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> Protein (NX_Q14106)
Protein (NX_Q14106)
Protein
Gene SymbolTOB2 to neXtProt (NX_Q14106)
DescriptionProtein Tob2
Chromosome22
Location22q13.2 (41829496 ~ 41843027) to Ensembl
Sequene Features : Isoforms 2, Variants 49, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of ossification
.negative regulation of osteoclast differentiation
.regulation of gene expression
  + 2 more...
.N/A .cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 49 2
2014-09-19protein level
2 39 2
2014-05-27protein level
1 39 2
2014-02-25protein level
1 37 2
2013-12-09protein level
1 28 2
2013-11-01protein level
1 27 2
2013-09-12protein level
1 27 2
2013-08-17protein level
1 27 2
2013-07-15protein level
1 18 2
2013-06-11protein level
1 18 2
2013-02-12protein level
1 9 1
2012-12-20protein level
1 9 1
2012-10-30protein level
1 11 1
2012-10-07protein level
1 11 1
2012-08-24protein level
1 11 1
2012-07-28protein level
1 11 1
2012-06-08protein level
1 14 1
2012-05-07protein level
1 14 1
2012-04-10protein level
1 14 1
2012-01-13protein level
1 7 1
2011-12-20protein level
1 7 1
2011-11-11protein level
1 7 1
2011-08-23protein level
1 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14106-1
3 11 0 36609.1668
NX_Q14106-2
1 11 0 27174.7271
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2562000,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-2562000,EBI-81531 PABPC1  
  .negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 12 more...
.poly(A) RNA binding
.translation activator activity
.poly(U) RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
  + 7 more...
3 EBI-2562000,EBI-742887 CEP76  
  .regulation of centriole replication
.organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .protein complex
.cytosol
.centriole
.centrosome
4 EBI-2562000,EBI-742299 CNOT8  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of mRNA catabolic process
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
  + 9 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.RNA binding
  + 2 more...
.CCR4-NOT complex
.cytosol
.nucleus
.intracellular
5 EBI-2562000,EBI-2105113 CNOT7  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of mRNA catabolic process
  + 17 more...
.metal ion binding
.signal transducer activity
.poly(A)-specific ribonuclease activity
  + 4 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites50
bladder66
blood24
bone125
brain46
cervix268
connective tissue60
ear124
embryonic tissue75
eye114
heart67
intestine47
kidney66
liver24
lung62
lymph22
lymph node144
mammary gland33
mouth15
muscle47
nerve128
ovary39
pancreas23
parathyroid48
placenta38
prostate116
skin80
spleen18
stomach41
testis29
thymus50
thyroid85
uterus73
vascular38
Health State
TissuesTPM*
normal54
adrenal tumor79
breast (mammary gland) tumor42
cervical tumor115
chondrosarcoma108
colorectal tumor26
gastrointestinal tumor50
germ cell tumor49
glioma139
head and neck tumor37
kidney tumor43
leukemia52
liver tumor41
lung tumor29
lymphoma166
non-neoplasia51
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS39
prostate cancer134
retinoblastoma150
skin tumor103
soft tissue/muscle tissue tumor71
uterine tumor99
Developmental Stage
TissuesTPM*
adult70
embryoid body157
blastocyst16
neonate32
fetus57
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue35.1
adrenal gland26.5
appendix13.9
bone marrow5.8
cerebral cortex18.1
colon19.4
duodenum17.4
esophagus24.2
gallbladder29.9
heart muscle19
kidney21.9
liver9.4
lung18.6
lymph node16.6
ovary26.7
pancreas12.7
placenta17.4
prostate21
salivary gland8.1
skin17.6
small intestine18.4
spleen18.5
stomach15.8
testis14
thyroid gland35.4
urinary bladder22.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607396, gene) Transducer of erbb2, 2; TOB2OMIM


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