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> Protein (NX_Q13905)
Protein (NX_Q13905)
Protein
Gene SymbolRAPGEF1 to neXtProt (NX_Q13905)
DescriptionRap guanine nucleotide exchange factor 1
Chromosome9
Location9q34.13 (134452157 ~ 134615461) to Ensembl
Sequene Features : Isoforms 3, Variants 111, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of neural precursor cell proliferation
.cellular response to nerve growth factor stimulus
.regulation of cell junction assembly
  + 17 more...
.Rap guanyl-nucleotide exchange factor activity .cytosol
.early endosome
.endosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 111 5
2014-09-19protein level
3 89 5
2014-05-27protein level
3 89 5
2014-02-25protein level
3 89 5
2013-12-09protein level
3 67 5
2013-11-01protein level
3 67 5
2013-09-12protein level
3 67 5
2013-08-17protein level
3 67 5
2013-07-15protein level
3 38 5
2013-06-11protein level
3 38 5
2013-02-12protein level
3 17 15
2012-12-20protein level
3 18 15
2012-10-30protein level
3 23 15
2012-10-07protein level
3 23 5
2012-08-24protein level
3 10 5
2012-07-28protein level
3 10 5
2012-06-08protein level
3 20 5
2012-05-07protein level
3 20 5
2012-04-10protein level
3 20 5
2012-01-13protein level
3 18 5
2011-12-20protein level
3 18 5
2011-11-11protein level
3 17 4
2011-08-23protein level
2 17 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13905-1
0 48 0 120471.9327
NX_Q13905-2
1 45 0 116067.728
NX_Q13905-3
0 48 0 122658.1849
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-976876,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
2 EBI-976876,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
3 EBI-976876,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
4 EBI-976876,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
5 EBI-976876,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
6 EBI-976876,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
7 EBI-976876,EBI-910 CRKL  
  .parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood106
bone97
brain53
cervix61
connective tissue60
embryonic tissue42
eye38
heart44
intestine47
kidney42
larynx42
liver38
lung59
lymph270
lymph node568
mammary gland85
mouth75
muscle56
ovary19
pancreas28
pharynx49
placenta123
prostate47
salivary gland49
skin23
spleen187
stomach31
testis36
thymus75
thyroid64
trachea115
uterus30
vascular19
Health State
TissuesTPM*
normal67
breast (mammary gland) tumor96
cervical tumor86
chondrosarcoma108
colorectal tumor35
gastrointestinal tumor33
germ cell tumor87
glioma130
head and neck tumor37
kidney tumor101
leukemia105
liver tumor41
lung tumor68
lymphoma221
non-neoplasia51
ovarian tumor39
pancreatic tumor57
primitive neuroectodermal tumor of the CNS7
prostate cancer48
skin tumor15
soft tissue/muscle tissue tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult64
embryoid body57
fetus75
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.5
adrenal gland21.8
appendix43.6
bone marrow25.9
cerebral cortex36.5
colon23.1
duodenum18.1
esophagus21.7
gallbladder23.1
heart muscle38.4
kidney21.9
liver7.2
lung33.7
lymph node46.2
ovary15.5
pancreas20.3
placenta49.6
prostate18
salivary gland12.9
skin17.4
small intestine23.6
spleen37.7
stomach26.3
testis17.9
thyroid gland24.3
urinary bladder25.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600303, gene) Rap guanine nucleotide exchange factor 1; RAPGEF1OMIM


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