow
.late endosome membrane
  + 6 more...
6 EBI-2505861,EBI-456129 CUL3  
  .intrinsic apoptotic signaling pathway
.negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
  + 22 more...
.POZ domain binding .extracellular exosome
.Cul3-RING ubiquitin ligase complex
.membrane
  + 4 more...
7 EBI-2505861,EBI-6255981 EPM2AIP1  
  .positive regulation of glycogen (starch) synthase activity
.positive regulation of glycogen biosynthetic process
.response to insulin
.N/A .endoplasmic reticulum
.nucleus
8 EBI-2505861,EBI-742916 KCTD13  
  .protein homooligomerization
.positive regulation of DNA replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 5 more...
.GTP-Rho binding .Cul3-RING ubiquitin ligase complex
.nucleoplasm
.nucleus
9 EBI-2505861,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
10 EBI-2505861,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
.nucleus
11 EBI-2505861,EBI-371876 EXOSC5  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.nuclear mRNA surveillance
  + 10 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder33
blood49
bone55
bone marrow20
brain146
cervix61
connective tissue80
embryonic tissue89
esophagus49
eye81
heart67
intestine99
kidney42
liver116
lung116
lymph90
lymph node122
mammary gland99
mouth90
muscle244
ovary49
pancreas65
parathyroid48
pharynx49
pituitary gland60
placenta240
prostate58
salivary gland345
skin147
spleen131
stomach83
testis101
thymus112
thyroid42
trachea77
umbilical cord508
uterus120
vascular77
Health State
TissuesTPM*
normal108
breast (mammary gland) tumor150
cervical tumor57
chondrosarcoma84
colorectal tumor106
esophageal tumor57
gastrointestinal tumor168
germ cell tumor155
glioma83
head and neck tumor112
kidney tumor14
leukemia21
liver tumor187
lung tumor155
lymphoma83
non-neoplasia62
ovarian tumor52
pancreatic tumor57
primitive neuroectodermal tumor of the CNS31
prostate cancer77
retinoblastoma43
skin tumor175
soft tissue/muscle tissue tumor151
uterine tumor122
Developmental Stage
TissuesTPM*
adult92
embryoid body200
blastocyst48
neonate160
fetus89
infant127
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.8
adrenal gland22
appendix15.1
bone marrow4
cerebral cortex21.1
colon15.6
duodenum12.9
esophagus27.1
gallbladder24.6
heart muscle22.5
kidney18.5
liver19.5
lung35.1
lymph node13.2
ovary12.2
pancreas16.2
placenta32
prostate14.6
salivary gland10.8
skin19.1
small intestine13.9
spleen34.1
stomach15.9
testis17.5
thyroid gland20.6
urinary bladder25.5
Tissues
TissuesExpression level
bronchusLow
colonLow
duodenumMedium
kidneyLow
nasopharynxLow
pancreasHigh
salivary glandMedium
small intestineMedium
smooth muscleLow
stomach 1Low
stomach 2Medium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*191161, gene) Tumor necrosis factor-alpha-induced protein 1; TNFAIP1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center