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> Protein (NX_Q13882)
Protein (NX_Q13882)
Protein
Gene SymbolPTK6 to neXtProt (NX_Q13882)
DescriptionProtein-tyrosine kinase 6
Chromosome20
Location20q13.33 (62159778 ~ 62168723) to Ensembl
Sequene Features : Isoforms 2, Variants 58, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to retinoic acid
.negative regulation of protein tyrosine kinase activity
.intestinal epithelial cell differentiation
  + 12 more...
.identical protein binding
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 58 7
2014-09-19protein level
2 46 7
2014-05-27protein level
2 46 7
2014-02-25protein level
2 46 7
2013-12-09protein level
2 32 7
2013-11-01protein level
2 32 7
2013-09-12protein level
2 32 7
2013-08-17protein level
2 32 7
2013-07-15protein level
2 25 7
2013-06-11protein level
2 25 7
2013-02-12protein level
2 17 11
2012-12-20protein level
2 15 11
2012-10-30protein level
2 19 11
2012-10-07protein level
2 19 8
2012-08-24protein level
2 15 8
2012-07-28protein level
2 16 8
2012-06-08protein level
2 23 8
2012-05-07protein level
2 22 8
2012-04-10protein level
2 22 8
2012-01-13protein level
2 15 8
2011-12-20protein level
2 15 8
2011-11-11protein level
1 12 4
2011-08-23protein level
1 12 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13882-1
20 5 1 51801.0361
NX_Q13882-2
3 5 0 14456.1226
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1383632,EBI-957615 WASL  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of lymphocyte migration
.positive regulation of clathrin-mediated endocytosis
  + 24 more...
.GTPase regulator activity .extracellular exosome
.endocytic vesicle membrane
.actin cap
  + 6 more...
2 EBI-1383632,EBI-719823 FCHO1  
  .clathrin-mediated endocytosis
.clathrin coat assembly
.AP-2 adaptor complex binding .coated pit
.plasma membrane
3 EBI-1383632,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
4 EBI-1383632,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
5 EBI-1383632,EBI-355453 SFPQ  
  .positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.histone H3 deacetylation
.rhythmic process
  + 9 more...
.poly(A) RNA binding
.transcription regulatory region DNA binding
.histone deacetylase binding
  + 3 more...
.paraspeckles
.nuclear matrix
.cytoplasm
  + 3 more...
6 EBI-1383632,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
7 EBI-1383632,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
8 EBI-1383632,EBI-2349927 EFHC2  
  .N/A .calcium ion binding .N/A
9 EBI-1383632,EBI-742808 KHDRBS2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder100
blood16
brain2
cervix185
connective tissue13
esophagus148
heart11
intestine81
kidney4
liver4
lung8
lymph node89
mammary gland19
mouth136
pancreas32
prostate10
skin18
stomach20
trachea38
uterus12
Health State
TissuesTPM*
normal7
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma12
colorectal tumor79
esophageal tumor173
gastrointestinal tumor75
glioma18
head and neck tumor14
leukemia10
liver tumor10
lung tumor29
non-neoplasia20
pancreatic tumor66
prostate cancer9
skin tumor7
Developmental Stage
TissuesTPM*
adult13
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix3.2
colon21.8
duodenum23.6
esophagus49.9
gallbladder3.6
liver1
lung2.7
prostate1.3
salivary gland5.1
skin39.3
small intestine18.4
stomach25
urinary bladder10.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602004, gene) Protein-tyrosine kinase 6; PTK6OMIM


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