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> Protein (NX_Q14126)
Protein (NX_Q14126)
Protein
Gene SymbolDSG2 to neXtProt (NX_Q14126)
DescriptionDesmoglein-2
Chromosome18
Location18q12.1 (29078006 ~ 29128971) to Ensembl
Sequene Features : Isoforms 1, Variants 170, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of ventricular cardiac muscle cell action potential
.regulation of heart rate by cardiac conduction
.bundle of His cell-Purkinje myocyte adhesion involved in cell communication
  + 9 more...
.cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
.cell adhesion molecule binding
.calcium ion binding
.extracellular exosome
.desmosome
.lateral plasma membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 170 20
2014-09-19protein level
1 135 20
2014-05-27protein level
1 135 20
2014-02-25protein level
1 134 20
2013-12-09protein level
1 99 19
2013-11-01protein level
1 98 16
2013-09-12protein level
1 98 16
2013-08-17protein level
1 98 16
2013-07-15protein level
1 71 16
2013-06-11protein level
1 71 16
2013-02-12protein level
1 40 15
2012-12-20protein level
1 36 15
2012-10-30protein level
1 48 15
2012-10-07protein level
1 48 15
2012-08-24protein level
1 44 15
2012-07-28protein level
1 44 15
2012-06-08protein level
1 48 15
2012-05-07protein level
1 38 15
2012-04-10protein level
1 38 15
2012-01-13protein level
1 27 15
2011-12-20protein level
1 27 15
2011-11-11protein level
1 27 14
2011-08-23protein level
1 26 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14126-1
51 0 0 122217.2942
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites150
bladder167
bone13
bone marrow102
brain7
cervix41
ear62
embryonic tissue201
esophagus396
eye23
heart11
intestine159
kidney147
larynx85
liver43
lung47
mammary gland165
mouth332
muscle103
nerve64
ovary19
pancreas74
parathyroid242
placenta77
prostate68
salivary gland838
skin118
stomach62
testis29
thymus50
thyroid42
trachea212
uterus51
Health State
TissuesTPM*
normal41
bladder carcinoma170
breast (mammary gland) tumor75
cervical tumor57
chondrosarcoma12
colorectal tumor222
esophageal tumor463
gastrointestinal tumor101
germ cell tumor87
glioma9
head and neck tumor194
kidney tumor217
leukemia52
liver tumor83
lung tumor38
non-neoplasia31
ovarian tumor26
pancreatic tumor47
primitive neuroectodermal tumor of the CNS7
prostate cancer115
skin tumor191
uterine tumor110
Developmental Stage
TissuesTPM*
adult82
embryoid body314
blastocyst244
fetus23
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.3
adrenal gland1.3
appendix15.5
colon101.1
duodenum70.8
esophagus10.7
gallbladder35.1
heart muscle24.3
kidney25.8
liver8.1
lung13.5
lymph node1.6
ovary13
pancreas19.1
placenta30.8
prostate29.6
salivary gland49.1
skin5
small intestine76.4
stomach66.3
testis3.8
thyroid gland39.8
urinary bladder31.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusLow
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
kidneyHigh
liverMedium
lungMedium
nasopharynxMedium
oral mucosaLow
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleMedium
skin 2Low
small intestineHigh
smooth muscleMedium
stomach 1Medium
stomach 2High
testisHigh
thyroid glandHigh
tonsilLow
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*125671, gene) Desmoglein 2; DSG2OMIM
2(#610193, phenotype) Arrhythmogenic right ventricular dysplasia, familial, 10; ARVD10OMIM
3(#612877, phenotype) Cardiomyopathy, dilated, 1bb; CMD1BBOMIM


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