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> Protein (NX_Q14011)
Protein (NX_Q14011)
Protein
Gene SymbolCIRBP to neXtProt (NX_Q14011)
DescriptionCold-inducible RNA-binding protein
Chromosome19
Location19p13.3 (1259384 ~ 1274879) to Ensembl
Sequene Features : Isoforms 3, Variants 24, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mRNA stabilization
.positive regulation of translation
.stress granule assembly
  + 3 more...
.small ribosomal subunit rRNA binding
.poly(A) RNA binding
.translation repressor activity
  + 2 more...
.cytoplasmic stress granule
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 24 5
2014-09-19protein level
1 12 5
2014-05-27protein level
1 12 5
2014-02-25protein level
1 12 1
2013-12-09protein level
1 12 1
2013-11-01protein level
1 11 1
2013-09-12protein level
1 11 1
2013-08-17protein level
1 11 1
2013-07-15protein level
1 6 1
2013-06-11protein level
1 6 1
2013-02-12protein level
1 2 0
2012-12-20protein level
1 2 0
2012-10-30protein level
1 2 0
2012-10-07protein level
1 2 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 2 0
2012-05-07protein level
1 1 0
2012-04-10protein level
1 1 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14011-1
1 6 0 18636.6757
NX_Q14011-2
1 14 0 28341.5069
NX_Q14011-3
0 10 0 26113.5418
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-538850,EBI-607085 SNRPA  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.snRNA binding
.RNA binding
.nucleotide binding
.cytoplasm
.nucleolus
.U1 snRNP
  + 2 more...
2 EBI-538850,EBI-8638511 RBMY1A1  
  .RNA splicing
.mRNA processing
.regulation of alternative mRNA splicing, via spliceosome
.mRNA binding
.nucleotide binding
.nucleus
3 EBI-538850,EBI-743526 RBMX  
  .cellular response to interleukin-1
.protein homooligomerization
.positive regulation of mRNA splicing, via spliceosome
  + 10 more...
.poly(A) RNA binding
.mRNA binding
.single-stranded RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.supraspliceosomal complex
  + 6 more...
4 EBI-538850,EBI-304185 HNRNPK  
  .regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
.positive regulation of receptor-mediated endocytosis
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
  + 2 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cell projection
  + 7 more...
5 EBI-538850,EBI-8642021 RBMY1F  
  .RNA splicing
.spermatogenesis
.mRNA processing
.RNA binding
.nucleotide binding
.nucleus
6 EBI-538850,EBI-742808 KHDRBS2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
7 EBI-538850,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
bladder368
blood155
bone13
bone marrow205
brain21
cervix164
connective tissue288
ear248
embryonic tissue32
esophagus396
eye52
heart44
intestine202
kidney23
larynx42
liver48
lung35
lymph203
lymph node11
mammary gland19
mouth30
muscle37
nerve643
ovary187
pancreas351
parathyroid48
pharynx98
pituitary gland181
placenta7
prostate126
salivary gland246
skin4
spleen18
stomach10
testis11
thymus1405
thyroid429
tonsil411
trachea347
umbilical cord72
uterus12
vascular135
Health State
TissuesTPM*
normal21
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor115
chondrosarcoma241
colorectal tumor159
esophageal tumor463
gastrointestinal tumor8
germ cell tumor11
glioma9
head and neck tumor14
kidney tumor29
leukemia306
liver tumor62
lung tumor408
lymphoma166
non-neoplasia10
ovarian tumor105
pancreatic tumor228
primitive neuroectodermal tumor of the CNS15
prostate cancer221
retinoblastoma279
skin tumor159
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult29
embryoid body400
blastocyst48
neonate64
fetus30
infant212
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue239.1
adrenal gland253.3
appendix200.4
bone marrow219.8
cerebral cortex252.3
colon156.4
duodenum166
esophagus144.7
gallbladder203.5
heart muscle245.5
kidney234.2
liver107
lung264.7
lymph node281.9
ovary548.2
pancreas207.4
placenta179.3
prostate330.6
salivary gland275.8
skin256.5
small intestine178.7
spleen313.5
stomach220.2
testis174.5
thyroid gland285
urinary bladder177.4
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*602649, gene) Cold-inducible rna-binding protein; CIRBPOMIM


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