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> Protein (NX_Q13895)
Protein (NX_Q13895)
Protein
Gene SymbolBYSL to neXtProt (NX_Q13895)
DescriptionBystin
Chromosome6
Location6p21.1 (41888926 ~ 41900784) to Ensembl
Sequene Features : Isoforms 1, Variants 48, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 48 6
2014-09-19protein level
1 41 6
2014-05-27protein level
1 41 6
2014-02-25protein level
1 41 5
2013-12-09protein level
1 23 5
2013-11-01protein level
1 21 4
2013-09-12protein level
1 21 4
2013-08-17protein level
1 21 4
2013-07-15protein level
1 18 3
2013-06-11protein level
1 18 3
2013-02-12protein level
1 12 4
2012-12-20protein level
1 12 4
2012-10-30protein level
1 14 4
2012-10-07protein level
1 14 4
2012-08-24protein level
1 12 4
2012-07-28protein level
1 12 4
2012-06-08protein level
1 14 4
2012-05-07protein level
1 14 4
2012-04-10protein level
1 14 4
2012-01-13protein level
1 12 4
2011-12-20protein level
1 12 4
2011-11-11protein level
1 12 3
2011-08-23protein level
1 12 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13895-1
23 0 0 49569.8546
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-358049,EBI-2340316 MID1  
  .interferon-gamma-mediated signaling pathway
.protein localization to microtubule
.positive regulation of stress-activated MAPK cascade
  + 4 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.microtubule associated complex
.microtubule
.cytosol
.spindle
2 EBI-358049,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-358049,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
4 EBI-358049,EBI-741602 TRIM37  
  .aggresome assembly
.protein autoubiquitination
.positive regulation of NF-kappaB transcription factor activity
  + 7 more...
.ubiquitin protein ligase activity
.protein homodimerization activity
.ubiquitin protein ligase binding
  + 5 more...
.perinuclear region of cytoplasm
.aggresome
.cytosol
  + 2 more...
5 EBI-358049,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
6 EBI-358049,EBI-945751 COIL  
  .N/A .identical protein binding
.protein C-terminus binding
.membrane
.Cajal body
.cytoplasm
  + 3 more...
7 EBI-358049,EBI-489887 EMD  
  .cellular response to growth factor stimulus
.regulation of canonical Wnt signaling pathway
.negative regulation of fibroblast proliferation
  + 8 more...
.beta-tubulin binding
.actin binding
.nuclear membrane
.integral component of membrane
.membrane
  + 5 more...
8 EBI-358049,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
9 EBI-358049,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
10 EBI-358049,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
11 EBI-358049,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
12 EBI-358049,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
13 EBI-358049,EBI-2349743 TROAP  
  .cell adhesion .N/A .cytoplasm
14 EBI-358049,EBI-950001 TRO  
  .negative regulation of cell growth
.embryo implantation
.homophilic cell adhesion via plasma membrane adhesion molecules
.N/A .integral component of plasma membrane
.plasma membrane
.cytoplasm
.nucleus
15 EBI-358049,EBI-375576 EPS8  
  .actin polymerization-dependent cell motility
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.Rac GTPase binding
.SH3/SH2 adaptor activity
.actin binding
.extracellular exosome
.ruffle membrane
.stereocilium
  + 6 more...
16 EBI-358049,EBI-745226 AIMP2  
  .Type II pneumocyte differentiation
.positive regulation of protein ubiquitination
.gene expression
  + 3 more...
.N/A .membrane
.cytosol
.nucleus
17 EBI-358049,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
18 EBI-358049,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
19 EBI-358049,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
20 EBI-358049,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
21 EBI-358049,EBI-395421 SMN2  
  .ncRNA metabolic process
.gene expression
.nervous system development
  + 2 more...
.identical protein binding
.RNA binding
.Gemini of coiled bodies
.SMN-Sm protein complex
.SMN complex
  + 7 more...
