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> Protein (NX_Q13976)
Protein (NX_Q13976)
Protein
Gene SymbolPRKG1 to neXtProt (NX_Q13976)
DescriptioncGMP-dependent protein kinase 1
Chromosome10
Location10q11.23 (52750945 ~ 54058110) to Ensembl
Sequene Features : Isoforms 3, Variants 137, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of mitophagy in response to mitochondrial depolarization
.negative regulation of platelet aggregation
.relaxation of vascular smooth muscle
  + 9 more...
.cGMP binding
.ATP binding
.calcium channel regulator activity
.cGMP-dependent protein kinase activity
.plasma membrane
.cytosol
.Golgi apparatus
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 137 3
2014-09-19protein level
3 95 3
2014-05-27protein level
2 95 3
2014-02-25protein level
2 96 3
2013-12-09protein level
2 82 3
2013-11-01protein level
2 78 3
2013-09-12protein level
2 78 3
2013-08-17protein level
2 78 3
2013-07-15protein level
2 51 3
2013-06-11protein level
2 51 3
2013-02-12protein level
2 24 5
2012-12-20protein level
2 25 5
2012-10-30protein level
2 26 5
2012-10-07protein level
2 26 4
2012-08-24protein level
2 23 4
2012-07-28protein level
2 23 4
2012-06-08protein level
2 28 4
2012-05-07protein level
2 13 4
2012-04-10protein level
2 13 4
2012-01-13protein level
2 13 4
2011-12-20protein level
2 13 4
2011-11-11protein level
2 13 4
2011-08-23protein level
2 13 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13976-1
4 27 1 76315.7513
NX_Q13976-2
5 27 1 77754.4182
NX_Q13976-3
1 15 1 44156.3203
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3952014,EBI-745608 ZNF646  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
2 EBI-3952014,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
3 EBI-3952014,EBI-527196 BMPR2  
  .negative regulation of DNA biosynthetic process
.negative regulation of chondrocyte proliferation
.endothelial cell apoptotic process
  + 35 more...
.metal ion binding
.BMP binding
.activin receptor activity, type II
  + 2 more...
.spanning component of plasma membrane
.neuronal cell body
.dendrite
  + 8 more...
4 EBI-3952014,EBI-744506 FAM124A  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain10
connective tissue20
embryonic tissue9
eye19
heart134
intestine8
kidney14
lung8
mammary gland13
muscle37
parathyroid97
placenta14
prostate10
skin9
stomach10
testis11
thymus25
uterus12
vascular38
Health State
TissuesTPM*
normal23
chondrosarcoma12
gastrointestinal tumor16
non-neoplasia10
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult11
embryoid body14
fetus57
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6
adrenal gland8.6
appendix2.7
cerebral cortex3.2
colon5.6
duodenum2.4
esophagus8.4
gallbladder13.1
heart muscle13.8
kidney3.4
liver1.5
lung8
lymph node1.2
ovary4.8
placenta8
prostate5.7
salivary gland2.8
small intestine3.2
spleen2.1
stomach2.6
testis4.1
thyroid gland11.3
urinary bladder9.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176894, gene) Protein kinase, cgmp-dependent, regulatory, type i; PRKG1OMIM


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