22 EBI-358049,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
23 EBI-358049,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
24 EBI-358049,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
25 EBI-358049,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
26 EBI-358049,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
27 EBI-358049,EBI-946029 C1orf94  
  .N/A .N/A .N/A
28 EBI-358049,EBI-10225049 OLIG3  
  .spinal cord motor neuron migration
.spinal cord motor neuron cell fate specification
.DNA binding
.RNA polymerase II transcription corepressor activity
.nucleus
29 EBI-358049,EBI-741520 RALYL  
  .N/A .poly(A) RNA binding
.identical protein binding
.nucleotide binding
.N/A
30 EBI-358049,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
31 EBI-358049,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
32 EBI-358049,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
33 EBI-358049,EBI-10181188 BEND7  
  .N/A .N/A .extracellular exosome
34 EBI-358049,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
35 EBI-358049,EBI-10174653 DOCK8  
  .negative regulation of T cell apoptotic process
.memory T cell proliferation
.dendritic cell migration
  + 3 more...
.guanyl-nucleotide exchange factor activity .cell leading edge
.membrane
.cytosol
36 EBI-358049,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
37 EBI-358049,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
38 EBI-358049,EBI-746012 DDX17  
  .regulation of skeletal muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of intracellular estrogen receptor signaling pathway
  + 4 more...
.poly(A) RNA binding
.estrogen receptor binding
.RNA-dependent ATPase activity
  + 5 more...
.membrane
.cytoplasm
.nucleolus
  + 2 more...
39 EBI-358049,EBI-10180409 TEKT1  
  .N/A .N/A .cilium
.microtubule
.cytoplasm
.nucleus
40 EBI-358049,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
41 EBI-358049,EBI-2558389 LTV1  
  .N/A .N/A .cytoplasm
.nucleoplasm
42 EBI-358049,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
43 EBI-358049,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
44 EBI-358049,EBI-2686809 L3MBTL3  
  .erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
45 EBI-358049,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
46 EBI-358049,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
47 EBI-358049,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
48 EBI-358049,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
49 EBI-358049,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
50 EBI-358049,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
51 EBI-358049,EBI-4400866 VPS37B  
  .positive regulation of viral budding via host ESCRT complex
.positive regulation of viral release from host cell
.intracellular transport of virus
  + 7 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.midbody
  + 5 more...
52 EBI-358049,EBI-745730 ZFP64  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
53 EBI-358049,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
54 EBI-358049,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
55 EBI-358049,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
56 EBI-358049,EBI-302355 PNMA2  
  .positive regulation of apoptotic process .N/A .nucleolus
57 EBI-358049,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites225
bladder33
blood65
bone27
brain11
cervix103
connective tissue33
embryonic tissue56
esophagus49
eye47
heart11
intestine34
kidney18
liver68
lung68
lymph428
mammary gland19
mouth15
muscle37
nerve64
ovary59
pancreas84
placenta31
prostate5
salivary gland2467
skin104
spleen18
stomach52
thyroid21
uterus25
Health State
TissuesTPM*
normal17
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma36
colorectal tumor53
esophageal tumor57
gastrointestinal tumor109
germ cell tumor113
glioma65
head and neck tumor388
leukemia63
liver tumor114
lung tumor155
lymphoma346
non-neoplasia20
ovarian tumor13
pancreatic tumor171
primitive neuroectodermal tumor of the CNS70
prostate cancer9
retinoblastoma172
skin tumor167
soft tissue/muscle tissue tumor39
uterine tumor55
Developmental Stage
TissuesTPM*
adult22
embryoid body85
blastocyst32
fetus21
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.7
adrenal gland9.8
appendix10.2
bone marrow5.9
cerebral cortex5.6
colon7.4
duodenum4.2
esophagus8.7
gallbladder6.1
heart muscle5.3
kidney4.6
liver6
lung5.2
lymph node8.1
ovary8.5
pancreas5
placenta8.8
prostate6.6
salivary gland2.9
skin7.7
small intestine4
spleen5.6
stomach5.6
testis8.6
thyroid gland5.5
urinary bladder8.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603871, gene) By the ribosomal protein s6 gene, drosophila, homolog-like; BYSLOMIM


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